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Compunded triamcinolone hexacetonide (the steroid formerly know as #Aritospan) showed significantly lower rates of joint flares compared to triamcinolone acetonide in #JIA20% vs 72%. Abstract2387 Dr. April Bingham #considercompunding #ACR18 @RheumNow https://t.co/BMBa4Z2p3t
Nicole Bitencourt NicoleBitencou5 ( View Tweet)
Secondary tumoral calcinosis in #SLE. A benign condition characterized by massive periarticular #calcification and associated with CTDs. Image by Dr. Leslie Anne Cassidy #ACR18 @RheumNow https://t.co/gs9YwwFQ3a
Nicole Bitencourt NicoleBitencou5 ( View Tweet)
#GPA with vanishing retro-orbital mass in the nasopharynx compressing eyeballs. Image by Dr. Hiroiuki Yano. #ACR18 @RheumNow https://t.co/1irkBkFvLd
Nicole Bitencourt NicoleBitencou5 ( View Tweet)
In pts with #SystemicSclerosis, cardiac MRI with T1 mapping sequence revealed microscopic #MyocardialFibrosis in 53% of pts and was associated with #cardiovascular events (7 heart rhythm disorders, 2 heart failure, 1 unstable angina) Abstract2934 Dr.Terrier #ACR18 @RheumNow
Nicole Bitencourt NicoleBitencou5 ( View Tweet)
In #SystemicSclerosis, pts with esphageal erosions on EGD had a greater decline in FVC and progression of #ILD. Emphasizes role of micro-aspiration of gastric contents in #pathogenesis of #ILD in #scleroderma. Abstract 2936 Dr. Silvia Laura Bosello #ACR18 @RheumNow https://t.co/20hOAfS6rw
Nicole Bitencourt NicoleBitencou5 ( View Tweet)
Abstract 648 OptiRef self report questionnaire for early diagnosis of a spa - 19% had confirmed diagnosis vs 40% ref from Dr. Looks useful! #AS @rheumnow #ACR18
Philip Gardiner PhilipGardiner ( View Tweet)
Abst 651 Baraliakos MRI reports on SI joints in #AS differ between radiologists and rheumatologist: edema+erosion works best @RheumNow
Philip Gardiner PhilipGardiner ( View Tweet)
Abstr 837 Dr Colmegna: Should we use high dose Infleunza vaccine in #RA? Vaccines less effective in RA DB RCT low vs. High dose in 279 RApts. Showed sig. better immune response with high dose vaccine. #ACR18 @RheumNow
Philip Gardiner PhilipGardiner ( View Tweet)
#RA #ACR18 @RheumNow
Abstr 838: Anti-MDA5 pos DM-ILD has a poor prognosis. survival at 6mo 89% vs 33% with combo imsuppressive (Pred 1mg/kg/d tapering, IVCYC 500-1g/m2; Tacrolimus through 24 wk. 29 pts, historic controls. Hi risk of CMV activation #ACR18 #Myositis @rheumnow
Philip Gardiner PhilipGardiner ( View Tweet)
Plenary Abstract 839: Dr Schmukler Chicago. Can we use MDHAQ (multi-dimensional) to identify FM? 84% agreement with 2011 FMS questionnaire - so the answer is Yes! (But what is the ‘gold std’?) @RheumNow #FMS #ACR18
Philip Gardiner PhilipGardiner ( View Tweet)
Checkpoint inhibitors
explosion of papers in 2018
New and/or exacerbated arthritis, myositis, lupus, sarcoidosis, sjogrens, vasculitis
How to treat? - still unknown
Year in review - clinical
#ACR18 @RheumNow
D White WIRheum ( View Tweet)
Risk for infection with TNFi+MTX is NOT increased compared to triple DMARD Rx confirmed in large claims database of commercial insurance #ACR18 @RheumNow abst#218 https://t.co/p25QwUX3ZN
k dao KDAO2011 ( View Tweet)
Plenary session: High dose flu vaccine is safe and has better efficacy than standard flu vaccine in our adult RA patients abst#837 @RheumNow #ACR18 https://t.co/MzAB6mUnHS
k dao KDAO2011 ( View Tweet)
Q&A 'Over half the GCA patients had LVV+ on PET/CT' [note to self: need to insist on more PET/CT and push for Tocilizumb] #ACR18 @RheumNow #GCA
Philip Gardiner PhilipGardiner ( View Tweet)
Abst 884 Jeff Sparks. Predictors of ILD in #RA in 1281 patients: High disease activity, seropositivity - no surprises #ACR18 @RheumNow
Philip Gardiner PhilipGardiner ( View Tweet)
Personal observation here: over 25 years of practice I’ve seen disease activity fall and severe ILD become uncommon - but MTX use much more common. Time to rethink! #Acr18 #RA
Philip Gardiner PhilipGardiner ( View Tweet)
Abst 2977 Dr Werth Lenabasam - cannabinoid receptor type 2 (CB2) agonist that activates resolution of innate immune responses - effective in reducing interferon beta and gamma in #Dermatomyositis skin biopsies #ACR18
Philip Gardiner PhilipGardiner ( View Tweet)
What’s in a name. Gout by any other name may be better treated. All hail Urate Crystal Arthritis#ACR18@RheumNow Abstract268 https://t.co/iGEENPJM85
William Shergy WilliamShergy ( View Tweet)
Lisa Sammaritano quoting a patient panel assisting in the development of Reproductive Guidelines for Rheumatology Patients. “My rheumatologist knows me better than my gynecologist.
William Shergy WilliamShergy ( View Tweet)
2789 Ph3 Apremilast for Behcet’s oral ulcers: significantly lower number of OU (P≤0.0015) &reduction in OU pain (P≤0.0035) vs PBO at wks 1-12. APR efficacy sustained at wk28: 62% pts achieved complete response of OU &70% relative
reduction in OU pain from BL. #acr18 @rheumnow
Olga Petryna DrPetryna ( View Tweet)