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Lupus During Pregnancy Carries Higher Maternal, Fetal Morbidity Risks

d MedPage Today

Women with systemic lupus erythematosus (SLE) had higher risks for maternal and fetal morbidity compared to those without the chronic autoimmune disorder, according to a nationwide analysis of U.S. data.

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Pericarditis Management

d Eric Dein, MD

On the final day of ACR 2023 State of the Art Conference, Dr. Paul Cremer reviewed pericarditis management. Dr. Cremer, a cardiologist at the Cleveland Clinic Foundation, reviewed the questions patients ask about pericarditis including why the disease develops, will it recur, how is it treated, and what will their treatment duration be. 

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brain headache neuro

Treatment and Management of Neuropsychiatric Lupus

d Eric Dein, MD

On the first day of ACR State of the Art conference in Orlando, Florida, Dr. Michelle Petri reviewed the treatment and management of neuropsychiatric lupus. Dr. Petri, a lupus expert from Johns Hopkins Rheumatology, reviewed the latest clinical and animal model studies that offer hope in treatment and gave wide-ranging pearls on a variety of issues that can be faced in this disorder. 

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PJP Prophylaxis Needed with Steroids and RTX The 2023 EULAR Vasculitis guidelines recommends primary prophylaxis with antibiotics, especially in rheumatic disease patients receiving RTX. https://t.co/eq42bK7MB1 https://t.co/Wk1hOpXanv

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Dr. John Cush RheumNow ( View Tweet)
I want to thank all of our amazing contributors for @RheumNow’s Women in Rheumatology: The XX Factor month. @KDAO2011 @gwenesta_melton and I agree that the future looks brighter when we come together as a community.

Dr. Rachel Tate uptoTate ( View Tweet)

RheumThoughts: Giving Good Care in Diversity takes Time Dr. Yvonne Sherrer and second-year fellow Dr. Corin Agoris discuss a case where extended time led to improved patient outcomes. https://t.co/j4QvtBCy6n https://t.co/kECx0yLqJg

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Dr. John Cush RheumNow ( View Tweet)
Stop RA trail: Plaquenil didn’t prevent RA in patient with pre clinical RA. Kevin Deane #RNL2023 ⁦@RheumNow⁩ https://t.co/0uQshODl1j https://t.co/sXIYyQeemJ

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Dr. John Cush RheumNow ( View Tweet)
#RNL2023 @RheumNow There are a lot of RA Rx on market now - do we need more? Dr. Brenner: YES Stromal targets like LIF/LIFR, Notch3, cadherin-11 offer upstream benefits for our difficult to treat RA patients that don't respond to tradition cs/bDMARDs https://t.co/xavJrFX84G https://t.co/gAdMU4AgXz

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Dr. John Cush RheumNow ( View Tweet)
Dr Brenner at #RNL2023 Excellent description on how fibroblasts are major producers of IL-6 producers Clinically presents a target for blocking the fibroblasts, upstream the inflammatory cascade in RA @RheumNow https://t.co/9eQDkEzLBS https://t.co/nOGsjJH7AI

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Dr. John Cush RheumNow ( View Tweet)
5 year retrospective study of hip replacements (w/ RA, PsA, OA, AS pts), looked at those w perioperative TNFi vs stopped TNFi; showing no differences in outcomes (p = 0.713)> @ last F/U, revision rates were TNFi 2.5%, nonbiologics 3% & 0.8% OA THAs https://t.co/fMKJLyMO6A https://t.co/FofBlxmNEt

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Dr. John Cush RheumNow ( View Tweet)
#RNL2023 @RheumNow Dr. Stanley Cohen: possible adverse effects of JAKi -Herpes zoster, other infections -Malignancy -Occasional cytopenias -LFTs (with DMARDs) -Incr Cr or CPK -Acne -Incr lipids -GI perf -VTE Which do you counsel with your patients? https://t.co/WNqQ8HVP9n https://t.co/qWYLoMWELv

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Dr. John Cush RheumNow ( View Tweet)
JAKi cycling, likely something we all do/consider in clinic. Dr. S. Cohen reviews the JAK-pot study which shows good, expected results between cycling in patients. #RNL2023 ⁦@RheumNow⁩ https://t.co/72m0GnmBkZ https://t.co/IThonRjpWD

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Dr. John Cush RheumNow ( View Tweet)
How do you prevent RA in at-risk patient? Smoking cessation! Healthy weight and exercise! Diet! Periodontal health! 🚭🏋️🥕🦷 Education follow-up! Not robustly proven to prevent/delay RA, but may be more important than early DMARD intervention! Kevin Deane, MD #RNL2023

Dr. John Cush RheumNow ( View Tweet)

Korean retrospective claims analysis of #RA (n=54 .7K; 39K RF/CCP+) (2010-2019; F/U 4.3 yrs) saw Parkinsons dx in 290 RA; Compared to controls, RA had a significant 1.74-fold higher risk of PD (found in seropos HR 1.95) but not seroneg RA https://t.co/GRahCXDuYt https://t.co/ohWK51frFr

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Dr. John Cush RheumNow ( View Tweet)
Treatment with MTX in early CCP+ RA thought to be effective in slowing disease however StopRA study did not show a difference between HCQ and PBO in patients. We need to know more about HCQ vs MTX in this space! #RNL2023 https://t.co/hkypaEwZ8F cc: @uptoTate https://t.co/hgZNyU8YwU

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Dr. John Cush RheumNow ( View Tweet)
STOP-RA study on HCQ preventing RA... HCQ did NOT prevent RA development in pre-RA pts @RheumNow #RNL2023 https://t.co/h1YicTORuw https://t.co/JRIFJzMudO

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Dr. John Cush RheumNow ( View Tweet)
#RNL2023: Kevin Deane: Anti-CCP positive leads to a 20-30% risk for articular clinical RA within 3-5 years https://t.co/YrA7tXMKoI Cc: @ericdeinmd https://t.co/oXoeZYW7rU

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Dr. John Cush RheumNow ( View Tweet)
#RNL2023 Kevin Deane: natural history of RA The onset of RA is a spectrum of disease from genetic/environmental risks; local & systemic autoimmunity (ACPA/RF, mucosal factors); subclinical; unclassified arthralgias; classified RA When to start treatment? https://t.co/LEsPVQe9QW https://t.co/MbNmxZ39HO

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Dr. John Cush RheumNow ( View Tweet)
Retrospective study of Calif. Hosp. records on women with SLE (n 2874) and RA (2309) found that Black, Hispanic, and Asian women had 1.3 - 1.5 fold more preterm births than Whites; & blacks had 2-2.4 more PTB than Asian, Hispanic, or Whites. https://t.co/7Nr5KJUNRc https://t.co/3fzTMiM4DG

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Dr. John Cush RheumNow ( View Tweet)
Swedish study looked at risk of PsA in psoriasis pts showing PsA risk was significantly higher w/ worsening psoriasis. Incidence of PsA was 1.48/100PY, 3.00, and 5.49/100PY w/ mild, moderate and severe psoriasis. PsA risk was 3.2X higher w/ severe PSO https://t.co/H8QbkRp4d9 https://t.co/Hqlcf3f2bI

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Dr. John Cush RheumNow ( View Tweet)

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