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Rheum Believe it Or Not (1.13.2023)

d Jack Cush, MD

Dr. Jack Cush reviews the notable standouts in the news since the 1st of January.  Surprising reports on ferritin, alcohol benefits, cannabis for pain and a lower dementia risk with hydroxychloroquine.  Here are the links below.

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RA Disease Activity and Alcohol Use

d Jack Cush, MD

Despite its well known toxicities, alcohol is known to be antiinflammatory. The effects of alcohol use in rheumatoid arthritis (RA) is less known, but a recent study suggests that alcohol consumption was dose-dependently associated with lower disease activity and higher health-related quality of life in RA patients.

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Free great handout on DRESS - Drug Reaction With Eosinophilia and Systemic Symptoms. May affect adults or children; usually 2 to 8 weeks after beginning a medication. ~1 in 1000 taking specific drugs get DRESS. Allopurinol is a common cause https://t.co/gTW8D3raHV https://t.co/aQbnFS3rNR

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anti-mitochondrial antibodies (AMA) in were assayed in 404 #RA patients & found to positive in 14-26%. Importantly AMA Abs were associated with erosive disease (p<0.05) and interstitial lung disease (p<0.01), independent of CCP or RF https://t.co/TW2xsa1igt https://t.co/jr1ltgGmdF

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AutoAb analysis of 140 systemic sclerosis shows low sensitivity (<33%), high specificity (>88%). Scl-70+ signif assoc w sine scleroderma, digital ulcers, Raynauds as 1st onset sign. SSc-ILD more common Scl-70 and PAH with CENP A/B Abs https://t.co/ZQksWVauMZ https://t.co/RKSWOItdxu

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Evidence based Latin American Guidelines of clinical practice on prevention, diagnosis, management and treatment of glucocorticoid induced osteoporosis. A 2022 update https://t.co/CmYnENB60W https://t.co/Qm5hR1fCx6

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Neutrophil-to-lymphocyte ratio (NLR) was studied in 205 Idiopathic pulmonary fibrosis (IPF) pts - NLR correlated with lung function, & outcomes - NLR >= 2.9 was associated with a significant 2 fold increased risk of mortality https://t.co/FwnfrVW29M https://t.co/BIX8e3svJB

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Hosp study of 2809 admissions, found 1+adverse events (AE) in 24%. Among 978 AE, 23% (222) were preventable; 32% (316) serious. Preventable AE occurred in 1/15 admissions (serious 1/100). Drug AE were most common (39%) https://t.co/YKaYgmRbLN

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Join us on 3/18 and 3/19 in Dallas, Texas or virtually for RheumNow Live! RheumNow Live is unlike any meeting you've ever attended. Here's why: -Inspired Education -The Audience Matters -Never Seen Before https://t.co/qKoBckRNK1 https://t.co/2tyLsxV0L7

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Bimekizumab in Active Psoriatic Arthritis - BE COMPLETE study https://t.co/S4V3rf4cDc https://t.co/XyZMp1CrsX

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473 RA pts from the BeSt study were analyzed. for correlation betw joint cumulative inflammation and radiographic damage. Cumulative jt swelling was signif correlated w/ future xray damage/erosions, less so for tender only jts https://t.co/DQ06VYBDxm https://t.co/PfRWCcti8T

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Case crossover study of 508 #RA pts starting biologics (75% on steroids) showed significantly higher rates of RA flares if steroid doses taken down ≤2.5 mg/d (vs >2.5 mg/d) - adj OR of 1.37 to 1.45 https://t.co/sjkw6LJI0W https://t.co/k0jgnui5CH

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Degeneration seen in #OA may be related to cartilage tissue stiffening with the repression of a key longevity protein α-Klotho brought about by epigenetic changes. Downregulated Klotho gene expression accelerated chondrocyte senescence https://t.co/HBLeLIlmJG https://t.co/T7d6EodDYN

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ACR GCA classification criteria tested in 676 patients suspected GCA (+US) - 276 dx w/ GCA; 400 not. Sensitivity was 87%, specificity 70%; 35 (13%) GCA pts did not meet criteria. & 119 non-GCA (30%) had ≥6 points (most PMR) https://t.co/bTrj83yM7l https://t.co/9iA8LbX6vB

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Rheumatologists: What do you devote your weekends to?

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2022 ACR Classification Criteria for GCA: (must be >50yrs) 6+ points needed for #GCA AM stiff should/neck +2 Visual loss +3 Jaw Claud +2 Temp HA +2 Scalp tender +2 Hi ESR/CRP +3 +Bx or US +5 axillary +2 +PEG Aorta +2 https://t.co/ZtVlYhpwru https://t.co/L1sv3L9p37

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Register for RheumNow Live today and qualify for early bird pricing. Among our 24 speakers, Drs. Coates, Ruderman, and Champers will lead a session on the Modern Management of Psoriatic Arthritis. https://t.co/tiJssRdzAw https://t.co/Rar27hRahf

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Population data on incidence of #RA from Northern Savo, Finland, 46 new RA cases in 2020; incidence seropos RA was 22.3 per 100K. Incidence did not differ by gender but decreased w/ age < 55 years, p = 0.003 (change in risk factors?) https://t.co/QxMwKh7wIU
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Ferritin may be more than biomarker in Stills, etc - may contribute directly to pathogenesis. Ferritin causes PMN activation & neutrophil extracellular traps (NETs). Could this be targeted therapeutically? https://t.co/42KeTbVsQb https://t.co/imLipzmf4R

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ACP Guidelines on Fracture Prevention in at-risk Adults The American College of Physicians (ACP) has updated its 2017 recommendations on pharmacologic treatment of primary osteoporosis or low bone mass to prevent fractures in adults. https://t.co/FE6WEs1Oug https://t.co/Mvgx8sVLPh

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