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MMWR: Arthritis Among Children and Adolescents
The CDC estimates that nearly 220,000 children and adolescents had arthritis during 2017–2021.
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"Ask Cush Anything" Returns (7.21.2023)
Dr. Jack Cush reviews the news and journal reports and this week, takes on 5 cases/questions from "Ask Cush Anything"
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Voclosporin in SLE - Long-Term Safety and Efficacy
The AURORA 2 study evaluated the long-term safety and efficacy of VOC upus nephritis (LN) patients and, after 3 years, demonstrated long term safety and efficacy following the one-year AURORA 1 study.
https://t.co/uiqi8J9rrP https://t.co/3r6aAI3WTj
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"Ask Cush Anything" Returns
Dr. Jack Cush reviews the news and journal reports and this week, takes on 5 cases/questions from "Ask Cush Anything”
https://t.co/bjMuMPlCHK https://t.co/rmAwOsNSvq
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Study of 48 Jo-1+ anti synthetase pts shows Ab levels signif correlated w/ activity (r=0.4, p=.03) & CK (r=0.34, p=.002) & were signif higher w/ active disease (91.7 vs 44.4 IU/L). https://t.co/5TJYatLsEk Modest correl. prev seen https://t.co/tIsLCODKB6 https://t.co/rWA6M50ufV
Dr. John Cush RheumNow ( View Tweet)
Infectious Risk with B Cell Therapies in Lupus
A UK registry study of moderate to severe SLE showed that treatment with rituximab or belimumab was not associated with a greater risk of serious infection, when compared to standard of care therapy.
https://t.co/Dko5UQAl0G https://t.co/DQcrWtzQuY
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JAMA has a review of "Diagnosis and Treatment of Hip and Knee Osteoarthritis".
Affecting 240 million people worldwide, >32 million in the US. OA Risk factors include age, female, obesity, genetics, & trauma/injury. OA pts have more comorbidities https://t.co/fGgTLWj8Hc https://t.co/65hpkI8oo0
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Danger with Hydroxychloroquine Nonadherence in SLE
A large cohort study shows that severe non-adherence to hydroxychloroquine (HCQ) results in serious risks for SLE flares, damage, and mortality.
https://t.co/1trDJoTypb https://t.co/c7oPyxF8mC
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Don't bother just to be better than your contemporaries or predecessors. Try to be better than yourself. - William Faulkner (1897 - 1962)
Dr. John Cush RheumNow ( View Tweet)
SLE and Pregnancy Outcomes
Obstetric complications and poor pregnancy outcomes are not uncommon in women with systemic lupus erythematosus (SLE), especially with active disease.
https://t.co/ojFccY6kTT https://t.co/kJpIZP1kSd
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EULAR Points to Consider in Progressing Psoriasis to Psoriatic Arthritis
The transition from psoriasis to PsA – and the early diagnosis of PsA – is of considerable scientific and clinical interest.
https://t.co/OxcpnJ5EOe https://t.co/ggOnwt3wck
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Plantar Fasciitis study of 180 PF patients shows no clinically meaningful difference between pts treated with patient advice plus heel cup alone (PA) versus PA and lower limb exercise (PAX) versus PAX plus corticosteroid injection (PAXI) https://t.co/hkDuCOYICy https://t.co/ZGicUqXN8l
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Combination Cannabidiol (CBD) & hydroxychloroquine in RA? A phase II trial of IHL-675A (CBD+HCQ) will soon begin; following on phase I and animal studies showing it was tolerated, with no adverse events of concern.IHL-675A was superior to HCQ alone. https://t.co/H90D9LzNSo https://t.co/JiS6HL38Jg
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RNase Treatment of Autoimmune Disorders
U1RNP complex, Ro/SSA and La/SSB are major RNA-containing autoantigens associated with autoimmune disorders.
https://t.co/4Q8NGgKvfj https://t.co/QavCtY1E83
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Have a rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology.
https://t.co/vGt12ul6iy https://t.co/044BScmSYc
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US claims data shows the incidence rate of Herpes zoster (HZ) to be higher in RA (21.5/1000PY;HR 1.93) than non-RA (7.6/1000PY), increasing with age in RA,≥ 65 yrs -23.4/1000PY), highest w/ steroids and JAK inhibitors https://t.co/yH5bRGEyFh https://t.co/avvHwPkvJB
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Bringing pivotal clinical trials to you: announcing RheumNow’s Poster Hall, featuring previously presented, sponsor-generated clinical trial posters designed to educate and inform.
https://t.co/dHg0rrKcQ8 https://t.co/qtUxGg3waX
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Infectious Risk with B Cell Therapies in Lupus
A UK registry study of moderate to severe SLE showed that treatment with rituximab or belimumab was not associated with a greater risk of serious infection, when compared to standard of care therapy.
https://t.co/AbqrlU3qpw https://t.co/RlyWaTjWO1
Links:
Dr. John Cush RheumNow ( View Tweet)
Words of wisdom from Dr. Bharat Kumar, editor of the Rheumatologist @BharatKumarMD https://t.co/VbgI9ew5T8
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Cohort comparison of Psoriatic arthritis in 141 males vs 131 females: found psoriasis (BMI , BSA) was worse in males, but PsA worse in females (higher PtGA, PtPnV, TJC, SJC, DAPSA, HAQ-DI, and PsAID-12). Men more likely to get to MDA than females https://t.co/e1mFo0kCtL https://t.co/LfJJZc5Ecp
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Dr. John Cush RheumNow ( View Tweet)