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ACR 2018 - Day 3 Report

d Jack Cush, MD

Highlights from Tuesday, day 3 of the ACR Annual meeting in Chicago, included:



The PEXIVAS Study –  2x2 Trial of Plasma Exchange and Reduced Steroids in ANCA-Associated Vasculitis (AAV) - Abstract #2788

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Axial Spondylitis Abstracts Roundup

d Philip Gardiner

There have been a number of interesting posters and presentations covering the field of axial spondyloarthropathy. I’ve picked out a few points that I found particularly relevant.



Classification Criteria

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#Plaquenil related #hyperpigmentation can occur soon after starting tx even though usually associated with long term use. By dermatologist Dr. Victoria Werth #ACR18 @RheumNow

Nicole Bitencourt NicoleBitencou5 ( View Tweet)

ACR highlights. Many Scleroderma trials were close to positive. Tocilizumab, Abatacept & Riociguat. In PsA safety and effectiveness of IL17 and also apremilast persist. Jaki safety and benefit in RA and no new signals of VTE. New SLE criteria #ACR18 @RheumNow

Janet Pope Janetbirdope ( View Tweet)

YOU need to know about checkpoint inhibitors for immune surveillance to treat melanoma and other cancers. Immune mediated adverse events presented at this mtg range from 7 ~70% depending on drug, pts, Cancer. Rx with 2 inhibitors increases risk. MSk problems 2% #ACR18 @RheumNow

Janet Pope Janetbirdope ( View Tweet)

patients underoing lung transplant for ILD in rheumatic disease have similar long-term survival rates compared to those transplanted for IPF, abstract #2974 @RheumNow #ACR18

Cassandra Calabrese CCalabreseDO ( View Tweet)

In #SystemicSclerosis, presence of higher #antivinculin antibodies (Ab against a cytoskeletal protein, also seen in IBS) was found among pts w more severe #scleroderma related GI disease. Was also assoc with scleroderma PAH/vasculopathy. Abstract 2937Dr. Suliman #ACR18 @RheumNow

Nicole Bitencourt NicoleBitencou5 ( View Tweet)

#ACR18 #2925 - Fascinating study by Xenofon Baraliakos: vertebral fatty lesions (defined by MRI) in AS biopsied at spinal surgery. Confirms that fatty lesions indeed contain fat (in contrast to degen discs). Adipocytes seem to favour osteoblast activity. @RheumNow https://t.co/m2h6tvCwQQ
ǝlʇʇıɥʍ ɯɐs samwhittle ( View Tweet)
incidence of hypogam with rituximab is low but progressively identified overtime. infection rates remain low. abstract #2971 @RheumNow #ACR18

Cassandra Calabrese CCalabreseDO ( View Tweet)

Check out Dr. Dao's coverage of the #ACR18 meeting as well as her other blogs on https://t.co/X7Lh9aCbYf. https://t.co/G7jWZ335SR

Links:

Dr. John Cush RheumNow ( View Tweet)

#IgG4 RD: bilateral lacrimal gland enlargement can occur in IgG4-RD, GPA, Sjögren syndrome. #ACR18 @RheumNow

Brittany A MissbeeMD ( View Tweet)

Subset SSc with skin DcSSc and LcSSc and antibodies to be highly predictive for organ complications. Subsets in SSc are being updated for prognosis Abst2935 #ACR18 #GameChanger @RheumNow https://t.co/ZKFDwLBs96
Janet Pope Janetbirdope ( View Tweet)
#IgG4 RD: believed that IgG4 is not the causative agent, but rather goes into affected organs in order to downregulate an immune response. #ACR18 @RheumNow

Brittany A MissbeeMD ( View Tweet)

#pseudoobstruction of the #GItract in #SystemicSclerosis was assoc with older age, diffuse skin dz, #myopathy, U3RNP, and opiod use. Abstract2939 Dr. Eric Dein. Opiod use a potentially modifiable risk factor. #ACR18 @RheumNow

Nicole Bitencourt NicoleBitencou5 ( View Tweet)

new SLE classification criteria have been validated. need to know for clinical research and (re)certification of exams. #ACR18 @RheumNow https://t.co/1ld3yrOlE1
Janet Pope Janetbirdope ( View Tweet)
Interesting to note when interpreting data @rheumnow #acr18 https://t.co/zuvBSefHC3

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k dao KDAO2011 ( View Tweet)

RheumNow expanded twitter coverage of the ACR 2018 Annual meeting sponsored in part by Horizon Pharma. All content chosen and distributed by RheumNow and its faculty.

Dr. John Cush RheumNow ( View Tweet)

J Olin: Segmental arterial mediolysis can mimic FMD. Characteristics: 1.noninflammatory, 2.nonatherosclerotic, 3.intraabdominal, 4.aneurysm/dissection 5. hemorrhagic. Dx:REQUIRES tissue examination. @rheumnow #acr18 https://t.co/kvFwRAeqRH
k dao KDAO2011 ( View Tweet)
Current MOC requirements @Rheumnow #acr18 https://t.co/NUoStoMiVO
k dao KDAO2011 ( View Tweet)
How ABAI certification differs from ABIM @rhrumnow #acr18 https://t.co/plGmDJJPSr
k dao KDAO2011 ( View Tweet)
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