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Pre-Treatment Testing with Biologics Falls Short

Jack Cush, MD Feb 01, 2024

US commercial insurance claim analysis of laboratory screening and monitoring practices in chronic inflammatory skin disease (CISD) patients shows that < 60% received the recommended pretreatment testing when starting systemic immunomodulatory treatment.

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Half of Subclinical Synovitis Patients May Remit

Jack Cush, MD Jan 30, 2024

Ultrasound subclinical synovitis is found in a third of individuals at risk of rheumatoid arthritis (RA) patients; in half of these, subclinical synovitis resolves with a favorable outcome.

240 consecutive estab. RA pts underwent cervical spine X-rays looking for ant. atlantoaxial subluxation (aAAS >3 mm); aAAS found in 25 (10.4%) mean interval =4.2mm. One-third had no neck pain. aAAS predicted by lower BMI, CCP, erosions & joint prostheses https://t.co/VTMdv6wudB https://t.co/RDbjjuJAjD

Prevalence of anterior atlantoaxial subluxation and association with establishe…

Greek study finds 251/1264 #RA pts (20%) had difficult to treat RA (D2T). D2T Predictors were Younger age, fibromyalgia, OA, no change in DAS28-ESR in 1st 6mos b/ts-DMARD Rx. Mental-/pain-/metabolic-Dz contributed to LT worsening https://t.co/A5bfth79L2 https://t.co/f5AOvFW9Yu

Patterns of comorbidities differentially affect long-term functional evolution …

Metabolic Syndrome increases RA risk. UK Biobank (369,065) study saw 4901 incident RA (12 yrs F/U). Signif hi RA risk with MetS (HR 1.22), waist circumf (1.21), incr TG (1.12), decr HDL (1.31) & hyperglycemia (1.15) - all additive. https://t.co/jN15axxTmu https://t.co/DP5bFwOB3F

Metabolic Syndrome Is Associated With an Increased Risk of Rheumatoid Arthritis…

Study of 235 newly Dx #RA patients (157 females) found that 11 pts (5%) had carpal tunnel syndrom (CTS) at the time of initial RA diagnosis. Such pts were more likey to be older, female, CCP negative and have a longer Sx duration. https://t.co/Jb3hynyqGx https://t.co/EbTvHGq5Yk

Characteristics of patients presenting with concomitant carpal tunnel syndrome …

Prevalence of Cardiovascular Disease in Rheumatoid Arthritis A prospective study of the BioSTAR registry estimates the prevalence of cardiovascular disease in rheumatoid arthritis (RA) to be 4.6%. https://t.co/NRn0DrYoBX https://t.co/qOoTmBNB1p

Prevalence of Cardiovascular Disease in Rheumatoid Arthritis | RheumNow

Clinical implications of immune aging. Connie Weyand. #RNL2024 @RheumNow https://t.co/QUbvkIvPco

https://twitter.com/NoufAhmedAlham2/status/1751282766853861858/photo/1

Stressed ER is a major TNF producer. Connie Weyand. #RNL2024 @RheumNow https://t.co/zsSD8XWFcP

https://twitter.com/NoufAhmedAlham2/status/1751282703146594465/photo/1

Consequence of aged immune system. Connie Weyand. #RNL2024 @RheumNow https://t.co/gfCTfzulR9

https://twitter.com/NoufAhmedAlham2/status/1751282644325630160/photo/1

Inflammation or Inflammaging? The aging immune system in the host predisposes the development of RA, Cornelia Weyand, #RNL2024 @RheumNow https://t.co/30Zbf8kRXs

Aging in RA: "(RA) is due to a poorly functioning immune system which increases a patients risk of CVD, infection, and cancer. The aging immune system additionally affects this process. We must consider this clinically, we must protect our aging patients without over… https://t.co/TlHyTxPMNc https://t.co/JBVg4uqn6A

#RNL2024 @RheumNow As we age, we gain not just wisdom, but also "Inflammaging" Immune system changes in our inflammatory cells lead to: - Poor vaccine response - High risks for infections - High risk for CVD - High risk for autoimmunity https://t.co/golMAPR0ZI

https://twitter.com/ericdeinmd/status/1751268127428542549/photo/1

Useful resource on dietary guidance in RA from @ACRheum focusing on a MD-like diet #RNL2024 @RheumNow https://t.co/QplaQ1caxv.

2022 American College of Rheumatology (ACR) Guideline for Exercise, Rehabilitat…

Vit d and omega 3 reduces incidence of RA. Hani El Gabalawy. #RNL2024 @RheumNow https://t.co/BGGbLvMhhT

https://twitter.com/NoufAhmedAlham2/status/1751262695154663763/photo/1

Good number of ACPA positive patients reverts to ACPA negative in 5 years. Hani El Gabalawy. #RNL2024 @RheumNow https://t.co/yLxO0ulsam

https://twitter.com/NoufAhmedAlham2/status/1751262639466963411/photo/1

Dr. Kavanaugh: "Role of alcohol on inflammation? It's part of the Mediterranean diet!" Dr. Guma:"The data is mixed; polyphenols may be beneficial; alcohol in limited quantities was allowed in studies" Dr. Weber:" Be careful w/EtOH in pts w/palpitations" #RNL2024 @rheumnow

Do you use the ASA24? Dr. Gabalawy asked Dr. Guma about this index at the #RNL2024. These indices don't quite encompass all aspects of the ACR recommended Mediterranean diet, for example, but could be useful in developing better assessments for patients and their diet.… https://t.co/v4Fu43u7et https://t.co/CTV2IaJ1xW

Panel discussion online and in person on #rheumatoidarthritis #RNL2024 Dr. Weber discusses with Dr. Guma, Dr. Gabalawy and @rheumnow ways to assess CV risk in patients by looking at family history, inflammation, comorbidities, imaging studies https://t.co/yM58kvr7CR

https://twitter.com/KDAO2011/status/1751259864498614376/photo/1

How do you communicate risk/benefit to patients? @RADoctor's recent publication highlighted by Dr. H. Gabalawy at #RNL2024 @RheumNow 1. Increase awareness 2. Include numbers for context 3. Make it easy for patients to understand those numbers 4. Use absolute risks 5. Avoid 1 in… https://t.co/DqmgD2j5Wp https://t.co/v6CQAX9YRr

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Pre-Treatment Testing with Biologics Falls Short

Half of Subclinical Synovitis Patients May Remit

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