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pregnancy,birth,preterm,baby

Antenatal Corticosteroids and Serious Infection in Offspring

d Jack Cush, MD

A claims data study shows that maternal use of antenatal corticosteroids may be associated with an increased risk of serious infection in the offspring's first 12 months. 

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Best,5star,rate,rank

2023-2024 Best Rheumatology Hospitals

d Jack Cush, MD

Johns Hopkins Hospital in Baltimore has been named the top hospital for rheumatology by U.S. News & World Report. This is the 6th year in a row they have held this spot.

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Bifunctional B-cell Targeted Therapy in IgG4-related Disease

d Jack Cush, MD

A novel B-cell depletion trial, using obexelimab (a bifunctional, monoclonal antibody that binds CD19 and Fc gamma receptor IIb), has shown efficacy and safety in patients with active IgG4-related disease.

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Tofacitinib in Polymyalgia Rheumatica (EAST PMR Study)

d Jack Cush, MD

An open-label, uncontrolled pilot trial has shown that JAK signaling is involved in the pathogenesis of PMR and that tofacitinib is as effective as glucocorticoids (GC) in patients with polymyalgia rheumatica (PMR).

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microbe,bacteria,blue

Altered Gut Biome in Inflammatory Arthritis

d MedPage Today

Another study has confirmed that the intestinal microbiome's composition in people with inflammatory arthritis differs from that in other people, and in potentially unhealthy ways -- but whether the microbiome alterations actually cause arthritis is less clear.  In fact, the investigato

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Predicting Inflammatory Arthritis in At-Risk Persons

d Jack Cush, MD

The Annals of Internal Medicine has published a predictive score to distinguish low-risk from high-risk inflammatory arthritis (IA) and who may benefit from risk stratification and preventive measures.

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Spinal CT study of 40 ankylosing spondylitis pts shows the most common site and region of intervertebral fusion were the posterior vertebrae of the middle thoracic region >50% halffused posterior vertebrae Th4–Th5 to Th7–Th8, followed by Cx, last lumbar https://t.co/Zxchr4yUGI https://t.co/QD554Yo7cV

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Vegetarians have a significantly higher hip fracture risk (HR 1.50) than regular meat-eaters, partly (28%)explained by BMI. UK Biobank compared meat-eaters (n=regular 258,765, occasional 137,954), pescatarians (9557), & vegetarians (7638) https://t.co/EyL1PPpfYE https://t.co/n0wNDVWMuP

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Predicting Inflammatory Arthritis in At-Risk Persons The Annals of Internal Medicine has published a predictive score to distinguish low-risk from high-risk IA and who may benefit from risk stratification and preventive measures. https://t.co/I5sLbkvNdT https://t.co/YpOiDYiajW

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Hong Kong study shows Very low dose prednisolone (<5 mg/d) doesn't confer excessive CV risk. 2 233 RA pts (105 826 Pt-years FUV; mean duration 8.7 yrs) - 7% developed MACE. MACE risk incr 7% per month in those taking ≥5 mg pred. https://t.co/lcehOgaqCQ https://t.co/AhWGnUuYcc

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High mortality risk predictors in patients with anti-MDA5 dermatomyositis include: - rapidly progressive interstitial lung disease - anti-Ro52 antibody - age > 57 years (based on study of 126 MDA-5+ DM pts) https://t.co/VCyLhStFgX https://t.co/y3CyzOlwDt

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Spanish study of 518 #SLE patients, 7% of whom received at least one dose of rituximab(26) or belimumab (11). RTX given for either hemolytic anemia or ITP (11 pts), nephritis & CNS SLE (5 pts ea). BEL mostlyfor arthritis (8 pts) https://t.co/IqCVfOL5rb https://t.co/ocLj7Ejs7A

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Study of Veterans, Medicare, Medicaid RA pts (73070) pts, matched 1:10 w/ non-RA (639268) looked ataortic valve risk; RA pts have incr risk incident AS (adj HR 1.48), aortic valve surgery (aHR 1.34) & AS-related death (aHR 1.26). AS incidence=3.97/1000PYs https://t.co/rvA59hn6FE https://t.co/IS9jjuhYWv

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Synovial T cells from 20 pts Rx w/ immune checkpoint inhibitors who developed ICI-arthritis compared w/ synovial T cells from RA & PsA pts - showing clonal expansion of activated effector CD38hi,CD127−, CD8 T cells, w/ incr type I IFN-assoc transcripts https://t.co/vw2sOGL6jQ https://t.co/uDlt9dH4mQ

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Metabolic Burden in the Early Stages of PsA Dr. Aurelie Najm discusses abstract OP0066 presented at EULAR 2023 in Milan, Italy. https://t.co/08qOjVJE9A https://t.co/eH6oWsB1dT

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The Importance of Knowing Which Entheses are Involved in PsA Dr. Eric Ruderman discusses abstract POS0027 presented at EULAR 2023 in Milan, Italy. https://t.co/nRJfNxwDF0 https://t.co/LUgLQTIUDD

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New Full Length from A&R: A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial of Obexelimab in Systemic Lupus Erythematosus with Exploration of Response Based on Gene Pathway Co-Expression Patterns https://t.co/5pzBfiZaNt Created with https://t.co/L5O6lHuNSY https://t.co/HvDy4b1Bg3

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Retrospective study of 1877 pts. W/ granulomatosis with polyangiitis (GPA) on RTX found only 23% received TMP-SMX for a median of 141 days. Prophylaxis was assoc w/ prednisone use (OR 3.96), MTX use (OR 1.48), ICU care (OR 1.95), hospitalization(OR 1.56) https://t.co/JRUC8HUwJU

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Pain in the Neck https://t.co/JxNBJvlekM https://t.co/vaPSDK2vHQ

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IL-23 Inhibitor Performance in Psoriatic Disease A single center real-world observational study shows three commercially available IL-23 inhibitors have high and similar drug survival and effectiveness in difficult-to-treat psoriasis and PsA. https://t.co/J3HIDBguj1 https://t.co/uqYf0Bdh0n

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