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Extension PEXIVAS study in ANCA vasculitis pts with severe DAH - no significant effect of PLEX on mortality but do note numerical difference, favoring PLEX in severe DAH - note difference in curve @RheumNow #RNL2023 https://t.co/6ktb3Uakw9

Biosimilar to biosimilar switching of Infliximab , ⁦@RheumNow⁩ Kavanaugh #RNL2023 Communications is a key always. Discuss with your patient always, and show them the data. https://t.co/d7Nq6LoJYQ

How does HCQ work @Lupusreference in #RNL2023 HCQ works by inhibition of Toll-like receptor (TLR) with affects on IFN HCQ works as base to increase lysosomal pH and affect cellular function @RheumNow https://t.co/RTEUF0cS0u

Smoking and SLE Smoking increases SLE activity Smoking decreases HCQ efficacy Skin response on HCQ down 50% in smokers 🚬 @Lupusreference #RNL2023 @RheumNow

✅ Check my TAKE-HOME MESSAGES about #hydroxychloroquine & #Lupus for RheumNow Live 2023 #RNL2023 @RheumNow ⬇️ https://t.co/E2xdv3ODG6

SRI Responders more likely able to reduce prednisone and far Serological improvement SF-36 Fatigue by Richard Furie #RNL2023 ⁦@RheumNow⁩ https://t.co/ilsyOXw7nA

#RNL2023 Year in Review COMPLETE-PsA: DMARDs for PsA! LEF+MTX better than MTX alone, 78 total patients PASDAS at week 16: 59% for MTX+LEF vs 34% MTX+PBO More treatment discontinuations (10 vs 3) in combo group due to GI intolerance @RheumNow https://t.co/3Al8PQmNli

Should we be measuring HCQ levels? - note HCQ doses should be reconsidered in pts with CKD stage >2 w/ 4 fold higher odds of HCQ levels - adjust dose for pts with renal impairment @RheumNow #RNL2023 https://t.co/JvaRJKJRPv

#RNL2023 Year in Review BE COMPLETE: P3 trial Bimekizumab for PsA in TNF inadequate responses at 16 weeks 160 mg BKZ SQ q4w vs PBO ACR50 43%, PBO 7% PASI 1000: BKZ 58.5% vs PBO 4.5% Safety: oral candidiasis: 2.6% BKZ vs PBO 0% @RheumNow https://t.co/bW00Wg6Cnf

Talk to me about candidiasis. BKZ showed increased safety signals for candida infections. I fear infxns may be under reported (after approval and in use) if patients see other physicians for treatment vs their rheumatologist/derm. Thoughts on this signal? #RNL2023 @rheumnow https://t.co/UPA5oP9G49

Could MTX every other week dosing be an option in patients with stable disease..? #RNL2023 https://t.co/EZRdQnuXjy

Year in Review by Dr. Cush and Dr. Kavanaugh Combo biologic therapy? Phase II study from GI colleagues for UC Guselkumab + golimumab - no additional safety concerns - improved clinical response - extrapolate to rheumatology use? #RNL2023 @RheumNow https://t.co/DirAovm1AX

✅ RheumNow Live 2023 #RNL2023 @RheumNow Which adverse events ⬇️ can be expected by patients & their rheumatologists when using #hydroxychloroquine for #Lupus? https://t.co/9zP8aJ4cGq

#ClinicalPearl #Methotrexate weekly May reduce side effects in rapidly dividing cells vs using it daily or every few days. GI, oral, bone marrow side effects should be less if once a week. Joel Kremer ⁦@RheumNow⁩ #RNL2023 https://t.co/i0LZoQuK0w

Do you stop MTX on patients on bDMARD? MTX decrease anti-drug antibodies on patients on infliximab - increases drug duration. Similar seen with new combination usage with pelogloticase Joel Kremer MD #RhuemNow @RheumNow https://t.co/8UrGZaFStA

How do you wean MTX? Consider every other week dosing as options - supported by 2 randomized studies from 1995 and 1999 Option to lower weekly dosing in patients that want to take less often Joel Kremer #RNL2023 @RheumNow https://t.co/3GMdn3lLhy

Do and don’t around MTX , Dr.Kremer approach to MTX #RNL2023 ⁦@RheumNow⁩ https://t.co/dXLQ0epsp4

Jaks are every where in Psoriatic disease domains, By Eric Ruderman #RNL2023 ⁦@RheumNow⁩ Good news, especially with Updacitinib recently and Crohn’s disease ( full package). https://t.co/nlBWJhzpLp

DMARDs/TNF for PMR: MTX- initial benefit, but no 5 year steroid sparing effect Infliximab - no benefit Lef - some benefit in case series Robert Spiera #RNL2023 @RheumNow https://t.co/cmwGEWHQEO

JAKinib safety takeaways - avoid in older population > 65 yo, malignancy, CV risk, VTE risk - appropriate in younger pts without VTE/CVD risk factors #RNL2023 @RheumNow https://t.co/5i1bRqqr7g

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