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Dr. Jack Cush reviews the lastest journal articles, news, and FDA announcements from the past week on RheumNow. This week, the importance of IFNa, Subclinical PsA and NSAID safety during Pregnancy.
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Periodontal disease (PD) is more common in rheumatoid arthritis (RA), especially those with anti-citrullinated protein antibodies (ACPAs). RA activity has been linked to the severity of PD and mucosal inflammation.
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A BRASS registry study shows that specific isotypes of anti-citrullinated protein antibodies (ACPAs) can be associated with incident rheumatoid arthritis-associated ILD (RA-ILD).
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Dr. Jack Cush reviews the news and tries to stump the expert panel this week on the podcast.
Dr. John Cush
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Managing Septic Arthritis in RA
https://t.co/ccRZLCtl3S https://t.co/wS2KG1jAJl
Dr. John Cush
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ARTIS Swedish study of Cancer in RA or PSA pts (~15k pts) starting JAKi vs TNFi. With ~2 yrs F/U, the risk of Cancer (excluding NMSC) was similar betw JAKi and TNFi (HR 0.94; 0.65 to 1.38), but more incident NMSC w/ JAKi (HR 2.12; 1.15 to 3.89) at 2 yrs https://t.co/BiPWF1T0lZ https://t.co/nrmaCGBcce
Dr. John Cush
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In #RA, Citrullination modulates antigen processing and presentation by exposing otherwise cryptic epitopes https://t.co/aciZe4KG6H https://t.co/i7twPvb5P4
Dr. John Cush
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Periodontal Mucosal Breaks Trigger RA Disease Activity
Periodontal disease (PD) is more common in RA, especially those with anti-citrullinated protein antibodies (ACPAs). RA activity has been linked to the severity of PD and mucosal inflammation.
https://t.co/eTDNqlOHyp https://t.co/VZoeqJmsr0
Dr. John Cush
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Metanalysis of 25 studies, betw 1985 - 2021, showed US average annual visits for RA=5.25 for US rheums (vs 3.3 ex-US) & 4.8 US non-rheums. SLE=3.24 & 12.3 for US non-Rheums. FM=1.8 for US rheums & 0.4 vs ex-US Rheums. Rheum Visits Decreased 1982 to 2019 https://t.co/WIXDXUCG60 https://t.co/s7W9gcd5dd
Dr. John Cush
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National study of 184,722 #RA pts (182 RISE sites) shows High % of socially deprived, high comorbidity, Medicaid- RA pts mainly in the south; <10% of Rheum practices cared for >50% of Medicaid RA pts. Moderate correlation betw comorbidity & Dz activity https://t.co/dsjH78cJqp https://t.co/U3l2m566d1
Dr. John Cush
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Chest Pain & Fever
Lessons from the clinic, brought to you by https://t.co/4UQlqwujiR March 18 &19, 2023 - Dallas, TX
https://t.co/6iMT1Tt7KR https://t.co/owui66FMPJ
Dr. John Cush
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Comparing ACR21 vs EULAR22 RA Guidelines
https://t.co/dLtEaUBTKM https://t.co/Rang58z2N2
Dr. John Cush
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Specific ACPAs and Autoantibodies Lead to RA-Associated ILD
https://t.co/AuTDGt8gYJ https://t.co/Q1rKdxkbLZ
Dr. John Cush
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Metanalysis of 25 studies, betw 1985 - 2021, showed US average annual visits for RA=5.25 for US rheums (vs 3.3 ex-US) & 4.8 US non-rheums. SLE=3.24 & 12.3 for US non-Rheums. FM=1.8 for US rheums & 0.4 vs ex-US Rheums. Rheum Visits Decreased 1982 to 2019 https://t.co/5ugk34MJ3b https://t.co/NDMYZT7pil
Dr. John Cush
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Specific ACPAs and Autoantibodies Lead to RA-Associated ILD
https://t.co/KLq3CYc20P https://t.co/G7u36CWOTn
Dr. John Cush
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S.Korean population based study shows the frequency of pregnancy induced de Quervain's tenosynovitis (DQT) between 2013-17 was 2.1% of all preg women. Risk factors: ≥ 30 yrs, multiple gestation, C-Section, HTN in preg, RA (DM not a risk) https://t.co/JaOQhaX5rL https://t.co/cl6RZLfXds
Dr. John Cush
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Steroids assisting options - CTX, LEF or RTX @anisha_dua @RWCSmtg @RheumNow #RWCS23 https://t.co/gVw2tGKYNG https://t.co/ItIKB8MFTI
Dr. John Cush
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Implantable Vagal nerve stimulation studied in 17 active #RA pts DAS ~6. Dr Eric Ruderman #RWCS23 https://t.co/GgjdcfuVud https://t.co/EpuGgApOq5
Dr. John Cush
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Does Methotrexate Increase Skin Cancer Risk?
A report from the British Journal of Cancer has also shown an increased risk of basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) with MTX use; and more so with higher doses.
https://t.co/8AkdkrZs44 https://t.co/ZXrqlbZiZV
Dr. Rachel Tate
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Have you heard of nipocalimab? It prevents IgG-FcRn by binding to the FcRn IgG binding site. This is one to watch in our diseases (RA, Sjogren’s, SLE, myopathies.) Dr. Postolova #RWCS23 @RheumNow @RWCSmtg https://t.co/qMGA6IdtUE
