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Extended-Release Fluticasone Propionate for Injectable Suspension - EP-104IAR
Phase 2 Randomized (1:1), Double-blind, Vehicle-Controlled Trial
318 pts, 57% F, age 64,
Clinically and statistically significant pain relief for 14 weeks compared to vehicle
@RheumNow #ACR23 #abstL04
Bella Mehta bella_mehta ( View Tweet)
Important data re:ADVOCATE study and health related quality of life
Interesting question: is this due to AVA or just simply giving less steroids?
I discuss this on recent podcast: https://t.co/7Jm6ArFpsB
@RheumNow #ACR23 https://t.co/53T1p2Vvyb
Mike Putman EBRheum ( View Tweet)
@EricFMorand SPOCS Study: A#2263 @ACR23
826 pts - 71% high IFN gene sig
Mean SLEDAI-2K lower with low IFNGS
6mo: pts reports 1+ flare 19% high IFNGS, 16% low. Both grps 6.7% LLDAS, but remission 4% low/1.7% high
In 36 mo, <10% LLDAS, <10% remission
@earlyARA @RheumNow https://t.co/z5v4TBVuDG
Eric Dein ( View Tweet)
Post hoc analysis of Ph2 AURA-LV & Ph3 AURORA1
⬆️VOC-treated pts achieved CRR at 1yr vs. control arm (41.0% vs. 21.9%; OR 2.48, p< 0.0001) and PRR at 1yr (OR 2.3, p< 0.0001)
Similar safety profiles
VOC: Additional tx option for LN pts w/ UPCR >/=2g/g
#ACR23 ABST2326 @RheumNow https://t.co/9z1n3s7umU
sheila ( View Tweet)
Very cool meta analysis of IL17i RCTs in PsA
No change in MACE in DMARD naieve pts initiating IL17i across RCTs
A skosh underpowered but worthwhile question & useful data
@RheumNow #ACR23 Abstr2254 https://t.co/ZN8QYgSA1A
Mike Putman EBRheum ( View Tweet)
A#2297 #ACR23 @RheumNow
Baseline IFNα predicts complete response at 2 yrs in LN
HIgh IFNα: incr risk of 2+ renal flare
Increase of 1 unit of IFNα incr risk of 2+ flares by 35% & risk of decr GFR
IFNα cutoff 0.6 for 2+ flare, 1.3 for progr to eGFR <15
AUC 0.6 (weak predictor) https://t.co/FKeDJVNyYj
Eric Dein ( View Tweet)
In this older grp of pts w/ chronic LBP, significant overlaps of deg & inflamm features on spinal imaging of DC, DISH & axSpA pts were seen
Also, +comorbids: HTN in DC; DM in DISH; smoking in axSpA
THM? DC & DISH are also axSpA mimics
#ACR23 ABST1862 @Rheumnow @rheumarhyme https://t.co/uNIwRchF1g
sheila ( View Tweet)
HCQ improves complements
A#2327 #ACR23 @RheumNow
Petri @jhrheumatology @andreafava
Pts w/ low complement & low HCQ levels
In pts who increased HCQ WB level >50 ng/mL, incr in mean C3 (p=0.02) v HCQ that did not incr
More nml C4 levels (p=.003) and incr mean C4 (p=.004) on HCQ https://t.co/J7PIuaRTO8
Eric Dein ( View Tweet)
HCQ Discontinuation
A#2343 #ACR23 @RheumNow
42 pts d/c HCQ
19% flared in past yr before d/c
D/c reasons: retina tox 57%, self-dc 17%, other eye issue 12%
26% flare in yr after d/c - strongest ass for flare: mean C3, dsDNA+ at index visit https://t.co/d4TqneS46u
Eric Dein ( View Tweet)
Another day, another bimekizumab (IL17i) study
Across 2 trials, improved PsA specific QOL ("PsAID") metrics
Nice to see focus on PROs & I always love a good spidergram
@RheumNow #ACR23 Absr2249 https://t.co/dsLXstPzt2
Mike Putman EBRheum ( View Tweet)
The patients’ voice matters! Watch my interview with @LAlupusLady regarding how she manages #Lupus and her perspective about the disease @rheumnow #ACR23 @uptoTate https://t.co/P9KPJQEkRv
TheDaoIndex KDAO2011 ( View Tweet)
All of us need to remind each other to take care of yourself!
Some tips from Dr. Whitney Marvin
- exercise, date night, talking to a friend
- take breaks, mindfulness
- eating away from computer (as I type this on my desk, next to my lunch)
@RheumNow #ACR23 https://t.co/UmmDqXRECN
Robert B Chao, MD ( View Tweet)
Will postpartum BME ⏩axSpA-like structural lesions?
Study by Varkas et al show there was no significant dev't of axSpA-like lesions on MRI in postpartum women 5 yrs after delivery.
Postpartum BME likely sec to transient mech stress-induced SI BME
#ACR23 ABST1892 @RheumNow https://t.co/KJ3DngmkbI
sheila ( View Tweet)
Always refreshing to hear from another specialist's point of view
Cardiologist @Bweber04 on CVD and rheumatologic diseases
Increased risk of death, MI and HF exacerbation in our pt population
Increased all cause mortality
@RheumNow #ACR23 https://t.co/yOkPOmxU4N
Robert B Chao, MD ( View Tweet)
@Bweber04 on recurrent pericarditis especially some seen in our lupus population
IL-1 inhibition with Rilonacept really redefining treatment success and altering the typical treatment algorithm
@RheumNow #ACR23 https://t.co/Ey1DN8eSXT
Robert B Chao, MD ( View Tweet)
Later today at #ACR23 at 4pm
See Ab#2545 on IV secukinumab for AxSpA
Read about it now on @RheumNow:
https://t.co/s9IinpVxgR
Eric Dein ( View Tweet)
RheumNow’s expanded coverage of #ACR23 annual meeting is sponsored in part by Novartis. All content is chosen by RheumNow & its faculty.
Dr. John Cush RheumNow ( View Tweet)
Watch: Ultrasound for PsA Stratification: Are We There Yet?
Dr. Aurelie Najm reports live from #ACR23
https://t.co/TnDVbKXcd4 https://t.co/RTbjL2wbUj
Dr. John Cush RheumNow ( View Tweet)
Interesting counterpoint to a tweet from a few days ago re:black box warning for JAKs
No change in utilization rates post black box... maybe people had already baked this into the cake by then?
@RheumNow #ACR23 Abstr 2142 https://t.co/K9cWbRSWV6
Mike Putman EBRheum ( View Tweet)
Amazing & thoughtful poster re:protocol violates in TICOSPA trial
51.2% of pts violated T2T protocol at least once... but did not impact primary outcome
Good baseline for future "strategy" style pragmatic trials
@RheumNow #ACR23 #ACRBest Abstr2201 https://t.co/FhctgFNdNP
Mike Putman EBRheum ( View Tweet)