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Sodium Channels, Carbemazepine and Osteoarthritis Progression
A study published in Nature suggests that therapies affecting sodium channels could be employed to treat osteoarthritis.
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SLE: A Mutated Gene and TLR7 Overexpression
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EurekAlert!
A group of researchers lead by Min Ae Lee-Kirsch from the Department of Pediatrics, Medical Faculty, TUD Dresden University of Technology (Germany), studied four patients from two families who developed symptoms of SLE in the first years of life.
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2023 Rheumatology Year in Review
Dr. Jack Cush reviews highlights, advances and hot topics in rheumatology from 2023 and the RheumNow website.
2023 was a year of growth and new horizons while returning to operational and practice standards (in care and education) established before the pandemic.
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Increased CV Comorbidity in Dermatomyositis
A cohort study suggest that patients with dermatomyositis (DM) are at an increased risk for multiple comorbidities, including chronic kidney and cardiovascular disease,
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European ustekinumab (Stelara) biosimilar Uzpruvo® (AVT04) was granted marketing authorisation by European Commission & will be available in July 2024. US FDA approved Wezlana (ustekinumab-auub) in 11/2023. https://t.co/Wv2Z7P5xAu https://t.co/PdGEUpyRU6
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SLE: A Mutated Gene and TLR7 Overexpression
A group of researchers studied four patients from two families who developed symptoms of SLE in the first years of life.
https://t.co/ggr1nMQnh0 https://t.co/c6IoJlgida
Dr. John Cush RheumNow ( View Tweet)
2023 Rheumatology Year in Review
Dr. Jack Cush reviews highlights, advances and hot topics in rheumatology from 2023 and the RheumNow website
https://t.co/5Y9ezzS5zC https://t.co/pqpMR8jDlk
Dr. John Cush RheumNow ( View Tweet)
Real-world data of 5070 RA pts (1816 Rx w/ b/tsDMARDs) showed the use of tsDMARD considerably increased from 2012 to 2021. All b/tsDMARDs pts improved Dz activity & function/ 10 yr effiicacy best for IL6Ri in switch pts and ABA in bNAIVE pts https://t.co/h9j8Pk03if https://t.co/gC7Wloujm0
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Metanlysis of 49 studies, 10 RCTs examined the relationship between RA and non-surgical Rx of periodontitis (NSRT) and in general short term studies show that NSPT benefits RA patients; and DMARD therapy benefits periodontitis https://t.co/HeBA6xtw2O https://t.co/J2QUYVk3gE
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Heritability of Osteoarthritis
A Swedish study examine the genetic contribution to various rheumatic/musculoskeletal diseases (RMDs) and showed that osteoarthritis (OA) had a large heritability compared with other RMDs.
https://t.co/KbQDQ1mB53 https://t.co/opLrlRit2W
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Bidirectional relationship betw Autoimmune disease (AD) & perinatal depression (PND); 1:10 case control study of 1.3 milion pregnancies & 55,299 incident PND found AD preg w/ a 30% (OR 1.3) higher risk of PND & PND had a 30% ^ risk (OR 1.3) of AD https://t.co/zkwIo6liC7 https://t.co/Sy1HPLLeva
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Experience the Future of Rheumatology at RheumNow Live 2024, just two weeks away!
Don't miss out – secure your spot today for an unforgettable journey into the latest advancements and insights.
https://t.co/bbnb97MOHO https://t.co/QXO34ZmP2i
Links:
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QD Clinic - ANA Positivity in RA
Considering an ANA+ Seropositive RA Patient
https://t.co/q0g0JsSWGu https://t.co/nXcEZbbEXG
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Enthesitis, Synovitis, and Tenosynovitis in Psoriatic Arthritis
An ultrasound study suggests that enthesitis is associated with both synovitis and tenosynovitis in patients with Psoriatic arthritis (PsA).
https://t.co/c9z0nsABe0 https://t.co/Ez4i8qCcJ8
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Curcumin therapy for knee osteoarthritis
Curcumin is widely used in traditional Chinese medicine to treat arthritis and is presumed to have analgesic and antiinflammatory effects that may benefit those with osteoarthritis, particularly KOA.
https://t.co/a8JscOOhmz https://t.co/j1htFQkfnD
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Hydroxychloroquine Overview (full read)
History, PK/PD, MOA, Clinical Benefits, dosing, Adverse events covered.
https://t.co/oJcM5ewOBh https://t.co/UaUiH7rpfM
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2023 Rheumatology Year in Review
Check out my top 10 list (in no particular order) of 2023 advances, game-changers, and developments that changed, or will soon change, rheumatologic practices.
https://t.co/UaaAd8pcpM https://t.co/8EIkMeunyZ
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Hormonal Status Increases RA Risk
Early menopause—before the age of 45—taking hormone replacement therapy (HRT), and having 4 or more children are among several hormonal and reproductive factors linked to a heightened risk of RA in women.
https://t.co/Rz6rzkOHV5 https://t.co/UYjgs0MBv5
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Full read review of Catastrophic Antiphospholipid Syndrome (CAPS) https://t.co/J1kOJYv1Cl https://t.co/cJQagQmEp6
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Retrospective study 127 suspected #GCA w/ negative temporal artery Bx - 73 finally Dx w/ GCA & 61/73 were FDG PET-CT pos.(84%). In 54 nonGCA, FDG PET-CT was positive in 8 (15%). FDG-PET sensitivity 84% (100% extracranial LV-GCA), specificity of 85%. https://t.co/Uc8dbdzIil https://t.co/z2d7h6jCFP
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