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VITAL Study - Autoimmune Prevention Requires Continued Supplements
In the 2 years that followed the termination of the VITAL study, the preventative effect of vitamin D on incident autoimmune disease disappeared with supplement discontinuation; but n-3 fatty acid treated individuals had a sustained benefit in reducing the risk of autoimmune disease.
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Determinants of Gout Flares
Approximately 12 million US adults in the US have gout. Two recent literature reports highlight contributors to gout flares.
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Racial and Ethnic Determinants of Psoriatic Arthritis
A study from a large metropolitan registry of psoriatic arthritis (PsA) patients showed several racial and/or ethnic groups are underrepresented and demonstrate differences in disease activity.
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Acute CPPD at significantly higher risk of fractures. 1148 acute CPPD pts matched to 3730 comparators(mean 73 yrs old); Steroids and OP more in CPPD pts. Fx risk was twice as high in the acute CPPD pts (HR 1.8;1.3, 2.3). Fx risk highest forwrist (HR, 3.6) https://t.co/25EOzXI0sH https://t.co/c1Xiq8TaUP
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Racial and Ethnic Determinants of Psoriatic Arthritis
A study from a large metropolitan registry of psoriatic arthritis (PsA) patients showed several racial and/or ethnic groups are underrepresented and demonstrate differences in disease activity.
https://t.co/lHQxchTSyU https://t.co/AcXcpvuGI8
Dr. John Cush RheumNow ( View Tweet)
Join our experts, Drs Liebowitz and Mehta, as they provide insights on the differential diagnosis and management concepts in autoinflammatory diseases.
https://t.co/KooVTScHvd https://t.co/RemKaT5ROn
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Autoimmune disease and pregnancy
For many aspiring mothers with autoimmune disease, pregnancy can be daunting and full of unknowns. I
https://t.co/HtXEH3S0CQ https://t.co/G0fYlgble0
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Danish registries study shows maternal Autoimmune Dzs (all) were assoc w/ incr risk of childhood cancers (OR=1.25, 95% CI 1.06, 1.47), acute lymphoblastic leukemia (OR =1.52), Burkitt lymphoma (OR=2.6) & CNS tumors (OR=1.45); same seen for RA mothers https://t.co/VCgwQRSLEY https://t.co/OmB8XPH7n7
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Study of 78 #RA pts(83% CCP+) showed signif. discordance between office visit DAS scores & telephone eval by RAPID3 (w/in 2 wks of F2F visit). By RAPID3, 27% were in remission, vs F2F DAS-CRP 71%) or DAS-ESR (33%) kappa= 0.48 (mod) & 0.14 (low agreement) https://t.co/DsgR0aMUGf https://t.co/smnFe13m5W
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Metanalysis of 14 RCTs (602,760 pts) showed a higher risk of venous thromboembolic events in #RA- w/ significant 57% increased risk compared to general population:
VTE (RR 1.57)
DVT (RR 1.58)
PE (RR 1.57)
https://t.co/vCCMe46NNP https://t.co/c204ga4v01
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Leaving Academia
Dr. Jack Cush reviews the news and journal reports from the past week on https://t.co/V10S4oVFsv. This week we discuss hipsters undergoing hip replacement, pregnancy outcomes in RA and the future of academic clinicians.
https://t.co/cuENQxlSOt https://t.co/olMihVm4bU
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SeXXist Reason for More Women with Autoimmune Disease
Somewhere between 24 and 50 million Americans have an autoimmune disease, a condition in which the immune system attacks our own tissues. As many as 4 out of 5 of those people are women.
https://t.co/RO7k5BGXci https://t.co/z5YdE59gTq
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Pre-Treatment Testing with Biologics Falls Short
US commercial insurance claim analysis of lab screening and monitoring practices in CISD patients shows that < 60% received the reco pretreatment testing when starting systemic immunomodulatory treatment.
https://t.co/WdI3xfMyng https://t.co/xxKVkag60o
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Korean Database study of 1796 #AS pf (vs 7184 controls 1:4 ratio); 9.3% develeoped cancer; AS pts have no overall increase in cancer risk (aHR 1.1); AS pts had higher risk ofupper GI cancer (HR: 1.51) & hematologic CA (aHR: 2.36). Is there an NSAID effect? https://t.co/6W68upVQrn https://t.co/RWlhLFV9EJ
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Telemedicine in MSK - systematic review of 35 studies (2015-22); 69% of low quality. Most found telemedicine to be equal or better by PROMs (vs F2F care). All showed notably lower costs for telemedicine compared to in-person visits. https://t.co/eA8QEzhJGZ https://t.co/h65WMDXjQN
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Since April 2017, DEA Take Back (drugs) campaign has spread to 17,000 locations where your patients can safely dispose of narcotics or unsafe drugs. Find your Everyday Drop-Off center by clicking here: https://t.co/uZPtFtXk6a https://t.co/dRalITYyfV
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No evidence of harm starting urate lowering Tx (ULT) during #gout attack. Metanalysis 6 RCTs (445 pts) w/ gout attacks given ULT vs PBO or delayed ULT. No differences in pain, time to resolve gout flare or risk of recurrent gout flare in 30d (RR 1.06) https://t.co/Zk6OjJ8I2F https://t.co/prBQeSYH2Y
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Study of 235 newly Dx #RA patients (157 females) found that 11 pts (5%) had carpal tunnel syndrom (CTS) at the time of initial RA diagnosis. Such pts were more likey to be older, female, CCP negative and have a longer Sx duration. https://t.co/Nny9HSD5zX https://t.co/2Dnhrjz8ud
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240 consecutive estab. RA pts underwent cervical spine X-rays looking for ant. atlantoaxial subluxation (aAAS >3 mm); aAAS found in 25 (10.4%) mean interval =4.2mm. One-third had no neck pain. aAAS predicted by lower BMI, CCP, erosions & joint prostheses https://t.co/VTMdv6wudB https://t.co/RDbjjuJAjD
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Full read, great review of JAK/STAT signaling and JAK inhibitors published in Ann Rheum Dis.-- Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story (Authored by JAK mavens) https://t.co/xen1Htkv2o https://t.co/5hX9hhuK77
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