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High- Versus Low-Dose Exercise Therapy for Knee Osteoarthritis The Annals of Internal medicine has reported the results of high-dose versus low-dose exercise therapy demonstrating no benefits from more intense exercise. https://t.co/BtqeYWKG34 https://t.co/ngyM1DshDz

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Dr. John Cush RheumNow ( View Tweet)
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High- Versus Low-Dose Exercise Therapy for Knee Osteoarthritis

d Jack Cush, MD

Exercise is known to improve function, pain and quality of life (QOL) in patients with knee osteoarthritis (KOA), but optimal amount of exercise is unknown.

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Novel Proteomic Biomarker Set in Osteoarthritis NIH funded researchers have developed a set of serum proteomic biomarkers that successfully predict clinically relevant KOA progression (both structural change and joint pain) over a 2 year period. https://t.co/4xU2bYS0xN https://t.co/Rtdr280ghe

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Dr. John Cush RheumNow ( View Tweet)
labs2.jpg

Novel Proteomic Biomarker Set in Osteoarthritis

d Jack Cush, MD

NIH funded researchers from Duke University have developed a set of serum proteomic biomarkers that successfully predict clinically relevant knee osteoarthritis (KOA) progression (both structural change and joint pain) over a 2 year period.

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Deptof Veterans Affairs has awarded $1.2 million to Matlock Jeffries, MD of the Oklahoma Medical Research Foundation to study the connection between obesity, gut microbiome and cartilage changes leading to osteoarthritis of the knee. CONGRATS @matlockj https://t.co/M3807QD5K2 https://t.co/ypJNunbWWS

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Dr. John Cush RheumNow ( View Tweet)
Blood Test Identifies Osteoarthritis Progression A new blood test that can identify progression of osteoarthritis in the knee is more accurate than current methods, providing an important tool to advance research and speed discovery of new therapies. https://t.co/hOAjxJhnJG https://t.co/Ehr5imPNQ4

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Dr. John Cush RheumNow ( View Tweet)
OA,biomarker

Blood Test Identifies Osteoarthritis Progression

d EurekAlert!

A new blood test that can identify progression of osteoarthritis in the knee is more accurate than current methods, providing an important tool to advance research and speed discovery of new therapies.

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Scale,weight

Burden of BMI on Costs of Musculoskeletal Diseases

d Jack Cush, MD

A cross-sectional global study shows a substantial impact of obesity and BMI on the health and economic impact of patients with musculoskeletal (MSK) disorders.

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New Hope for Hand Osteoarthritis The drug talarozole – which increases retinoic acid – could be a promising new treatment for hand osteoarthritis. https://t.co/AHoEZM75mh https://t.co/dZ1LWWoNl5

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Dr. John Cush RheumNow ( View Tweet)
Degeneration seen in #OA may be related to cartilage tissue stiffening with the repression of a key longevity protein α-Klotho brought about by epigenetic changes. Downregulated Klotho gene expression accelerated chondrocyte senescence https://t.co/HBLeLIlmJG https://t.co/T7d6EodDYN

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Dr. John Cush RheumNow ( View Tweet)
Network meta-analysis of 152 RCTs (17431 pts) comparing efficacy of exercise therapy, NSAIDs, Tylenol for knee or hip osteoarthritis: Found all 3 equivalent at 4 wk, 8 wk and 24 wks. https://t.co/rKck2AacL4 https://t.co/YEAMh9UxTs

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Dr. John Cush RheumNow ( View Tweet)
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Cannabis Use for Pain is Common

d Jack Cush, MD

In states with legalized medical cannabis use, 3 in 10 persons are using cannabis to manage their pain.

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sit,sedentary,couch,coffee,comfort

Extreme Global Costs of Physical Inactivity

d Jack Cush, MD

A global, population-based study shows that physical inactivity is not only an important modifiable risk factor for non-communicable diseases (NCDs) and mental health conditions, it also imparts a considerable health and economic burden that is avoidable.

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Hyaluronic Acid Knee Injections Equivalent to Placebo In the United States, where over $300 million is spent annually on intraarticular hyaluronic acid injections, yet another study shows such therapy to be no better than placebo. https://t.co/bBEwpId84L https://t.co/5msGqViTpz

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Dr. John Cush RheumNow ( View Tweet)
Effect of Intraarticular Steroid Shots on Knee OA Outcomes In patients with osteoarthritis of the knee, intra-articular injections of steroids did not increase rates of either disease progression or subsequent knee replacement surgery, researchers said. https://t.co/yqVHPmqzzi https://t.co/k8dMADHg7P

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Dr. John Cush RheumNow ( View Tweet)
New Hope for Hand Osteoarthritis The drug talarozole – which increases retinoic acid – could be a promising new treatment for hand osteoarthritis. https://t.co/jVMLiJLnch https://t.co/0nk8WA2k1S

Links:

Dr. John Cush RheumNow ( View Tweet)
OA.DIPs_.PIPs_.jpg

New Hope for Hand Osteoarthritis

d EurekAlert!

The drug talarozole – which increases retinoic acid – could be a promising new treatment for hand osteoarthritis.

Read Article
knee.surg2_.jpg (keep)

Metformin Reduces Osteoarthritis Risk in NIDDM Patients

d EurekAlert!

Osteoarthritis is a common chronic condition that usually causes joint pain and can be severe enough to require knee and hip replacements.

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Marginal Benefit with Diet and Exercise in Obese Knee Osteoarthritis Patients The easiest intervention for knee osteoarthritis (diet and exercise) is also the most difficult for many patients; but do these work? https://t.co/s4Gzmh2gGZ https://t.co/aZORTMtCvs

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Dr. John Cush RheumNow ( View Tweet)
#OA phenotypes by SF cell status - Activated: hi T-cell, low mono–macrop-PMN activated; 70% improved - Lymphoid: hi PMN, low lymph & mono, low activ, lower pain - Myeloid: hi NK & mono, low T-cell & activat - Aggressive: hi lymph/macr/NK/PMN;39%improve -https://t.co/3DXPoDE5Pm https://t.co/VRJkscAm5a

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Dr. John Cush RheumNow ( View Tweet)

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