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How Often Do You Monitor MTX? (6.16.2023)
Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com, including new drug approval, a new SpA variant and new rules for methotrexate (MTX) monitoring and depression screening.
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ACR Concerned with MedPAC’s Cutting Part B Reimbursement
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ACR
The American College of Rheumatology (ACR) today expressed disappointment that the Medicare Payment Advisory Commission (MedPAC) has recommended yet another cut to physician reimbursement for infusing life-altering treatments as part of its June 2023 Report to the Congress: Medicare and the Healt
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WATCH: Update on CAR T-Cell Therapy in SLE & Autoimmune Diseases
Dr. Peter Nash reporting from EULAR 2023 in Milan, Italy.
https://t.co/EpsPtwtJJt https://t.co/QxH8Pff6RS
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275 early RA pts and after 2 years, 32% reported unacceptable pain (UP). Predictors of UP best seen at 3 mos FUV (not baseline) and included #Tender Jts (not swollen), overall pain, patient global assessment, and HAQ. https://t.co/Zlv3919Ucz https://t.co/1K1zPvhUYi
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EULAR Offers Tips on Psoriasis Progression to PsA
Clinicians treating patients with psoriasis should be on the lookout for certain signs that joint involvement is likely to develop, according to a new "points to consider" from the EULAR.
https://t.co/eFsWJBmzCR https://t.co/slq58tWJG6
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Biosimilars Match Biologic Originators in RA
A JAMA review shows that biosimilars of adalimumab, infliximab, and etanercept were associated w/clinically equivalent treatment effects compared with their ref biologics for treatment of RA.
https://t.co/EO22ThFL5C https://t.co/wlK0e2Cg5l
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BIOSIMILARS (93 in EU, 40 in US) are approaching a tipping point with 8 new adalimumab biosimilars in 2023. Humira sales are down ~26% in 2023. Biosimilar sales expected - $129 billion in next 5 yrs, with estimated savings of $181 billion https://t.co/HMOYaSaIBQ https://t.co/6jOujr4JXQ
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Dr. John Cush RheumNow ( View Tweet)
Time to Risk Stratify Methotrexate Lab Monitoring?
A longitudinal cohort analysis has developed a prognostic model that informs a risk stratified approach to monitoring blood tests during long term methotrexate (MTX) therapy.
https://t.co/AP89MAIlJM https://t.co/YpfWFCLF1z
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Should we be reassured of JAK safety with new data?
Dr. Janet Pope discusses abstracts OP0133 and OP0132 at EULAR 2023 in Milan, Italy.
https://t.co/gxLJGHXwlm https://t.co/SgdGRJXBIi
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Bimekizumab (Bimzelx) has been EMA approved to treat adults with active PsA & axial spondylarthritis in the EU. This dual IL-17 A/F inhibitor is approved to treat moderate -severe plaque psoriasis in the EU, Canada, UK & Japan; but not yet in USA https://t.co/DGczkgHtpZ https://t.co/TquFCuh4QG
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Swedish registry study shows of 3629 children born to mothers with RA#, 70 (1.94%) were diagnosed with Autism Spectrum disorder (ASD). If RA was dx before delivery, an increased risk of ASD (HR = 1.43), especially for seronegative RA (HR = 1.61) https://t.co/fA6gzta5rx https://t.co/mGdzTqjEr7
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RheumNow’s newly launched Poster Hall features sponsor-generated clinical trial posters designed to educate and inform. Check out our Poster Hall today!
https://t.co/opulSMICUf https://t.co/XtWePsWQCt
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Assessment of Psoriatic Arthritis: A Global Perspective
Drs. Antoni Chan, Nelly Ziade and Ihsane Hmamouchi discuss POS1542 presented at EULAR 2023 in Milan, Italy.
https://t.co/qkhdNDn37k https://t.co/Ux4PCxRdn8
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Dazodalibep: A Glimmer of Hope is Sjogren's Syndrome?
Dr. Yuz Yusof reports on abstracts OP0143 and LB0003 presented at EULAR 2023 in Milan, Italy.
https://t.co/TPcdJ2rIsP https://t.co/5WZizA0TU8
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What to do with all this JAKi safety real world data?
Dr. David Liew reporting from EULAR 2023 in Milan, Italy.
https://t.co/AgDBOxAUx6 https://t.co/iRZuT0g7vq
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Dr. John Cush RheumNow ( View Tweet)
Why Depression Screening Should be Mandatory at Each Visit
Depression is more widespread than ever in the US, according to a new study from Gallup, showing that 18% of adults are depressed– an increase in 7 percentage points since 2015.
https://t.co/2u82MXIFvb https://t.co/ZpGi4TYdBL
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High Mortality Rates with Depression in Rheumatoid Arthritis
A Danish cohort study has shown a deadly association between depression and rheumatoid arthritis (RA).
https://t.co/R2MB4bs0Hr https://t.co/rWIfHmBqr8
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Excessive alcohol intake associated with higher risks of 61 diseases in men, including liver cirrhosis, stroke, and several gastrointestinal cancers, gout, cataracts, some fractures, and gastric ulcer. https://t.co/WqMuHQ3Unn https://t.co/IU0SaRcswZ
Dr. John Cush RheumNow ( View Tweet)
519 pts in the Hand OSTeoArthritis in Secondary care (HOSTAS) cohort studied & 17% had prolonged morning stiffness (>60 min); mild in 30%, intermediate in 37%, severe in 18% and extreme in 4%. Assoc w/ more pain, worse function and QOL https://t.co/6LSir7nSae https://t.co/lhoxwpfuqD
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Study of 162axSpA pts found that 46.6% reported abnormal sleep behavior, worse in Female patients vs males (P <.001). Such pts were more likely to have depression (P = .015) and worse health-related QoL (HRQOL) (P = .015) https://t.co/a1OoUTPKiV https://t.co/gkjkkdljOh
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Dr. John Cush RheumNow ( View Tweet)