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2010 Colchicine Price Hikes Adversely Affected Gout Care

d Jack Cush, MD

Researchers from Harvard have reported their analysis showing that the large increase in colchicine cost in 2010 was associated with an immediate decrease in colchicine prescription use, with a 10 year increase in emergency department and rheumatology gout visits suggesting poorer gout control.

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B-Cell Stimulating Factors Tied to Lymphoma in Sjogren's

d MedPage Today

Genetic blood tests indicated that Bruton's tyrosine kinase (BTK) and a cytokine called APRIL were overexpressed in patients with primary Sjögren's syndrome who subsequently developed lymphoma, French researchers reported, suggesting that BTK inhibitors might be useful in this population.

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ICYMI: Psoriatic Arthritis and Pregnancy

d Eric Dein, MD

Dr. Christina Chambers, an epidemiologist at the University of California San Diego and the principal investigator of MotherToBaby Pregnancy Studies, reviewed the available data on psoriatic arthritis and pregnancy. There is little evidence at this time that pregnancy affects PsA, though studies reliably demonstrate increase in disease activity in the post-partum period in both skin and joint disease.

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Study of 481 incident RA: - no risk of RA w/ tea, alcohol & sugar-soft drinks - Incr RA risk seen w/ coffee [≥4 vs ≤1cup, HR=1.24;p=0.04] & diet drinks [HR=1.66;never-smokers] - Reduced RA risk w/ mod EtOH (ever-smokers;HR=0.63) & wine (seropos RA) https://t.co/gPZkTl9rid https://t.co/khYEZYFotl

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Dr. John Cush RheumNow ( View Tweet)
Tuesday Night Rheumatology: POD 3: Vasculitis: Evolution and Advances This webinar will feature highlights from these lectures followed by live audience Q & A: -New Therapies for PMR & GCA -Assessment of GCA and PMR -GPA Treatment Choices https://t.co/MQBAEmUvuC https://t.co/qh2By6a3Kf

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Dr. John Cush RheumNow ( View Tweet)
JAMA: n 2020, 42 114 deaths in the US were related to falls, with 86% occurring among adults aged >65 years. Falls are a leading cause of injury and leading causes of death among older adults in the US - And these #s are increasing betw '99 & 2020 https://t.co/3sXSCXZ8Q6 https://t.co/PSi3xcT8fJ

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Dr. John Cush RheumNow ( View Tweet)
In 2020 Filgotinib (Jyseleca) did not seek FDA approval over FDA concerns & pending RCTs on safety & spermatogenesis. Now the results (MANTA & MANTA-RAy) are published showing FIL has no effect on semen & sex hormones. But still no filgotinib in USA https://t.co/4IHoOpylXm https://t.co/VPqW5Ktcc4

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Psoriatic Arthritis and Pregnancy Christina Chambers, PhD, MPH delivered a standout lecture on psoriatic arthritis and pregnancy on Saturday, the first day of RheumNow Live 2023. Check out the summary from Dr Eric Dein ( @ericdeinmd ) https://t.co/Lo8FpewC4V https://t.co/ntp47kwKbK

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Dr. John Cush RheumNow ( View Tweet)
One in Ten has Autoimmune Disease A UK population-based study suggests that autoimmune diseases affect approximately one in ten individuals. https://t.co/WpsnDGiNHt https://t.co/llGcOFQMmx

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Dr. John Cush RheumNow ( View Tweet)
Watch: Insights into the Future of Osteoarthritis RheumNow Live 2023: Philip Conaghan, MBBS, PhD, University of Leeds, Biomedical Research Centre https://t.co/xjccnULOBn https://t.co/inIDFDN7GA

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Dr. John Cush RheumNow ( View Tweet)
RNL23 Replays (5.6.2023) This week on the podcast we feature replay content from RNL 2023, cannabis effects on pain and sleep, and what drives PJP risk the most - steroids or RTX? https://t.co/hmJQBq3krb https://t.co/xeh0gOqoTf

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Dr. John Cush RheumNow ( View Tweet)
Downs Syndrome (1/700) & autoimmune mechanisms - Downs has a 4-6 fold higher risk of JIA, type 1 diabetes, autoimmune thyroid disease and coeliac disease. https://t.co/wVUDRCS96I https://t.co/RosPAkRnPA

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Dr. John Cush RheumNow ( View Tweet)
Thanks to these Rheumatology Influencers who were tweeting & teaching from RheumNow Live 2023! Look for all the RNL23 Replays this month- videos, podcasts, articles, & tweets @ericdeinmd @doctorRBC @NoufAhmedAlham2 @Janetbirdope @uptoTate @anisha_dua @DrLauraCoates https://t.co/AgvQ06dp3Z
Dr. John Cush RheumNow ( View Tweet)
in 2022 COVID slid from the #3 to the #4 cause of death in USA, accounting for nearly a quarter million deaths, a 47 percent decrease from the 462,193 Covid-related deaths in 2021. Most COVID deaths occured in the first few mos of 2022 https://t.co/qervCp0P87 https://t.co/WN7DvsFhNC

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Dr. John Cush RheumNow ( View Tweet)
Does King Charles have Sausage Digits (dactylitis) or OA? https://t.co/mRis21OWKH https://t.co/mRis21OWKH https://t.co/TmPDKu6ARh

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Dr. John Cush RheumNow ( View Tweet)
Prevalence and Mortality of IgG4-related disease in the USA A review of the epidemiology of IgG4-RD in the USA shows a low prevalence with possibly increasing numbers, owing to increasing awareness of this unique immune-mediated condition. https://t.co/umWCPX4ing https://t.co/ZIButYrtp0

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Dr. John Cush RheumNow ( View Tweet)
Romosuzumab and Low Sclerostin Levels Underlie CV Risk New research highlights potential safety concerns around women taking romosozumab, a new anti-osteoporosis drug available on the NHS. https://t.co/tRGOXrm0Fk https://t.co/ebiRpCC81p

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Dr. John Cush RheumNow ( View Tweet)
Contratulations to Dr Germain Honvo (Univ. of Abomey-Calavi, Univ. Liège/Belgium) in receiving the 2023 Pierre Meunier Young Scientist Award from ESCEO & the International Osteoporosis Foundation (IOF) for his work in osteoarthritis, aging & locomotion https://t.co/gOB6VfP9vn https://t.co/SBbexkty4F

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Dr. John Cush RheumNow ( View Tweet)
Clinical overview of subacromial pain syndr (SAPS) Brit J Sports Med. SAPS has heterogeneous causes; Dx by physical examination and imaging. Need to exclude glenohumeral OA, frozen shoulder, GH instability, rotator cuff tears, neuro & cervical disorders https://t.co/d77kXa2qSi https://t.co/vBF0692huh

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Dr. John Cush RheumNow ( View Tweet)
DDW 2023 study claims microscopic colitis (MC) pts had a 2fold higher risk of #RA. 11,293 MC pts matched 1:5 w/ population controls. With 8 yrs of F/U, RA was found in 1.1% of MC vs 0.6% controls (adj HR 1.92 (95% CI = 1.56-2.34). https://t.co/R5faYDoaAq https://t.co/qiaOMgOyLR

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Dr. John Cush RheumNow ( View Tweet)

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