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Uncertain Long Term Efficacy in Trials of Knee Osteoarthritis

d Jack Cush, MD

A systematic review and network meta-analysis of 47 randomized clinical trials in knee osteoarthritis finds uncertainty around estimates of effect size for pain scores thereby casting uncertainty over the long-term efficacy of medications for knee osteoarthritis.

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Sleep Apnea Increases Gout Risk

d Jack Cush, MD

Both Gout and obstructive sleep apnea (OSA) comingle with a wide range of serious comorbidities. A matched retrospective cohort study from the UK Clinical Practice Research database shows those with OSA are at a higher risk of developing gout.

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Severe Cutaneous Sarcoid Treated with Tofacitinib

d Jack Cush, MD

Researchers from Yale have taken a novel approach and shown benefits when using tofacitinib in severe cutaneous sarcoidosis.

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Best of 2018: The Safety of Paternal Exposure to DMARDs and Biologics

d Jack Cush, MD

Pregnancy and drug safety is a complex issue, often with limited information about maternal drug exposure on the offspring. Greater uncertainty exists when considering whether paternal exposure may also influence fetal outcomes.

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Chronic Urticaria associated with a 23% higher risk of osteoporosis, irrespective of steroid use. Population study from Israel compared 11,944 Chr urticaria w/ 59,829 controls. (HR = 1.23, 95% CI 1.10–1.37, p <0.001) https://t.co/eSq4BPV2J4

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Analysis of pegloticase clinical trial data shows that tophus resolution was achieved by 69.6% of 23 responders, 27.9% of 43 nonresponders, and 14.3% of 21 patients who received placebo. Resolution time = 9.9 mos. https://t.co/4Pu16t3BV8

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Case series compared 247 pregnancies in IgA Vasculitis patients vs 556 control pregnancies showing IgA Vasculitis had no effect on fertility and did not induce flares. But IgAV had more spont. abortions, gestational HTN, preterm delivery. https://t.co/uJirv32UYc

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“A goal without a plan is just a wish” ― Antoine de Saint-Exupéry

Dr. John Cush RheumNow ( View Tweet)

Pulmonary arterial hypertension is a very uncommon complication of Adult onset Stills disease - 4.8% of 41 AOSD pts developed PAH - often severe, with a mortality risk. https://t.co/XjyVArMNBl

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Dr. John Cush RheumNow ( View Tweet)

The Downside of social media for patients: 1. if substituted for in-person support, 2. Misinformation, 3. Financial exploitation, 4. Information overload, 5. Compromised privacy https://t.co/FtPUkZespC

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Dr. John Cush RheumNow ( View Tweet)

Social Media Benefits for patients: 1. Promotes engagement and empowerment 2. Provides psychosocial support, 3. informational support, 4. improves MD-patient relationship, 5. linical trials and cancer research education https://t.co/FtPUkZespC

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Eli Lilly has announced that FDA has granted Fast Track designation to baricitinib, to be studied for the treatment of systemic lupus erythematosus (SLE). This drug is NOT FDA approved for lupus https://t.co/vK7i6AoKab

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Dr. John Cush RheumNow ( View Tweet)

Congratulations to Professor Iain McInnes - he is one of the Queen's New Year Honours in Scotland, as a Commander of the Order of the British Empire (CBE), for his services to medicine. https://t.co/15bIELJiEj

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Dr. John Cush RheumNow ( View Tweet)

Full text review of psoriatic arthritis for NPs and PAs https://t.co/hlLKLAQ9ZX

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Abbvie has submitted its new JAK inhibitor, upadacitinib, to the FDA and EMA for consideration in moderate to severe rheumatoid arthritis https://t.co/49GspIEeYN

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Dr. John Cush RheumNow ( View Tweet)

Best wishes for a charmed 2019! My advice: 1. Just show up. 2. If you can, then you must do. 3. Live each day as if it twas your 1st day/last day/make or break day. 4. Teach

Dr. John Cush RheumNow ( View Tweet)

“Never turn down an opportunity and don’t be afraid to address your failures”. - NFL great, Michael Strathan

Dr. John Cush RheumNow ( View Tweet)

"I'm addicted to placebos. I'd give them up, but it wouldn't make any difference." - Steven Wright

Dr. John Cush RheumNow ( View Tweet)

Yet ~100 fellowship applicants did not match this year. Need creative ways to fund training programs including NP/PA. @RheumResearch has opportunities. https://t.co/acT1qew3pG

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David Karp DrDavidKarp ( View Tweet)

More than half of older Americans have "basic" or "below basic" health literacy. How do you make health care decisions when you don't even understand what the doctor is saying? https://t.co/8b3nLT6wMi

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NYT Health NYTHealth ( View Tweet)

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