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Activity & Pain Tolerance (3.29.2024)
Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com, including where you should sit in clinic and why you should worry about secondary Sjogren's in RA.
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7 Updates on Prosthetic Joint Infections
These are excerpts and takeaway summaries from several literature reports addressing the diagnosis and outcomes of prosthetic joint infections (PJI).
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Systemic Score Predicts Still's Disease Severe Complications
A multinational study of adults with Still's disease found that calculating their systemic score at baseline significantly predicted the patients risk for life-threatening outcomes (MAS or death).
Higher Rates of Childlessness in Rheumatic Diseases
A large Finnish population study shows that several rheumatic diseases may impair reproduction and pregnancy outcomes, with significantly higher rates of childlessness or fewer children overall for women.
ACR Supports FY 2024 Budget
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ACR
The American College of Rheumatology (ACR) today expressed strong support for several key measures included in the Fiscal Year (FY) 2024 budget.
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Higher Rates of Childlessness in Rheumatic Diseases
A Finnish population study shows that several rheumatic diseases may impair reproduction and pregnancy outcomes, with significantly higher rates of childlessness or fewer children overall for women.
https://t.co/pBoSBGGMxA https://t.co/j8RGT9qrKL
Dr. John Cush RheumNow ( View Tweet)
ACR Supports FY 2024 Budget
The ACR expressed strong support for several key measures included in the Fiscal Year (FY) 2024 budget.
https://t.co/rviB0yKxOd https://t.co/LY8AzsgWjX
Dr. John Cush RheumNow ( View Tweet)
September 2023, CDC’s recommended the updated 2023–2024 booster COVID Vaccine (monovalent XBB.1.5). MMWR study shows only 18% of high risk (immunocompromised) recv'd it. Vax was 38% effective at preventing COVID hospitalization https://t.co/vf5jkMkPwj https://t.co/c55SuIuaDb
Dr. John Cush RheumNow ( View Tweet)
GEM: Dysphagia in myositis pts is from skeletal muscle involvement, causing upper pharyngeal dysphagia, but may also manifest as dysphonia, nasal regurgitation, or aspiration (w/ risk of pneumonia). https://t.co/7UMHcX7suO
Dr. John Cush RheumNow ( View Tweet)
>25% of elderly fall each yr; falls are leading cause of injury-related death in > 65 yrs. PT & Functional exercises to improve leg strength and balance are recommended for fall prevention in @risk populations & show 20-30% less risk overall https://t.co/IPQoS4dUpS https://t.co/qUEwLX0KEq
Dr. John Cush RheumNow ( View Tweet)
57 yoBM advertising executive (w/ comorbidities) has
insidious & progressive myalgias and weakness - arms and legs; most likely Dx?
Dr. John Cush RheumNow ( View Tweet)
Wrist pain differential diagnoses beautifully demonstrated 👍 Remamber that radial-sided wrist pain is more common that ulnar-sided wrist pain. https://t.co/3Ite2FsYtl
Dr. OMID BANDARCHI OBandarchi ( View Tweet)
Predicting Vasculitis Relapse
Scores on a patient-reported sino-nasal symptom questionnaire were associated with subsequent flares of one type of ANCA-associated vasculitis (AAV), researchers said.
https://t.co/2IjrXiGbIA https://t.co/4uTsa6mc77
Dr. John Cush RheumNow ( View Tweet)
Chikungunya Arthritis - 2 studies show benefit of dexamethosone (up to 4mg/d) w/ improved DAS28 scores; Uncertain benefit however with MTX; 133 Brazilian pts studied for 5 mos & 31 pts studied for 8wks. https://t.co/Ko3aRYX0xi https://t.co/rtC4RCRjnU https://t.co/XOoFYw0dR4
Links:
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Long term outcomes of phase III KEEPsAKE 2 trial in #PsA; SC risankizumab 150 mg given q12wks (after wk 24). 78% were ongoing. RZK achieved 60% ACR20 at wk 52, 57% ACR20 at wk 100, & 75% maintained ACR20 to wk 100. MDA achieved in 34% & 33%.https://t.co/juYQklrhG3 https://t.co/8uhmydPZDf
Dr. John Cush RheumNow ( View Tweet)
Cabaletta Bio announced FDA has granted Orphan Drug Designation to CABA-201, a 4-1BB-containing human CD19-CAR T cell agent, to treat systemic sclerosis. RESET (REstoring SElf-Tolerance) trial program includes the Phase 1/2 RESET-SSc trial https://t.co/SWAwLs4PzG https://t.co/3yJ8zlhN9C
Dr. John Cush RheumNow ( View Tweet)
Norwegian Institute of Public Health found that among more than 10,000 adults, those who were physically active had a higher pain tolerance than those who were sedentary; and the higher the activity level, the higher the pain tolerance. https://t.co/yH6kckcBTA https://t.co/BlCXV0VjP2
Dr. John Cush RheumNow ( View Tweet)
Korean biologics registry study 526 Ank Spondylitis pts on TNFi > 1yr and tapered; 24.1% experienced flares. Predictors of flare included B27+, inflammatory LBP, psoriasis, SpA Fam Hx, DM, ≥50% TNFi tapering, Dz activity (ASDAS-CRP, BASFI) at tapering https://t.co/Pila2PBlpN https://t.co/WgF9UtfTiR
Dr. John Cush RheumNow ( View Tweet)
GEM: Your Clinic Desk needs to be where you can see your patients enter/walk/rise into the clinic. Also pts can see where you work. They learn you & you learn them in ways not gleaned from the exam room https://t.co/WfFqiuztW1
Dr. John Cush RheumNow ( View Tweet)
Window of Opportunity in Psoriatic Arthritis
A Dutch Early Psoriatic Arthritis cohort study shows that psoriatic arthritis (PsA) patients treated early (referred and diagnosed within in less than 12 weeks) had the best clinical outcomes.
https://t.co/mbftcq1dv8 https://t.co/VYNtByK9l0
Dr. John Cush RheumNow ( View Tweet)