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What is JAKne? (5.6.2022)

Jack Cush, MD

Dr. Jack Cush reviews the news, journal reports, FDA actions, new side effects and changing prevalence of Gout.

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medical.marijuana

Lack of Research Stymies Uptake of Medical Marijuana for Rheumatic Pain

Creaky Joints

A new review article from CreakyJoints finds that there has been limited progress in understanding the potential of cannabis based therapies for the treatment of pain associated with rheumatic conditions in the past five years because of a lack of standardization of clinical research and barriers to conducting research due to existing federal and state regulations.

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DMARDs,biologics,RA

Efficacy of Subsequent b/tsDMARD Use in Rheumatoid Arthritis

Jack Cush, MD

Analysis of rheumatoid arthritis (RA) data from the British Society for Rheumatology Biologics Register shows that, even after failing three or more biologic or targeted synthetic DMARDs (b/tsDMARDs), patients may continue to benefit from repeated trials of unused b/tsDMARDs. 

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RA, hands, MCP, deformity

Trends in Rheumatoid Arthritis Disabililty, Despite Biologics

MedPage Today

Disability claims in the U.S. related to rheumatoid arthritis (RA) were just as common in 2015 as in 1999, a government researcher found, against expectations that the advent of biologic therapy would have led to a steady decrease.

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$30 Billion and Counting (4.29.2022)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports and takes viewer questions this week.

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JIA.oligoarticular.jpg

Biologics for JIA? Not So Fast, Say Insurers

MedPage Today

It's not a simple matter to prescribe tumor necrosis factor (TNF) inhibitors for patients with juvenile idiopathic arthritis (JIA), at least those with insurance, a single-center study found.

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Liver,hepatic,red

Arthritis Predicts Hepatic Fibrosis in Hemochromatosis

Jack Cush, MD

Mayo Clinic Proceedings reports the results of a retrospective, cross-sectional of patients with HFE hemochromatosis showing that advanced hepatic fibrosis is primarily seen in those with arthritis due to HFE hemochromatosis. 

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Efficacy of Subsequent b/tsDMARD Use in Rheumatoid Arthritis https://t.co/5dXe0AdNzE https://t.co/eS4KdaKBmC

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Dr. John Cush RheumNow ( View Tweet)
An increasing incidence of RA is driven by increasing # of ACPA-negative RA (but not ACPA-positive RA), partly explained by an ageing population (thus making ACPA-negative RA more prevalent in coming years) https://t.co/9vC8aCphKc

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Dr. John Cush RheumNow ( View Tweet)

Trends in RA Disability, Despite Biologics Disability claims in the U.S. related to RA were just as common in 2015 as in 1999, a gov't researcher found, against expectations that the advent of biologic therapy would have led to a steady decrease. https://t.co/vyyjTbkLN2 https://t.co/D5Eo42P4cw

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Dr. John Cush RheumNow ( View Tweet)
Study of 17 homeless RA or PsA pts - less clinic access (80% vs 91%), more ED use (20 vs 5), less DMARDs (43% vs 100%), more steroids (29% vs 0%); 83% unable to work due to health. Greatest need - dental , PT, knee surgery, employment & housing https://t.co/VHnTR0MTkr https://t.co/JDZTELz2qB

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Dr. John Cush RheumNow ( View Tweet)
There is 1.4 million transgender persons in the US. ACP has published a guideline "Care of the Transgender Patient" addressing health disparities, certain cancers, substance abuse, mental health conditions, infections, and chronic diseases. https://t.co/AoBeOzv9YH https://t.co/jKabVELPxH

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Dr. John Cush RheumNow ( View Tweet)
Efficacy of Subsequent b/tsDMARD Use in Rheumatoid Arthritis https://t.co/n1O4g4HpMM https://t.co/ulF1d2gDkG

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Dr. John Cush RheumNow ( View Tweet)
Did you miss last night's TNR on RA, improving future therapy? We've got you covered. Listen to the playback here. https://t.co/ci6TZOw3VX https://t.co/31gRUaKbQm

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Dr. John Cush RheumNow ( View Tweet)
Neural networks of high-res quantitative CT (HR-pQCT) scans allowed for 3D imaging of MCP2 to differentiate normals from #RA & #PsA. 932 of 617 ppts correct AuROC for HC 82%, RA 75%, PsA 68%. UA pts read as 86% RA,11% PsA, & 3% HC https://t.co/wSQgllYgug https://t.co/yA6g55SpeC

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Dr. John Cush RheumNow ( View Tweet)
Rheumatologic diagnosis through hand exam by Dr. Sarah Chung @ACPinternists #rheumatology #rheumtwitter #MedEd #rheumatoidarthritis #BJHM #Hospitalmedicine #IM2022 #MedTwitter 👇🏽 https://t.co/qR4zNa4NcX
Brown Journal of Hospital Medicine BrownJHM ( View Tweet)
Leflunomide responses in #RA assoc w/ high metabolite levels (A77 1726). In 115 LEF Rx Pts, 40% had LDAS/remission. A77 1726 levels neg correlation w/ DAS28-ESR (r = − 0.42, p < 0.001). Levels >10µg/mL & LDAS PPV 70%; NPV 93% https://t.co/V32wUGVWLM https://t.co/L9DwZBwet9

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Dr. John Cush RheumNow ( View Tweet)
Study of 33 #RA pts finds nearly half had peripheral neuropathy (48.5%); sensorimotor in 64.7%, motor in 17.6%. Neuropathy was NOT associated with age, gender, disease activity, functionality, or falls https://t.co/r2aQI2cm27 https://t.co/OOQlWkCAft

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Dr. John Cush RheumNow ( View Tweet)
Systematic literature review of studies where steroids were used as initial "Bridge Therapy" in RA patients - included 10 studies, but only 4 RCTs w/ protocolized discontinuation - these showed 22% were still on GC @ 12 mos, 10% @24 mos https://t.co/aRLhptAASe https://t.co/lg4msIyQfc

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Dr. John Cush RheumNow ( View Tweet)
COVID-19 Vaccination Uptake and Perceptions in Rheumatic Patients Putman et al has reported vaccine survey results from the C19-GRA in Lancet Rheumatology showing the uptake and vaccine hesitancy among people with rheumatic diseases (RMD). https://t.co/sqsOHGThzV https://t.co/zeZrlDeQ9Z

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Dr. John Cush RheumNow ( View Tweet)
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