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IgG4: Rare, but new treatments on the horizon

Janet Pope, MD, MPH, FRCPC

IgG4 is a rare autoimmune disease with excessive IgG4 immunoglobulins that can affect multiple organs yielding plasma cell deposition (inflammation) and fibrosis.

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ACR 2025 - Day 3 Report

Jack Cush, MD

Day 3 in Chicago is hump day, the last big full day of presentations and posters.  The day began with an 8AM plenary session, which brings me to the first of my three notables from today:

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The Great Debate – Who Really Won?

Michael Putman, MD, MSCI

My favorite session at ACR Convergence is often the “Great Debate.” The debate this year also evaluated one of my favorite topics – ultrasound in giant cell arteritis (GCA). More specifically, it asked the question of whether biopsy or ultrasound should be the preferred modality for diagnosing GCA.

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Accelerated Aging in Rheumatic Disease: From Biology to Lifestyle Intervention

Jiha Lee, MD

At ACR 2025, the session “27M02: Nutrition for Rheumatic Disease: Where Aging Biology, Sarcopenia, and Diet Intersect” invited the audience to view rheumatic disease through the lens of biological aging and to consider how nutrition and exercise can serve as integrative lifestyle interventions.

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RheumNow’s expanded coverage of the #ACR25 annual meeting is sponsored by Bristol Myers Squibb, Novartis, and UCB. All coverage content is independently selected by RheumNow and its faculty.

Dr. John Cush RheumNow ( View Tweet)

Day 3 Recap- ACR Convergence 2025 Highlights https://t.co/4ZiTWVVwhl The analogy used by @RheumNow to explain difference between completion versus intention to treat analysis hahahaha. You look good either ways! @bella_mehta @RHEUMarampa @EBRheum

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Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)

#ACR25 Abstr#LB15 Tell #RA patients on methotrexate that eating high fibre diet is good for them! An RCT showed improved EULAR response vs PBO. Likely due to restoration of Th17/Treg balance @RheumNow https://t.co/NbwQFqJNho

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Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
#ACR25 Abstr#2411 How good is performance of 2019 ACR-EULAR #SLE criteria at the point of diagnosis in At-Risk ANA+ people? Our group compared this with Clinician dx -> high specificity(93.8%); low sensitivity(79.3%). Might be a cause why SMILE HCQ RCT failed in At-Risk @RheumNow https://t.co/6GNU2B2wvj

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Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Can we catch PsA before it starts? My take on #ABSTRACT0877 for #ACR25 @RheumNow https://t.co/Rw2gJ4XSsz

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Aurelie Najm AurelieRheumo ( View Tweet)

What a conference! Thanks to all those who stopped by! #ACR25 https://t.co/UMAqnPdK4t
Dr. John Cush RheumNow ( View Tweet)
Lung Disease in ANCA-associated Vasculitis Dr. Mike Putman discusses abstract 0721, "Pulmonary Manifestations of Granulomatosis with Polyangiitis and Microscopic Polyangiitis", presented at #ACR25. https://t.co/A5uKT4jG1I https://t.co/7E4k7QdiNK

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Dr. John Cush RheumNow ( View Tweet)
ACR2025 Day 3 Recap https://t.co/ZQ1mZePZ1S

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Dr. John Cush RheumNow ( View Tweet)

In healthy women, preeclampsia was more common with: - increased calprotectin - decreased anti-CCP (very low levels) during pregnancy & this has good predictive capacity for future preeclampsia. Rheum pathophys can give insights into adjacent pathology #ACR25 ABST2628 @RheumNow https://t.co/7d5YB6n6XJ

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David Liew drdavidliew ( View Tweet)
#ACRBest @RheumNow https://t.co/SP3tib5tL1

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Aurelie Najm AurelieRheumo ( View Tweet)

What's new in sjogren's? Promising phase III data of telitacicept (dual BLyS + APRIL neutralization) Pt in both dosing groups with decrease in ESSDAI compared to PBO but best results at higher (160mg) dose Similar rates of adverse events @RheumNow #ACR25 Abst LB11 https://t.co/r9JaVKzedH

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Brian Jaros, MD Dr_Brian_MD ( View Tweet)
RheumNow’s expanded coverage of the #ACR25 annual meeting is sponsored by Bristol Myers Squibb, Novartis, and UCB. All coverage content is selected by RheumNow and its faculty.

Dr. John Cush RheumNow ( View Tweet)

Is AI Smarter than a Doctor? Dr. Janet Pope reviews key takeaways from the session, "Artificial Intelligence in Medical Education: From Theory to Practice," at #ACR25. https://t.co/F6KEYAWi75 https://t.co/m57asdLGrn

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Dr. John Cush RheumNow ( View Tweet)
Making sense of machine learning. Key slides on Discriminative AI vs Generative AI. Liubov Arbeeva @RheumNow #ACR25 https://t.co/Xli1mSTVQf

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Antoni Chan MD (Prof) synovialjoints ( View Tweet)
Perhaps it was my ignorance, but a FDA-approved therapy for fibromyalgia was not on my 2025 bingo card. We’re not exactly overwhelmed with proven options for FM, the unmet need is so great, so the more, the better. #ACR25 FDA session @RheumNow https://t.co/wwWijl3IyW

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David Liew drdavidliew ( View Tweet)
@US_FDA rheumatology approvals, 2025 #ACR25 @RheumNow https://t.co/uVLWqBx45m

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David Liew drdavidliew ( View Tweet)
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