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NEJM has published the interim analysis of the REGN-COV2 trial, wherein an antibody cocktail reduced viral loads with less clinical consequences.
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JAMA has published the BLAZE-1 study, showing significant SARS-CoV-2 viral load reduction at day 11 and less COVID-19 progression when combination anti-spike monoclonal antibody therapy (bamlanivimab and etesevimab) was given to mild to moderate, non-hospitalized COVID-19 patients.
Dr. John Cush
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A serious shortage of pediatric rheumatologists in the USA, where we need at least 1 ped rheum per 400,000 population. @RWCSmtg https://t.co/o8XCkjUOaN
Dr. John Cush
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Dr George F Still, among the first to write about children with arthritis, pediatric Rheumatology, in 1898, with his description of 22 kids with arthritis. @RWCSmtg https://t.co/Y6DOzooFjZ
Dr. John Cush
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Congrats to ACR Task Force who published guidelines on RMD drug use w/ COVID vaccines. My views on their recs:
1. I agree, no change most DMARD, biologics
2. I disagree; I would NOT hold Orencia, I would NOT hold JAKi
3. I disagree: I would not hold MTX https://t.co/uSPfvJB8EC https://t.co/SznUJosmpo
Dr. John Cush
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IVIg in MIS-C
Among children with multisystem inflammatory syndrome (MIS-C), treatment with IVIG and methylprednisolone vs IVIG alone was associated with a more favorable fever course.
https://t.co/iCyJd3bbao https://t.co/edgVLpMP5a
Dr. John Cush
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QD Clinic - What Were You Thinking
Pet Peeve Issues in Patient Care
https://t.co/BpjXbsdWr5
Dr. John Cush
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Congratulations to Dr. Daniel Kastner for winning the 2021 Crafoord Prize in Polyarthritis, “for establishing the concept of autoinflammatory diseases.” The Royal Swedish Academy of Sciences and the Crafoord Foundation issue this award annually. https://t.co/yj218sGcwG
Dr. John Cush
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2016 Deloitte report on top 10 healthcare innovations (Spot on!):
1 Next gen sequencing
2 3-D printing
3 AI
4 Immunotherapy
5 Point of care diagnostics
6 virtual reality
7 social media for Pts
8 Biosensors/trackers
9 Telehealth
10 Convenient care https://t.co/yWaqzM9pFC
Medicine Matters rheumatology
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News: #COVID19 risk may be reduced with #biologics and #JAKinhibitors, but increased with #glucocorticoids, Italian researchers report in @ArthritisRes https://t.co/zIef2aNCns
Dr. John Cush
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QD Clinic - Dadgummit, Where's Waldo's COVID Vaccine?
My rant on the COVID vaccine unavailability, and what we can - and can't - tell patients.
https://t.co/VKrDgvuXqt https://t.co/zuNe8lEaR4
Dr. John Cush
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Rheumatologists Rank 2nd in Physician Burnout
The 2021 Medscape Survey on Physician burnout ranks rheumatology second, just behind Critical Care medicine.
https://t.co/nIDqa5TCqG https://t.co/psem4wYIlN
Dr. John Cush
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QD Clinic Week Of 1.17.2021
Myalgias & Arthralgias, Smoking and RA, The Dastardly, nastardly facts of smoking and RA, Oivay the Elevated ESR
https://t.co/hTQ46YZTzG
Dr. John Cush
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COVID Vaccine Q & A - Dr Kevin Winthrop Dr. Cush interviews Dr. Kevin Winthrop (OHSU) on the use and caveats to COVID-19 vaccination in patients with rheumatic disease and taking biologic and DMARD therapies https://t.co/EJL6hVLnrp https://t.co/XOHk9T04rx
Dr. John Cush
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Ehlers-Danlos Syndrome pts have higher association with GI conditions (IBS, etc OR =3.57), POTS & Autonomic dysfunction (OR=4.4), food allergy (OR= 3.9), CV complications (OR 6.1; MV dx, aortic aneurysm), longer hospitalizations (OR= 1.76) https://t.co/noobvrx0cQ
Dr. John Cush
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Though provoking piece by Dr. Len Calabrese in Healio,He references Drs. Schett and Scher writing in Nature Reviews Rheumatology on KOLs. Both articles are about reflection on what we do, how we do it, what motivates us. Good Reads https://t.co/HDlFRVJq1a https://t.co/CtqqiZuxwo
Dr. Janet Woodcock
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My note to the FDA staff: https://t.co/n2Pr2Kzrre
Dr. John Cush
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UTSW Rheum Grand Rounds - IgG4 Dz - Plasmablasts may be a useful biomarker; but is not generally available in clinical labs (must be done on fresh whole blood) @UTSWIMchief https://t.co/GlEKw0KD3O
Dr. John Cush
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UTSW Rheum Grand Rounds - IgG4 Dz commonly presents as major salivary and lacrimal gland enlargement, orbital disease, autoimmune pancreatitis, retroperitoneal (mass) fibrosis or tubulointerstitial nephritis. @UTSWIMchief
Dr. John Cush
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Being "busy" is about priorties and productivity.