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Painter Peter Paul Rubens had Rheumatoid Arthritis as demonstrated in swellings and deformities observed in this self-portrait
An image I often use in my teaching to student of clinical aspects of RA
#rheumatologyandart #teachingpearls
#EULAR23 @RheumNow https://t.co/xwDisTUHdy
Aurelie Najm AurelieRheumo ( View Tweet)
#EULAR2023 #POS1124 My newly diagnosed patients & their carers often expressed heightened anxiety with poor quality web info about #SLE. Thank you @LupusEurope for this wonderful effort 👏. Available in most European languages too @RheumNow https://t.co/cr5Ls117xM
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Study on folylPG synthétase (FPGS) activity and MTX-PG measured in sperm showed low bio active form of MTX-PG, low FPGS activity resulting in lower capacity to form MTX-PG, Perez-Garcia LF, Abst#OP0224 #EULAR2023 @RheumNow https://t.co/8sGQOBxn8r
Dr. Antoni Chan synovialjoints ( View Tweet)
A shame. Pts with #scleroderma are dying waiting for organ transplant- we should list and work them up for Tx earlier. PAH Pts May do worse @eular_org #EULAR2023 @RheumNow OP0241 https://t.co/8ZlHJmETGA
Janet Pope Janetbirdope ( View Tweet)
Herpes Zoster vaccination in RA patients treated with Upadacitinib and MTX showed a satisfactory response,
slight reduction in response compared to general population in both antibody and cell mediated responses Winthrop K, Abst#OP0225 #EULAR2023 @RheumNow https://t.co/wxwbOYsn5K
Dr. Antoni Chan synovialjoints ( View Tweet)
#EULAR2023 #POS0222 Post-hoc Analyses of Phase 3 RCT in Rituximab-treated ANCA vasculitis patients only (65% of total) showed more patients met Remission rate & with lower GC Toxicity vs Pred Taper + RTX at 52 weeks, consistent with Trial Main Results @RheumNow https://t.co/BmiujbhQI9
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Let le introduce you to ARTHUR 🤖
A very skilled robot who scans your hands and wrists in 15 mn 🤚
Amazing to see new #AI developments that will make our lifes’ easier!
#EULAR23 @ROPCA3 @JustSoren Stand M6
@RheumNow https://t.co/7PtR2CGqTt
Aurelie Najm AurelieRheumo ( View Tweet)
So what kind of changes do we see in ACPA+ arthralgia patients, in the 6 months prior to them developing inflamm arthritis?
- ACPA titre up, RF pos
- EMS, pain up
- ESR up
Good things to keep an eye on in pre-RA
Emery group POS1046 #EULAR2023 @RheumNow https://t.co/cSKPb5SbVH
David Liew drdavidliew ( View Tweet)
‘Where have all the rheumatoid nodules gone?’
(Fantastic poster title @MayoClinic)
Don’t get to see them much in clinic anymore. Almost surprised when I do
Smoking is down
Therapies are better
RA is changing
(a fact worth remembering!)
POS1066 #EULAR2023 @RheumNow https://t.co/VxDNusIjOa
David Liew drdavidliew ( View Tweet)
#EULAR2023 #POS1069 SLR & meta-analysis to inform EULAR Points to Consider which included 15 studies showed that targeted therapies were not associated with increased risk of cancer recurrence in patients with inflammatory arthritis AND a historyof cancer (85% had RA) @RheumNow https://t.co/uK2XHLjpj8
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
‘Clinically suspect arthralgias: fact or myth’ - a great debate topic #EULAR2023
First, the argument for. And we start with a reminder as to what we really mean by CSA
@RheumNow https://t.co/e1CdxKi69m
David Liew drdavidliew ( View Tweet)
“There was a time when a well-rounded physician had a good grounding in the humanities as well, and we lost that as more teaching time focused on understanding medical science and technology.” Brian Goldman
@RheumNow https://t.co/tfXHPRJXAo
Aurelie Najm AurelieRheumo ( View Tweet)
To treat or not? Clinically suspect arthralgia does affect QoL including function. Both premises of treating with a DMARD are valid. OverRx v missing the very early window of opportunity @RheumNow #EULAR2023 @eular_org https://t.co/86CVZ2IjEf
Janet Pope Janetbirdope ( View Tweet)
Use of antîmalarials in RA reduced the risk of bacterial infection in RA, smaller number of viral and fungal to study impact on systematic infections Bredemeier M, Abst#OP223 #EULAR2023 @RheumNow https://t.co/RXuFi3LdZC
Dr. Antoni Chan synovialjoints ( View Tweet)
Should we use #immunesuppression EARLY in #scleroderma to prevent #ILD? Answer from a study comparing Y vs N immune suppression- there was no difference in FVC decline. Maybe not a long enough study, ? Chanelling bias scleroderma #lung #disease OP0239 @RheumNow #EULAR2023
Janet Pope Janetbirdope ( View Tweet)
#EULAR2023 #POS1128 Promising new therapy on the block for #lupus nephritis. A single arm Phase 2a study showed Zetomipozomib, selective immunoproteosome-i + MMF showed about 2/3 pts met =>50% reduction in uPCR at WK24. No safety signal including low IgG or infection @RheumNow https://t.co/0A8cCW5GVV
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
50% reduction of RF levels
& Complete seroconversion at M3 predicts LDA and Remission at M6 to M24 period after treatment initiation.
RF responders reach LDA/Rem faster.
Exciting data but... SDAI remains the stronger predictor of response at M3
@Rheumnow #EULAR23 OP0272 https://t.co/td1MZEzqag
Aurelie Najm AurelieRheumo ( View Tweet)
We worried that JAKi + MTX might impair Shingrix efficacy, esp given JAKi HZ risk
Shingrix nested in upa RCT:
Response (seroconversion rate, titres, cellular response) less than gen pop, but still very good
+ only 2/95 had RA flares
Vaccinate away!
OP0225 #EULAR2023 @RheumNow https://t.co/i4ObRSyYh9
David Liew drdavidliew ( View Tweet)
#ClinicalPearl Rx of #scleroderma #ILD -add another drug. MMF, then Cyclo, Rituximab, ?tocilizumab; if progressive fibrosis then #Nintedanib ?Pirfenidone Small RCT of MMF v Tacrolimus - looked the same -helpful if MMF fails, future pregnancy OP0240 @RheumNow #EULAR2023 @eular_org https://t.co/XWphyEO2JJ
Janet Pope Janetbirdope ( View Tweet)
Natural sequence of events happening in a subclinically inflamed joint, serial MRI study
When progressing to clinical RA
First osteitis then synovitis & tenosynovitis
🦴➡️✋
During resolution tenosynovitis reduces first then synovitis & osteitis
@RheumNow #EULAR23 OP0261 https://t.co/ic94htYv6T
Aurelie Najm AurelieRheumo ( View Tweet)