All News
New Hope for Hand Osteoarthritis
EurekAlert!
The drug talarozole – which increases retinoic acid – could be a promising new treatment for hand osteoarthritis.
Read Article
Metformin Reduces Osteoarthritis Risk in NIDDM Patients
EurekAlert!
Osteoarthritis is a common chronic condition that usually causes joint pain and can be severe enough to require knee and hip replacements.
Read Article
Multi-ancestry analysis reveals novel genetic loci associated with Osteoarthritis
The first large multi-ancestry genetics study of osteoarthritis (OA) has found 10 novel OA-associated genetic loci, and results showed some of the OA-associated regions are robustly found in every population ancestry studied.
Read Article
How Underweight Women Can Reduce Hip Fracture Risk
EurekAlert!
How women can reduce the risk of hip fracture?
Read Article
Marginal Benefit with Diet and Exercise in Obese Knee Osteoarthritis Patients
The easiest intervention for knee osteoarthritis (diet and exercise) is also the most difficult for many patients; but do these work?
https://t.co/s4Gzmh2gGZ https://t.co/aZORTMtCvs
Links:
Dr. John Cush RheumNow ( View Tweet)
#OA phenotypes by SF cell status
- Activated: hi T-cell, low mono–macrop-PMN activated; 70% improved
- Lymphoid: hi PMN, low lymph & mono, low activ, lower pain
- Myeloid: hi NK & mono, low T-cell & activat
- Aggressive: hi lymph/macr/NK/PMN;39%improve
-https://t.co/3DXPoDE5Pm https://t.co/VRJkscAm5a
Links:
Dr. John Cush RheumNow ( View Tweet)
In pts undergoing hip or knee arthroplasty for OA, aspirin (3.45%) compared with enoxaparin (1.82%) resulted in a significantly higher rate of symptomatic VTE within 90 days, defined as below- or above-knee DVT or pulmonary embolism https://t.co/7hgLbynNx6 https://t.co/HMc4UbMcdy
Links:
Dr. John Cush RheumNow ( View Tweet)
Steroid injections worsen knee arthritis
Two studies comparing injections commonly used to relieve the pain of knee osteoarthritis found that corticosteroid injections were associated with the progression of the disease.
https://t.co/pAeU3IzZfx https://t.co/rgJeHM5t62
Links:
Dr. John Cush RheumNow ( View Tweet)
Open label trial compared arthroscopic repair to PT in 100 young pts w/ traumatic, MRI proven meniscal tear without knee OA. Outcomes at 24 months - both groups improvved and were not different between groups https://t.co/rbrUAWuKRa https://t.co/OaNTssAvCG
Links:
Dr. John Cush RheumNow ( View Tweet)
How much does diet and exercise help in knee osteoarthritis?
Pragmatic RCT (WE-CAN), n=823
a diet & exercise intervention program led to:
- 10kg weight loss
- some significant pain improvements
We need to fund diet & exercise programs for OA patients!
ABST1675 #ACR22 @RheumNow https://t.co/Ctm8ZoRF3o
David Liew drdavidliew ( View Tweet)
WE-CAN pragmatic RCT on community-dwelling ♂️&♀️ >/=50y w/ knee #osteoarthritis & obesity:
💠Diet + exercise = significant weight ⬇️and ☑️WOMAC pain score, WOMAC function, 6min walk distance & SF-36 HRQoL
🍽️+🚶♀️in OA? = Yes we can!
#ACR22 @RheumNow @rheumarhyme https://t.co/Ty2boH52HC
sheila RHEUMarampa ( View Tweet)
Ab1675 #ACR22 WE-CAN - Knee OA
823 randomized pts, 18 mo: Intensive Diet & Exercise (D+E)
Primary endpt: WOMAC pain - 32% reduct in pain in D+E, vs 24% (PBO)
20% more likely: clinically meaningful improve
Improved BMI, 6MW, HRQoL, activity
Pain Rx, depression: no change
@RheumNow https://t.co/Su2g4Z38FV
Eric Dein ericdeinmd ( View Tweet)
Does diet & exercise work for knee pain in #osteoarthritis? Pragmatic trial in 3 community sites. 823 RCT, 80% completed -control was education &meetings vs diet&exercise;more intense. 101kg, 77% F, age 65. Diff modest-favoured diet & exercise-works a bit #ACR22 @RheumNow #1675 https://t.co/akjEjVprJl
Janet Pope Janetbirdope ( View Tweet)
Plenary session III:
Intensive diet and exercise program in overweight/obese pts with knee OA showed significant reduction in weight, pain and function, greater walk distance and quality of life.
Abs#1675 @RheumNow #ACR22 https://t.co/vstfJahLQV
Robert B Chao, MD doctorRBC ( View Tweet)
Messier et al. WE-CAN pragmatic trial of diet and exercise (vs attention control) in knee OA with high BMI. Significant improvement in pain, walk distance, SF-36 with corresponding reduction in body weight @RheumNow #ACR22 Abstr#1675 https://t.co/uSSzx4u2sp https://t.co/upnIVecRjv
Richard Conway RichardPAConway ( View Tweet)
In overweight and obese patients with knee OA, 18-months of diet and exercise delivered in community settings significantly reduced WOMAC knee pain (-0.6) compared to an attention control group. Messier S Abs#1675 https://t.co/GvPCGz0NMN #ACR22 @RheumNow https://t.co/yWAwGwunzT
Dr. Antoni Chan synovialjoints ( View Tweet)
Promising data on denosumab in erosive OA
Phase 2 study - less erosive progression, more symptom improvement
Abs# L05 @RheumNow #ACR22 https://t.co/9Fg3r02ZQG
Robert B Chao, MD doctorRBC ( View Tweet)
Wittoek et al. 48-week RCT of Denosumab in erosive hand OA. Prevents structural progression! @RheumNow #ACR22 Abstr#L05 #ACRbest https://t.co/CI6VBERSmn https://t.co/OszJkGeJF7
Richard Conway RichardPAConway ( View Tweet)
L05 #ACR22 High-dose Denosumab in Erosive Hand OA
48Wk, Double-blind PBO Phase 2 100 patients
GUSS change higher in DEN v PBO at w24, incr at w48
New erosions lower in DEN w48 (2% v 7%, OR 0.23, p<0.001)
Open label extension w improvement to baseline
@RheumNow https://t.co/X6MF9q2bKj
Eric Dein ericdeinmd ( View Tweet)
Walrabenstein et al. RCT of 16-week triple intervention - plant-based diet, exercise, stress management - vs usual care in OA. It works, but we don't know which component, or if Hawthorn effect @RheumNow #ACR22 Abstr#1644 https://t.co/p74Ptd8bZ2 https://t.co/EOg7RxRmO7
Richard Conway RichardPAConway ( View Tweet)
