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PsA Til Death Do Us Part (1.20.2023)
Dr. Jack Cush reviews the highlights from the past week on RheumNow.com.
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AS, but not PsA, has Increased Mortality Risk
Inflammatory disorders are often accompanied by an increased mortality risk, either from secondary malignancy, infection or cardiovascular disease.
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Danish registries stud of > 6 million persons finds 52898 new #IBD pts (over 18 yrs). Antibiotic exposure was assoc w/ increased risk of IBD, esp > 40 yrs. (40–60 yrs IRR 1.48; ≥60 yrs IRR 1.47) https://t.co/qU1OxXr7Gj https://t.co/YMh6L514By
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Dr. John Cush RheumNow ( View Tweet)
New Hope for Hand Osteoarthritis
The drug talarozole – which increases retinoic acid – could be a promising new treatment for hand osteoarthritis.
https://t.co/AHoEZM75mh https://t.co/dZ1LWWoNl5
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Dr. John Cush RheumNow ( View Tweet)
Elevated Uric Acid Is Associated With New‐Onset Atrial Fibrillation
A Longitudinal Swedish study has shown that elevated serum uric acid (SUA) levels has cardiovascular implications and may predict the development of atrial fibrillation (AFib).
https://t.co/5PIOC4ymhB https://t.co/HRAe2tIerJ
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Dr. John Cush RheumNow ( View Tweet)
UK BADBIR cohort study of 9057 PsA & PsO pts. A greater comorbidity burden and work inability seen PsA vs PsO cohort. PsA (HR 1.98), female sex & depression (HR 1.21) were associated with shorter persistence on ustekinumab. https://t.co/aBILQqXDKl https://t.co/tLNIhnxdXO
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Dr. John Cush RheumNow ( View Tweet)
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Causes of Enthesitis: SpA (AS, reactive arthritis, PsA, enteropathic arthritis, ERA), JIA, but also in RA, leprosy, trauma, OA, DISH, acromegaly, fluorosis, retinoid therapy, hypo- or hyper-PTH, POEMS syndrome, X-linked hypophosphatemia https://t.co/pff2OWBT5C https://t.co/7zm2la4GtD
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Tofacitinib and RA-ILD
Dr. Richard Conway discusses Abstract 2251 at ACR22 Convergence. Abstract 2251: Reduction in Rheumatoid Arthritis-Associated Interstitial Lung Disease Risk in Patients Treated with Tofacitinib
https://t.co/inndpqqbi8 https://t.co/8tRiKqT1x5
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Ferritin may be more than biomarker in Stills, etc - may contribute directly to pathogenesis. Ferritin causes PMN activation & neutrophil extracellular traps (NETs). Could this be targeted therapeutically? https://t.co/yuvMaKqOa7 https://t.co/bjkEJvKH8d
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PsA Til Death Do Us Part
Dr. Jack Cush reviews the highlights from the past week on RheumNow
https://t.co/8km1IGdmkZ https://t.co/Drxqq1QYsC
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Dr. John Cush RheumNow ( View Tweet)
Hydroxychloroquine Dose and Risk for Incident Retinopathy
A cohort study in Annals of Internal Medicine shows that higher hydroxychloroquine doses was associated with progressively greater risk for incident retinopathy.
https://t.co/DZ2UxDKgUD https://t.co/tFtNZc1Eza
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Dr. John Cush RheumNow ( View Tweet)
Poorer health outcomes for at-risk patients with fractures
People at high risk of fracture are less likely to receive treatment for the underlying osteoporosis and also have poorer health outcomes.
https://t.co/XmFcnBf6US https://t.co/mgAkb0NLBv
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Rx failures w/ nonmedical switching of biosimilars may be Nocebo effect. 140 #RA pts, 51 non-switchers & 89 switchers. Non-switchers more likely to improve than switchers (68 vs 26%, p < 0.001) and less likely to worsen (1% vs 9%, p < 0.01). https://t.co/w8lnv1V5Pi https://t.co/iT2RkkSosl
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Naltrexone is indicated in opioid or EtOH dependence - not pain; yet it has wide off-label uses. Shown to be equal to Elavil in Rx of painful DM neuropathy; Little data from PBO RCTs in FM. Unclear how naltrexone modulates pain https://t.co/YZvfbHy9KJ https://t.co/6k9LfQSp1A
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New Guideline: Vaccinations OK for Rheum Patients
Nearly all available vaccines can be given to people w/ rheumatologic diseases, according to a new guideline from the ACR, though the timing for their administration and dosing may need adjustment.
https://t.co/kHWyrmjkuw https://t.co/LrcFrZR2TO
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PsART-ID study of 1216 #PsA pts showed PsA mortality to be similar to general population, but during pandemic PsA mortality doubled (5.1 vs 10.86 pandemic) with a higher increase in females (2.9 vs 8.72) than males (9.07 vs 14.73) https://t.co/AzhjOlW8vh https://t.co/YF7OlEh0sK
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US study of 47 #GCA pts showed baseline US+ in 44/47 (72% TA, 72% LV). US was sensitivity to change over time w/ serial measures. TA-based US showed good correlation w/ Dz activity & discriminated remission vs, relapse https://t.co/2cDxac5oJw https://t.co/jH4rgvgELY
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