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From Fitbit to first diagnosis: AI is rewriting the RA playbook
Artificial intelligence isn’t a distant frontier anymore. It’s here, and it appears able to detect signs of rheumatoid arthritis, possibly before we can clinically detect it. Two studies presented at this year’s ACR meeting highlight just how close we may be to a future where algorithms flag disease before we can and monitor activity with minimal patient burden.
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New Insights into Pregnancy Outcomes and Maternal-Fetal Health in Rheumatic Diseases
ACR Press Release
At ACR Convergence 2025, the American College of Rheumatology presents new research illuminating critical challenges and advances in pregnancy outcomes for women living with rheumatic diseases, including axial spondyloarthritis, antiphospholipid syndrome, and lupus.
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Sleep Apnea in Psoriatic Arthritis – A Wake Up Call
Fatigue is one of the most disabling symptoms in psoriatic arthritis (PsA), yet its causes are often underexplored. At ACR 2025, Abstract #0549, a possible hidden contributor was studied: obstructive sleep apnea (OSA).
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Mimics of ANCA-associated vasculitis: How can we tell?
With increased disease awareness and more regular, accessible testing for anti-neutrophil cytoplasmic antibodies (ANCA), ANCA-associated vasculitis (AAV) has become an increasingly recognized clinical entity in rheumatologic practice.
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SLE & arthritis: Is there a difference?
Abstract #0629:
- Non-deforming (ND): 73% | Jaccoud’s: 19% | Rhupus: 8%
- Vs ND, Rhupus had lower odds of type I IFN signature
- Time to deformities: Jaccoud's ~2 yrs vs Rhupus ~5 yrs
- RNP+ predictive of Jaccoud’s
@RheumNow #ACR25
Akhil Sood MD, MS AkhilSoodMD ( View Tweet)
Managing lupus is complex. How do we ensure quality care?
Abstract #0218 convened 8 focus groups:
✅ Support for patient navigators
⚠️ Barriers: low resources, staff turnover
💻 Solution: EHR outreach workflow to flag missed visits & labs
@RheumNow #ACR25 https://t.co/BWaIMMEPit
Akhil Sood MD, MS AkhilSoodMD ( View Tweet)
DESIR cohort of early axSpA:
✳️Factors assoc w/ D2M axSpA - female sex, ⬆️ASDAS-CRP ⬆️BASFI ⬆️ASQOL at baseline.
✳️ Low prevalence of pts meeting D2M definition (15 pts - 8.4% bDMARD-treated)
#ACR25 @RheumNow Abs0544 https://t.co/fBUh3myKcz
sheila RHEUMarampa ( View Tweet)
Abstract #0189: Rheumatologists are early adopters and high utilizers of #AI scribes.
📊 Adoption: 41%
🧑💻 Retention: 100%
💬 High utilizers (> 70% visits): 83%. The highest among IM subspecialties
🕒 AI scribes reduced EHR time across all measures.
@RheumNow #ACR25 https://t.co/TBurWUKhMl
Akhil Sood MD, MS AkhilSoodMD ( View Tweet)
In a nationally representative NHANES sample, inflammatory back pain (IBP) was not associated with HLA-B27 positivity or elevated CRP, regardless of IBP criteria used (e.g., Berlin 8a: OR 0.88, p=0.876). IBP alone may be insufficient for identifying axSpA-related immunogenetic or https://t.co/82NjVU171z
Antoni Chan MD (Prof) synovialjoints ( View Tweet)
Getting down with Jack at the @RheumNow #ACR25 stand - come and say hello!
(and Ask Cush Anything - scan the QR code, and maybe end up on the podcast!) https://t.co/0u0boHIIR3
David Liew drdavidliew ( View Tweet)
Come to our first #HealthLiteracy poster of #ACR25!
#0190
Cluster analysis >900 people with IA
Lowest health literacy cluster assoc w:
4× ⬆️anxiety/depression
2× ⬆️disease activity, vs highest HL
Higher HL assoc w older age & ⬆️comorbidities but fewer mental health Sx
@RheumNow https://t.co/iIRXaOl4qZ
Links:
Mrinalini Dey DrMiniDey ( View Tweet)
#0773 Anti-MDA5 epitope mapping identifies key regions (aa 201-300, 601-700) linked to treatment resistance & poor prognosis in DM-ILD and even IIPs.
Epitope-specific antibodies could refine risk stratification & guide therapy in ILD beyond autoimmune disease. @RheumNow #ACR25 https://t.co/moRffVGZPn
Mrinalini Dey DrMiniDey ( View Tweet)
#LLM can be #virtual #tutor for
👇
#OSCE
RCT - better competence &confidence
#AI & #medical #education
AI trained to #tutor
Also grading OSCE #AI + human
@RheumNow @ACRheum #26S17 https://t.co/CzKoxyjpY8
Janet Pope Janetbirdope ( View Tweet)
#Pros and #cons of #AI
Need to know both
Need to assess AI #quality and #accuracy
‘Assume AI WILL be used’
JHausmann
By trainees, patients and medical personnel
Train #faculty re #AI
#ACR25 @RheumNow @ACRheum
#26S17 https://t.co/CvPDQPbueW
Janet Pope Janetbirdope ( View Tweet)
Topical therapies in cutaneous lupus - find the right level
Victoria Werth #ACR25 SLE guideline session @RheumNow https://t.co/o3gBuFkr4n
Links:
David Liew drdavidliew ( View Tweet)
High-resolution ultrasound detected subclinical enthesitis in 44% of psoriasis patients without arthritis and 12% had PD positivity. Supports a preclinical PsA phase and use of MSUS to detect entheseal inflammation in both symptomatic and asymptomatic PsO patients for timely
Antoni Chan MD (Prof) synovialjoints ( View Tweet)
Don’t fight #AI
#RCTs - #AI better at soft
Skills alone
Vs
#Medical input and AI as we tend to
Disbelieve the model & mess it up!
#LLM can accurately take a #history
Bottom line EMBRACE AI ?check it too
#ACR25 @RheumNow @ACRheum
#artificial #intelligence and #medicine
26217 https://t.co/22MYD4QqzH
Links:
Janet Pope Janetbirdope ( View Tweet)
Wondering whether rheumatology is the specialty for you?
Dr Bryant England kicks off the clinical science #YearInReview with an impressive overview of what a year in rheumatology looks like.
New drugs, new devices, new disease names! 🤯
#ChooseRheumatology
#ACR25 @RheumNow https://t.co/uLrNFPgeAn
Mrinalini Dey DrMiniDey ( View Tweet)
#Sjogren disease is here to stay.
“The name has caught up to the science of SD and this can translate to better treatment outcomes for patients” - Dr. Bryant England
#ACR25 @RheumNow https://t.co/M4r0XXkswv
sheila RHEUMarampa ( View Tweet)
Basic Sci Year in Review:
Dr. Anne Davidson discusses the potential pathologic link bet tryptophan, indole, I3S & IL-17 pathways.
I3S induces epidermal thickening in mice and correlated with dse activity in patients with #psoriasis
#ACR25 @RheumNow https://t.co/WNNbBBESQ3
sheila RHEUMarampa ( View Tweet)
