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PsA Til Death Do Us Part (1.20.2023)
Dr. Jack Cush reviews the highlights from the past week on RheumNow.com.
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AS, but not PsA, has Increased Mortality Risk
Inflammatory disorders are often accompanied by an increased mortality risk, either from secondary malignancy, infection or cardiovascular disease.
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Phase III Trials Back Bimekizumab for Spondyloarthritis
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Medpage Today
Bimekizumab, an investigational biologic drug targeting interleukin (IL)-17A/F, appeared highly effective in patients with axial spondyloarthritis (axSpA), researchers said.
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Hydroxychloroquine Dose and Risk for Incident Retinopathy
A cohort study in Annals of Internal Medicine shows that higher hydroxychloroquine doses was associated with progressively greater risk for incident retinopathy.
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Poorer health outcomes for at-risk patients with fractures
People at high risk of fracture who also have complex or multiple chronic medical conditions are less likely to receive treatment for the underlying osteoporosis and also have poorer health outcomes, according to a new study from the Garvan Institute of Medical Research.
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Hydroxychloroquine Dose and Risk for Incident Retinopathy
A cohort study in Annals of Internal Medicine shows that higher hydroxychloroquine doses was associated with progressively greater risk for incident retinopathy.
https://t.co/DZ2UxDKgUD https://t.co/tFtNZc1Eza
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Poorer health outcomes for at-risk patients with fractures
People at high risk of fracture are less likely to receive treatment for the underlying osteoporosis and also have poorer health outcomes.
https://t.co/XmFcnBf6US https://t.co/mgAkb0NLBv
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Dr. John Cush RheumNow ( View Tweet)
Rx failures w/ nonmedical switching of biosimilars may be Nocebo effect. 140 #RA pts, 51 non-switchers & 89 switchers. Non-switchers more likely to improve than switchers (68 vs 26%, p < 0.001) and less likely to worsen (1% vs 9%, p < 0.01). https://t.co/w8lnv1V5Pi https://t.co/iT2RkkSosl
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Naltrexone is indicated in opioid or EtOH dependence - not pain; yet it has wide off-label uses. Shown to be equal to Elavil in Rx of painful DM neuropathy; Little data from PBO RCTs in FM. Unclear how naltrexone modulates pain https://t.co/YZvfbHy9KJ https://t.co/6k9LfQSp1A
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What RheumNow Live attendees say about our meeting:
"Great format w/shorter lectures, clinical content, good interface for audience participation to ask questions, and on-demand availability of videos post-meeting."
Join us!
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New Guideline: Vaccinations OK for Rheum Patients
Nearly all available vaccines can be given to people w/ rheumatologic diseases, according to a new guideline from the ACR, though the timing for their administration and dosing may need adjustment.
https://t.co/kHWyrmjkuw https://t.co/LrcFrZR2TO
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PsART-ID study of 1216 #PsA pts showed PsA mortality to be similar to general population, but during pandemic PsA mortality doubled (5.1 vs 10.86 pandemic) with a higher increase in females (2.9 vs 8.72) than males (9.07 vs 14.73) https://t.co/AzhjOlW8vh https://t.co/YF7OlEh0sK
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US study of 47 #GCA pts showed baseline US+ in 44/47 (72% TA, 72% LV). US was sensitivity to change over time w/ serial measures. TA-based US showed good correlation w/ Dz activity & discriminated remission vs, relapse https://t.co/2cDxac5oJw https://t.co/jH4rgvgELY
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International survey of 394 GPs & 937 rheumatologists shows most PMR pts are not referred to Rheum. GPs referred 25% suspected PMR for Dx & 50% were returned to GP. 39% of Rheums saw new PMR >2 weeks after referral, half already on Pred https://t.co/K56nYRckpz https://t.co/j6ukqPaQXd
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Danish registries stud of > 6 million persons finds 52898 new #IBD pts (over 18 yrs). Antibiotic exposure was assoc w/ increased risk of IBD, esp > 40 yrs. (40–60 yrs IRR 1.48; ≥60 yrs IRR 1.47) https://t.co/3P5WSjZm8M https://t.co/xHNFMWQ8dC
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Dr. John Cush RheumNow ( View Tweet)
New Hope for Hand Osteoarthritis
The drug talarozole – which increases retinoic acid – could be a promising new treatment for hand osteoarthritis.
https://t.co/WEJZCYqm8K https://t.co/7RHESoGuYJ
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Dr. John Cush RheumNow ( View Tweet)
Lupus Research Alliance (LRA) is pleased to announce the appointment of Stacie J. Bell, PhD as Executive Vice President to lead Lupus Therapeutics, the organization’s clinical research affiliate. Dr Bell was prev CMO of the Natl Psoriasis Foundation https://t.co/deCIo8lI5Y https://t.co/dBodyzWtsi
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Opioids and Health Care Utilization in PsA and AS
Dr Aurelie Najm discusses Abstract 0402 presented at ACR22 Convergence in Philadelphia, PA. Abstract 0402: Opioid Use and Healthcare Utilization in Adults with PsA and AS
https://t.co/GsTwHbXVLm https://t.co/22i3yskUpA
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Dr. John Cush RheumNow ( View Tweet)
Join us on 3/18 and 3/19 in Dallas, Texas or virtually for RheumNow Live!
RheumNow Live is unlike any meeting you've ever attended. Here's why:
-Inspired Education
-The Audience Matters
-Never Seen Before
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Elevated Uric Acid Is Associated With New‐Onset Atrial Fibrillation
A Longitudinal Swedish study has shown that elevated serum uric acid (SUA) levels has cardiovascular implications and may predict the development of atrial fibrillation (AFib).
https://t.co/C3D0fbCEjE https://t.co/70CXgwVFAH
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