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RheumNow Podcast – The Future of JAKs (6.5.20)
Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.
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EULAR and ACR COVID19 Guidelines: Similarities Provide Reassurance
In difficult times, it's reassuring to reflect on the similarities that bring us together. In the case of the EULAR and ACR COVID19 guidelines as discussed at #EULAR2020 by Drs.
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#EULAR2020 OP0096 Dr. L Chatzis study on Sjogren:
1. 2nd most common autoimm dz in women
2. women:men ratio 20:1 (not 9:1)
3. 2 types Ro-Ab: nuc. Ro60 (assc w/La)and cytopls. Ro52 (assc w/ILD/myositis)
4. Seroneg. Sjogren's (neg Ro/La/RF) good prognosis:⬇️lymphoma
@RheumNow https://t.co/fV3ltQqnkf
k dao KDAO2011 ( View Tweet)
NPSLE is more than a headache! probs with dx, uncertain Rx, overlap with common probs - infection, pain, fibromyalgia, drug side effects, etc. Spectrum in NPSLE just like SLE has a spectrum of cutaneous findings T Huizanga discusses @eular_org #EULAR2020 @RheumNow @CRASCRRheum https://t.co/sdw0xavWBq
Janet Pope Janetbirdope ( View Tweet)
When making a dx of neuropsychiatric SLE I order labs AND @RheumNow @eular_org @CRASCRRheum @earlyarthritis #EULAR2020
Janet Pope Janetbirdope ( View Tweet)
MTX in GCA (+/- TCZ): can GiACTA data provide insights?
MTX didn't add anything from data provided, but channelling bias a definite issue (note PNL numerically higher in non-MTX).
MTX as adjunct/cover post-TCZ? We'll need to test for it properly
FRI0220 #EULAR2020 @RheumNow https://t.co/BCsEKqqaMh
David Liew drdavidliew ( View Tweet)
I've heard people say FDG uptake on PET/CT in PMR/GCA is just a correlate of systemic inflamm.
Look at the uptake intensity (SUVmax) vs inflamm markers in n=65 PET/CT in GCA. There's no pattern whatsoever.
Not just an expensive ESR!
@FreemanHospital SAT0272 #EULAR2020 @RheumNow https://t.co/D4xAZC7KmO
David Liew drdavidliew ( View Tweet)
To truly address adherence, you need to understand what is impairing it, and tailor an approach to overcome those barriers.
Great to see this articulated in EULAR recommendations re: non-adherence - a big factor in our therapeutic outcomes!
EULAR projects #EULAR2020 @RheumNow https://t.co/0pazcDFTuV
David Liew drdavidliew ( View Tweet)
Is there subclinical GCA in PMR pts?
50 consecutive PMR pts had vascular USS. 27/50 had GCA vascular uptake, of which 10 had no GCA symptoms at all.
Is PMR sometimes just the tip of the GCA iceberg? Do the aSx USS+ pts get GCA Sx eventually?
Bonn SAT0254 #EULAR2020 @RheumNow https://t.co/UmsixY29Qh
David Liew drdavidliew ( View Tweet)
GCA and cancer: it's been hard to tease apart, lots of cofounders. We've needed large cohorts with comparators & detail.
Large Israeli database says there are links
(EMR/claims/prescribing combined, n = 4.4m w validated incident GCA set). If so, why?
OP0143 #EULAR2020 @RheumNow https://t.co/kSPGnxNjah
David Liew drdavidliew ( View Tweet)
#EULAR2020 Prof. T Domer: baricitinib show promise in phase II trial for SLE: Microarray analysis noted reduction in IFN signature; however, the reduction did not correlate w/SLEDAI-2K or SRI4 clinical response @RheumNow https://t.co/cW4egzSnAs
k dao KDAO2011 ( View Tweet)
#EULAR2020 Most innovative! Vaccination with IFNa-kinoid to induce anti-IFNa antibodies to treat SLE (results of phase IIb trial). https://t.co/rM0z23ieQW @RheumNow https://t.co/OYMdDZl6sb
k dao KDAO2011 ( View Tweet)
#EULAR2020 OP0160 Prospective study of Hopkins Lupus Cohort: HCQ blood levels can predict risk for thrombotic events in SLE. Dr. M Petri advocates this is another reason for monitoring HCQ whole blood levels. Goal HCQ whole blood level should be 1000-1500 ng/mL @rheumnow https://t.co/mM6jsJ2Qmf
k dao KDAO2011 ( View Tweet)
#EULAR2020 OP0163 Updated Lupus Nephritis EULAR/ERA-EDTA Recc:
1. T2T:⬇️proteinuria 50%@6 mo,UPCR<700 mg/g@12mo
2. Class III/IV:MMF, Euro-CYP; MMF+CNI
3. goal pred < 7.5 mg/day@6 mo
4.Class IV: MMF, CNI, CTX
5. Maintain w/MMF, AZP
6.🔃renal Bx w/refract. dz @RheumNow https://t.co/tGaSIDG1ji
k dao KDAO2011 ( View Tweet)
#EULAR2020 Dr. Kimme Hyrich reviews the EULAR #COVID19 Registry "Most individuals with rheumatic diseases receiving immunosuppressive therapies recover from COVID19" @rheumnow https://t.co/EdVLUMyHhF
k dao KDAO2011 ( View Tweet)
#EULAR2020 panel on #COVID19 spec. situatns:
1. German regtry: very few preg rheum pts w/CV19; cases mild.
2. No info how CV19 affects APS
3. Very few ped rheum cases of CV19- cases mild; outcomes sim to gen peds pop
4. Most rheum pts w/CV19 good prognosis @rheumnow https://t.co/LQVdzJKCgu
k dao KDAO2011 ( View Tweet)
#eular2020 #op0302 Ianalumab (VAY736) dual action BAFFreceptor inhibitor/B cell depletion meets primary end point in p2b for pSS: EESDAI⬇️1.92 pts over PBO at wk24. Dis not meet 2ry endpoint ESSPRI&FACIT-F. Good side effect profile w/mild inj site reactions mostly @RheumNow https://t.co/9qsfUNho9h
Olga Petryna DrPetryna ( View Tweet)
New #therapeutic strategies in #SLE management
#EULAR2020 https://t.co/dhvTKd4EGB
dr hanady manasfi hanadymanasfi ( View Tweet)
Our study shows that HCQ retinopathy virtually never occurs in first 5 yrs, SLE has more risk than other diseases such as RA and chloroquine has a far higher risk of retinal toxicity OP0333 #EULAR2020 @RheumNow @CRASCRRheum @earlyarthritis https://t.co/ZzRy3po4yw
Janet Pope Janetbirdope ( View Tweet)
#EULAR2020 OP0167 Results are finally in!!
MMF can be safely w/drawn in quiescent SLE: prospect RCT (nonblinded) 102 pts. MMF tapered over 12 weeks, f/u 60 weeks; no sig diff for flares in pts who stopped MMF vs. maintained; pts who cont MMF had ⬆️ minor infections. @rheumnow https://t.co/bOnuEBLis9
k dao KDAO2011 ( View Tweet)
