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Pain in the Neck (7.28.2023)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. This week COVID persists, mortality from misdiagnosis, and cervical pain is more than a pain in the neck.

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IL-23 Inhibitor Performance in Psoriatic Disease

d Jack Cush, MD

IL-23 inhibitors are approved for the treatment of psoriasis and psoriatic arthritis; a single center real-world observational study shows three commercially available IL-23 inhibitors have high and similar drug survival and effectiveness in difficult-to-treat psoriasis and PsA.

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2023 ACR/EULAR Criteria for Calcium Pyrophosphate Deposition Disease

d Jack Cush, MD

The prevalence of radiographic chondrocalcinosis is estimated to be 4% to ≥10% in older adults, but the prevalence of symptomatic calcium pyrophosphate deposition (CPPD) disease is unknown. To advance our understanding of CPPD, the American College of Rheumatology and EULAR have published validated classification criteria for symptomatic CPPD disease.

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RNase Treatment of Autoimmune Disorders U1RNP complex, Ro/SSA and La/SSB are major RNA-containing autoantigens associated with autoimmune disorders. https://t.co/RuXV3uAVz7 https://t.co/rWaKlmPnEe

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Tofactitinib in PsA & RA: Nine Year Safety Data A real-world, post-marketing surveillance (PMS) of tofacitinib in PsA and RA shows a consistent pattern of safety with no new safety concerns identified. https://t.co/erBi7JJtCY https://t.co/9tU361FkfU

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Time to live your life. Do the right thing, make a difference, leave an imprint.. https://t.co/LEY7bFcV2S
Dr. John Cush RheumNow ( View Tweet)
Horizon announced its phase II RCT of Daxdilimab (anti-ILT7 mAB targeting dendritic cells) failed to meet its primary endpoint - BICLA response w/ pred ≤7.5 mg/day @wk48 (DAX=PBO). DAX also under study in alopecia areata, DLE, lupus nephritis https://t.co/8zDCWI5vB1 https://t.co/pVIg4ctvC5

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Unrecognized Mental Health Problems in Autoimmune Diseases More than half of patients with auto-immune conditions experience mental health conditions such as depression or anxiety, yet most are rarely asked in clinic about mental health symptoms. https://t.co/wxuGmuPh7D https://t.co/jMZkH1SIcS

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EULAR/ACR Guidance on HLH/MAS A EULAR/ACR task force has established evidence based, up-to-date guidance, and expert opinion on the evaluation, management and monitoring of patients with HLH and MAS. https://t.co/rZkxuaCsSf https://t.co/c0kHKmZbyt

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Rheumatoid vasculitis (RV) metanalysis: RV decreased sincefrom 9.1 (1988-2000) to 3.9 (2001-2010) per million. RV risk increased w/ smoking, disease duration, seropositivity, males, HLA-DRB104, HLA-C3. Common: skin (65–88%), CNS(35–63%), cardiac (33%) https://t.co/VADI7DbKSc https://t.co/UwJQmzpmkZ

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While COVID rates are near historic lows & far less dangerous, hospitalizations are up 10.3%, ER visits up 7%, pos. tests rose to 6.3% from 5.8% in the last week https://t.co/TFAt4p24au

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UK-NiCE Guidelines on Gout: Treat to Target to Prevent Irreparable Joint Damage Indications for Urate-lowering Rx: - Multiple/troublesome flares - CKD 3 to 5 - Diuretic Rx - Tophi - Chronic gouty arthritis https://t.co/eUqQpn7QUI https://t.co/eAGTRShYlf

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Dr. John Cush RheumNow ( View Tweet)
IL-1β inhibitors can be effective in #Gout. Based on metanalysis of 14 studies(10 RCTs), 4367 gout pts (Rx w/ anakinra, canakinumab rilonacept) Shows CAN, RIL better than active comparator at pain; CAN/RIL reduced gout flares https://t.co/57JSFtLLJD https://t.co/RueDE01jHj

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Link Between Vitamin D and Psoriasis Severity More than 8M people in the US experience psoriasis-a person’s vitamin D levels could play an important role in psoriasis severity, according to one of the largest studies to date. https://t.co/IMvFS0Vp4v https://t.co/cmQAIQ0U4p

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Dr. Joseph Flood (1952-2023) - Past ACR President Dr Joseph Flood, a past president of the American College of Rheumatology, passed away on July 13, 2023 at age 70 due to complications of liver disease, diabetes and liver cancer. https://t.co/G0elIbTsGg https://t.co/TaxCBxpOpo

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What is your effective treatment for rheumatoid Nodules?

Dr. John Cush RheumNow ( View Tweet)

Chronic neck pain is associated with increased mortality in individuals with osteoarthritis. NHANES study of 5965 adults, OA in 8.2% and 5.9% had neck pain. Neck pain assoc w/ 2 fold risk OA. OA pts w/ chr neck pain higher all-cause mortality risk (OR ~3) https://t.co/MLzJUa3AnY https://t.co/WB8lhvUOjw

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Dr. John Cush RheumNow ( View Tweet)
Ignaz Semmelweis (1818-65) a Hungarian physician whose work demonstrated that hand-washing could drastically reduce the number of women dying after childbirth. For this reason he is known as the ‘saviour of mothers’. #historyofmedicine #handwashing #obstetrics #antisepsis https://t.co/qt1kbPamXK
Past Medical History PastMedHistory ( View Tweet)
When you're the boss, "reasons don't matter...success or failure is totally within your control" - Steve Jobs https://t.co/5rDanu7Oj4
Dr. John Cush RheumNow ( View Tweet)
Estimated 795 000 Americans are misdiagnosed annually (371,000 pts die; 424,000 permanently disabled). Just 15 diseases account for about half of all serious harms & top 5 (Stroke, Sepsis, Pneumonia, VTE, Lung CA) account for 39% https://t.co/3pvgGLLHbs https://t.co/94ij9txIyK

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