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Lovastatin Fails to Lower CRP and Activity in RA

Jack Cush, MD

Ridker and colleagues have shown that statins (3-hydroxy-3-methylglutaryl coenzyme-A (HMG Co-A) reductase inhibitors) are effective at treating hyperlipidaemia and lowering C-reactive protein levels; Aranaow and colleagues have shown that lovastatin, when given to rheumatoid arthritis (RA) patients with elevated CRP levels failed to significantly lower disease activity. 

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NIH taps Dr. Lindsey Criswell as the New Director of the National Institute of Arthritis and Musculoskeletal and Skin Diseases. She was the vice chancellor of research and a professor of rheumatology at UCSF. She begins in early 2021. Congrats!! https://t.co/H1wpYHOOWg
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Virtual Video Joint Exam Pearl #5: The worst/most ineffective Virtual visits done with the Patient (or MD) driving in their CAR for the virtual visit!! Amazingly I have had a half dozen of these & requested the patient pull over so I could deliver a rheum Citation.
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The only thing worse than bad covid research is a meta-analysis of bad covid research
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Analysis of administrative health data (1984‐2016) on 12984 #RA pts shows RA w/ psychiatric comorbidities (depression, anxiety, bipolar, schizophrenia) had more additive visits (10.9), hospitalizations, hospital days (3.6), more drugs (7.3) & FP visits https://t.co/5py0i2tWqL
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Down syndrome-associated arthritis (DA) presents as a seronegative erosive polyarthritis. Besides an Avg 19-month delay in Dx, most are treated same as JIA but JIA agents are often poorly tolerated & less effective in DA. Prevalence=8.7/1000 Downs kids https://t.co/hEtAbo2tY6
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FDA has issued draft guidance on Cannibis research: “Cannabis & Cannabis-Derived Compounds: Quality Considerations for Clinical Research, Draft Guidance for Industry,” outlines FDA’s current thinking on clinical research related cannabis-derived compounds https://t.co/ppvisN1oxU
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Systematic review of 100 pts with statin-associated myopathy showed mean age 65 yrs, presenting w/ symmetric prox. muscle weakness, mean CK=6853 IU/l, all were HMG-CoA reductase Ab+ & >80% had necrotizing myopathy & required immunosuppressants https://t.co/BoNmOHPkGH
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One-third of hospitalized COVID-19 patients have evidence of pulmonary embolism by CT scan. Retrospective study 1477 hospitalized COVID-19 pts; diagnostic yield of Chest CT for PE was 37%, w/ higher Ddimer in PE pts. https://t.co/jxy7FF5143
Mohammad A. Ursani MD, RhMSUS Tweet
DrMAUrsani
#Texas we REALLY need to #WearAMaskSaveALife ... 6 patients of mine have tested positive for #COVID19 in the last week. #MedTwitter @rheum_covid @COVID19Tracking
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Registry of COVID CNS complications reports 125 pts; 77 (62%) w/ Cerbrovascular event (57 ischemic CVA), 9 intracerebral hemorrhage, 1 CNS vasculitis. 39 w/ AMS, 9 encephalopathy & 7 encephalitis. 10 new-onset psychosis, 6 dementia, 4 affective Dz https://t.co/mXyTHIFBIE
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Regeneron/Sanofi have reported their US phase 3 trial of Kevzara (sarilumab) 400 mg given to 194 critically ill COVID-19 patients, requiring mechanical ventilation, did not meet its primary and key secondary endpoints when added to supportive care. https://t.co/UPfGJKWEM9
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Who you gonna call? Fauci that's who. Listen to Fauci LTF! LTF!
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