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EULAR 2024 Rheumatology Roundup (6.21.2024)
Drs. Artie Kavanaugh and Jack Cush discuss highlights from the EULAR 2024 meeting in Vienna
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Update on Sjogren's disease trials
With better endpoint and patient selection strategy over the last 4 years, many new therapies have met their endpoints/shown promising signal in the Phase 2 RCTs in Sjogren's disease.
https://t.co/qMxEX73BsM https://t.co/CQWaAIO4IK
Dr. John Cush RheumNow ( View Tweet)

New Treatments for Systemic Sclerosis
aHSCT for SSc has been proven the most effective treatment strategy with regard to overall and event free survival in selected patients.2 But a key limitation is its toxicity, and new treatment options are needed.
https://t.co/xUI0plrk42 https://t.co/DqGUhU6D1Z
Dr. John Cush RheumNow ( View Tweet)

Camels and psoriatic arthritis - a new treatment link
https://t.co/0SQt3UPmKu https://t.co/zvwH9iYtxX
Dr. John Cush RheumNow ( View Tweet)

EULAR 2024 – Day 4 Report
The final day of EULAR 2024 was rich in posters, Late-breaking oral presentations and EULAR updates and recommendations. Below is a synopsis of the half-day's action.
https://t.co/1lQcu1beOm https://t.co/QHMcFzaG48
Dr. John Cush RheumNow ( View Tweet)

We've Got to Talk about CAR T cells
Dr. Yuz Yusof discusses abstract OP0017 presented at the Eular 2024 meeting in Vienna, Austria.
https://t.co/mrr5MWxeJz https://t.co/0FMLaAxaWV
Dr. John Cush RheumNow ( View Tweet)

Select your GCA Therapy
Dr. David Liew discusses LBA0001 presented at Eular 2024 in Vienna, Austria.
https://t.co/TPBeU7KaEq https://t.co/09uEzM3Kkd
Dr. John Cush RheumNow ( View Tweet)

Predicting Palindromic Prognosis
Dr. David Liew discusses abstract OP0127 at Eular 2024 in Vienna, Austria.
https://t.co/Nc0XymI24l https://t.co/69qdLh63ct
Dr. John Cush RheumNow ( View Tweet)

Giant Cell Arteritis and Polymyalgia Rheumatica Update
Dr. Janet Pope discusses abstracts LBA0001, OP0233, OP0261 and POS0280 at Eular 2024 in Vienna, Austria.
https://t.co/0V9Sle0GMU https://t.co/ixeT8L562C
Dr. John Cush RheumNow ( View Tweet)

Potential of Radiomics to Predict TNF Therapy Outcomes in axSpA
Dr. Bella Mehta interviews Dr. Vincenzo Venerito about abstract POS0236 at Eular 2024 in Vienna, Austria.
https://t.co/mv9DeZ9cez https://t.co/1OpT3MomO8
Dr. John Cush RheumNow ( View Tweet)

Update on low-dose glucocorticoids in SLE
GC have been the mainstay of treatment in SLE for nearly 75 yrs. GC induce anti-inflammatory effects, quickly relieve symptoms, and reduce mortality in life-threatening flares through various actions.
https://t.co/uEtWftvwEz https://t.co/nJlpELMj5W
Dr. John Cush RheumNow ( View Tweet)

Achieving drug-free remission in axSpA
In early axSpA, over 60% achieved sustained inactive disease. Male, non-smokers, low BASDAI scores had higher remission rates. Drug-free remission remains challenging.
https://t.co/Yv8a8C1hc9 https://t.co/JaYvfGry4P
Dr. John Cush RheumNow ( View Tweet)

POS0509 looks at time to diagnosis and #comorbidity burden in #axSpa
Retrospective study in French THIN database
Diagnostic delay remains common
Increased number of MSK & non-MSK manifestations & #comorbidities over time vs 1st presentation of back pain
#EULAR2024 @DrMiniDey https://t.co/egwDL1XjSw
Dr. John Cush RheumNow ( View Tweet)

#EULAR2024 LBA0009 Phase 3 Open label H2H RCT of Ixekizumab vs in jPsA & enthesitis-related arthritis showed similar ACR30 response rates at Wk16 (IXE=89%; ADA=95%). Open label and long-term follow up for IXE is ongoing to assess for sustainment @Yuz6Yusof https://t.co/eSqOkBGBK2
Dr. John Cush RheumNow ( View Tweet)

Proportion of ILD patients on IS drugs has massively increased over time!
Also good to see practices are changing & MTX is slowly creeping in
Anna Maria Hoffmann-Vold, ILD management session #EULAR2024 @AurelieRheumo https://t.co/npa8O7g7l8
Dr. John Cush RheumNow ( View Tweet)

PMR has distinct patterns on MRI shoulder, possibly helping Dx.
#EULAR2024 OP0248 @drdavidliew
also
@bmj_rmdopen
https://t.co/0J3xUmb9yt where they say:
"Similar to our prior findings... the target of inflammation in PMR is the outer covering of a tendon, the peritendineum" https://t.co/AzWkg3z2vR
Dr. John Cush RheumNow ( View Tweet)

How good are we at picking up depression in RA patients?
In this Polish registry:
- 1.8% had depression diagnosis
- 21% had low mood on HAQ
& depression has real correlates with disease activity.
Plenty to think about with truly holistic RA care!
#EULAR2024 POS1045 @drdavidliew https://t.co/ArfqHCKxhz
Dr. John Cush RheumNow ( View Tweet)

Choices in GCA
https://t.co/e994wGiUwb https://t.co/psr9NV0OA6
Links:
Dr. John Cush RheumNow ( View Tweet)

Difficult-to-treat RA: are we any closer to predicting who is at risk?
4 years ago EULAR published its definition of D2T RA. This marked a formal recognition of patients who, despite the advances in pharmacological therapy for RA, remain symptomatic.
https://t.co/kQJeUiRNtY https://t.co/xJEVihBMfm
Dr. John Cush RheumNow ( View Tweet)

EULAR 2024 – Day 3 Report
We are sharing a few of our favorite abstracts and presentations from today, day 3 in Vienna.
https://t.co/XgceAQFVQC https://t.co/80jrjv6Awn
Dr. John Cush RheumNow ( View Tweet)