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Industry Abstract Previews - ACR2020

Jack Cush, MD

Each pharmaceutical company has spent months and years preparing to present and highlight their featured clinical trials and abstracts at ACR 2020.  This is our selection of their best studies for you to review and evaluate as part of your to-do list.

Article

Infection and Rheumatic Diseases: A New Dawn

Mrinalini Dey, MBBChir, MA(Hons) Cantab., MRCP, FHEA

Infection in the setting of autoimmune rheumatic disease (ARD) has been the subject of increasing research and clinical interest for decades. Despite the huge burden of infection in patients with ARDs, this area of research has really been catapulted to the centre-stage of research agendas and coverage at congresses, including ACR 2020, with the arrival of the coronavirus disease 2019 (COVID-19) pandemic.

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QD Clinic Podcast - 106 thru 109

Jack Cush, MD

Here is the last of our QD Clinics in Podcast form, just before we start ACR2020 coverage.



In this compilation from the past week we talk about



- HIV and arthritis



- Hyperuricemia in PsA



- An odd kind of dermatomyositis

David Liew Tweet
drdavidliew
DVT/PE has been the sticking point for baricitinib in RA. DVT/PE risk in integrated safety analysis >8y: incidence doesn't increase, but also doesn't decrease. No diff with dose either. Every drug has pros/cons; it's how we manage risk that counts... #ACR20 ABST0202 @RheumNow https://t.co/V88tQjcXSJ
Bella Mehta Tweet
bella_mehta
Data from the #ACR #RISE registry- 83,000 patients. Significant disparities in RA functional scores in Low SES, and got worse over time. ABS#0046 @RheumNow #ACR20 https://t.co/rcVb1gU250
Janet Pope Tweet
Janetbirdope
Vaccinate your pts against pneumococcal- it works! 595 vaccinated pts with RA & SpA vs 2379 nonvaccinated followed to 10 yrs showed 50% less pneumonia if vaccinated even though those pts had more infections prior. Limitation not RCT & not vaccine I use @RheumNow @CRASCRRheum https://t.co/SySEL19Gcn
Richard Conway Tweet
RichardPAConway
Dr Fernandez-Diaz on abatacept in RA-ILD in 263 patients. Abatacept appears safe and effective. Equivalent to RTX. Good option as s/c admin @rheumnow #ACR20 Abstr#0233 #ACRbest https://t.co/LfjqZpnGCh
David Liew Tweet
drdavidliew
When prescribing hydroxychloroquine for RA, SLE, or other rheumatic diseases, do you routinely order an EKG (either before or during)? #ACR20 @RheumNow
Richard Conway Tweet
RichardPAConway
Dr Choi et al case control study of methotrexate in RA. No increased risk of NAFLD seen. Increased trigs and BMI associated NAFLD @rheumnow #ACR20 Abstr#0181 https://t.co/WLPuf6Ga1D
sheila Tweet
RHEUMarampa
Using #MachineLearning, multimorbidity patterns predominant for #rheumatoid arthritis: cardiometabolic, cardiopulmonary & #Mentalhealth/pain disorders. Patterns similar to non-RA pts but prevalence higher in RA pts. @RheumNow #ACR20 abstr#0179 https://t.co/zfCxzKquDV
David Liew Tweet
drdavidliew
Even in early RA, there’s pain – and then there’s pain. Non-articular pain common very common in early RA (even at 12m) and a/w worse outcomes. Early RA isn't just about the inflammation: understand/treat the cause(s) of pain! from CATCH @earlyarthritis #ACR20 ABST0187 @RheumNow https://t.co/kR4waqHUnm
Meral K. El Ramahi, MD Tweet
MeralElRamahiMD
Do you plan to do a skin exam in your RA patients on MTX given new toxicity signal of skin cancer based on CIRT with NNH of 167? @JYazdanyMD #ACR20 Year in Review @RheumNow
Dr. John Cush Tweet
RheumNow
Eosinophilia in #RA is either due to a secondary problem (endemic parasitosis, drug hypersensitivity, etc) or may be associated with more severe RA - it is not associated with extraarticular manifestations of RA. https://t.co/J9rOA3cWC4
Dr. John Cush Tweet
RheumNow
Racial/ethnic minorities with rheumatic Dz(RD) & COVID had increased odds of hospitalization & ventilatory support. 1,324 pts w/ RD+COVID, 36% hospitalized, 6% died. Compared to whites- Blacks Latinos & Asians had higher risk of hospital (OR=2.7, 1.7, 2.7) https://t.co/OGmarAfzLM
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