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Predicting Vasculitis Relapse
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MedPage Today
Scores on a patient-reported sino-nasal symptom questionnaire were associated with subsequent flares of one type of ANCA-associated vasculitis (AAV), researchers said.
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Window of Opportunity in Psoriatic Arthritis
A Dutch Early Psoriatic Arthritis cohort study shows that psoriatic arthritis (PsA) patients treated early (referred and diagnosed within in less than 12 weeks) had the best clinical outcomes.
Secondary Sjogren’s Ups Rheumatoid Arthritis Severity
A Swiss observational study has shown that rheumatoid arthritis (RA) patients with concomitant Sjögren’s disease (SjD) are more likely to have a severe RA phenotype, and be less responsive to treatment.
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Secondary Sjogren’s Ups Rheumatoid Arthritis Severity
A Swiss observational study has shown that RA patients with concomitant Sjögren’s disease (SjD) are more likely to have a severe RA phenotype, and be less responsive to treatment.
https://t.co/CZqLO2GSeM https://t.co/VyLKvUIfJ9
Dr. John Cush RheumNow ( View Tweet)
Obesiy (& Visceral abdominal fat) in Ankylosing Spondylitis is assoc w/ worse Dz activity, funct disability, & spinal mobility in study of 74 radiographic axSpA treated with bDMARDs. https://t.co/Z5e9cU62nS https://t.co/fD9lhj085B
Dr. John Cush RheumNow ( View Tweet)
High Mortality & complication rates seen in 53 #RA pts presenting w/ Periprosthetic joint infection - 54 PJI w/ avg age 65 yrs (32-88); mortality rate was 19%. Most common was Staphylococci (63%), w/ 20% w/ multiorganism infx & 6 C/S neg https://t.co/Syrm5qPKDQ https://t.co/bnMfMLmFJ7
Dr. John Cush RheumNow ( View Tweet)
BIOBADASER registry 1128 RA pts Rx w/ 1st ts/bDMARD, Among the 9.3% w. multimorbidity they noted higher DAS28 dz activity, but no differences in ts/bDMARD retention rates betw those w/ and without multimorbidity https://t.co/hZDpceuOFq https://t.co/pxSg6rKNNr
Dr. John Cush RheumNow ( View Tweet)
Korean claims study of #RA & pregnancy (& adverse preg outcomes (APO), shows MTX or LEF use w/in 3 mos of conception assoc w/ incr. in APOs (aOR 2.14-.68). In 5728 preg: 1152 APOs, HCQ most commonly used, DMARD use decreased during preg. https://t.co/fGRZS5ID4A https://t.co/LXaaVYcFsh
Dr. John Cush RheumNow ( View Tweet)
Post-COVID MDs spend more time on EHR mostly messaging w/ patients, with a 157% increase from prepandemic average. Each additional patient message was associated with a 2.32-min increase in EHR time per day (P < .001), mostly messaging https://t.co/yfPM3vTmRo https://t.co/XVwC50CH2C
Dr. John Cush RheumNow ( View Tweet)
Naysayers & Disrupters
Dr. Jack Cush reviews the news and journal reports from the past week - including a few contrary reports on infection, seropositivity and plasmapheresis.
https://t.co/tm3V8U7pv4 https://t.co/R8U04urRXg
Dr. John Cush RheumNow ( View Tweet)
Autoimmune dz pts have higher risk of macular degeneration. Cleveland Clinic study of 200K AMD vs controls, finds:
- SLE (RR 1.73)
- Scleroderma (1.65)
- Psoriasis (1.48)
- Vasculitis (1.48)
- RA (1.4)
- UC &CD (~1.42)
- Sarcoid (1.42) https://t.co/RKyriK1zPe https://t.co/9F7N1jHKxX
Dr. John Cush RheumNow ( View Tweet)
According to CDC, drug overdose deaths increased in 2022 - up to 107,941, ~1% higher than the nearly 107,000 overdose deaths in 2021. 70% of these are males. 2023 numbers are not yet final but appear to be stable... https://t.co/esTuwpp4YP https://t.co/Ap5XanllU9
Dr. John Cush RheumNow ( View Tweet)
CV Risk Early with Rheumatic Disease Diagnosis
A Finnish populaton study shows that the temporal relationship between cardiovascular (CV) comorbidities in rheumatic diseases (RMD) is seen early after the RMD diagnosis.
https://t.co/GlcVJdx7Ls https://t.co/VKp6Tgqkof
Dr. John Cush RheumNow ( View Tweet)
2023 EULAR Psoriatic Arthritis Recommendations
EULAR has updated its treatment recommendations— The updated guidance includes 7 overarching principles and 11 recommendations regarding treatment strategy and pharmacological therapies.
https://t.co/0hofxzGX9O https://t.co/FXOgEJ0P0F
Dr. John Cush RheumNow ( View Tweet)
Case of Delayed Rheum Diagnosis
The Washington Post recently published a case titled, "Medical Mysteries: A rolled ankle set this runner down a painful path", which tells the tale of how/why rheums are often not consulted or consulted too late.
https://t.co/Iigmf5jdDu https://t.co/mYYm5CEvtX
Dr. John Cush RheumNow ( View Tweet)
Research on SGLT2 inhibitors in #gout is needed. They have been shown to reduce uric acid & gout flares, and may be uricosuric or be antiinflammatory. Also decreased incident gout (by half) among at-risk patients with type 2 diabetes (HR 0.54) https://t.co/ZEmhwqyDOv https://t.co/58YKD6pFyt
Dr. John Cush RheumNow ( View Tweet)
Marketing research suggests that the global rheumatoid arthritis drug market was valued at USD $17.87 billion in 2023 and is projected to reach around USD 25.67 billion by 2032 https://t.co/w4ErmjtFNV https://t.co/5bmcVJ7zh4
Dr. John Cush RheumNow ( View Tweet)
Marketing research estimates there were 1,389,116 prevalent cases of Ankylosing Spondylitis in 2017 https://t.co/bn4QHBNxEd https://t.co/BN1aNvgebS
Dr. John Cush RheumNow ( View Tweet)
Chronic MSK Pain and Earlier Retirement
Frequent musculoskeletal pain is linked with an increased risk of exiting work and retiring earlier, according to a new study published in the journal PLOS ONE.
https://t.co/wRKYjmtaAX https://t.co/n5HzbDNmGz
Dr. John Cush RheumNow ( View Tweet)
post hoc of the PEXIVAS study 704 participants w/ severe ANCA vasculitis: 92% achieved remission & 23% had relapses (rate 10.3/100PYs)-- Neither plasma exchange nor glucocorticoid tapering regimen impacted relapse risk. https://t.co/LKaqptWbxZ https://t.co/nOvE6BqYOl
Dr. John Cush RheumNow ( View Tweet)