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Best of 2022: Allopurinol Safety in CKD Patients

d Jack Cush, MD

A study in the Annals of Internal Medicine reports chronic kidney disease (CKD) patients can be safely treated with allopurinol without an increased risk of mortality.

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Malar,rash,SLE, Lupus

Best of 2022: Emerging Therapeutics for Lupus

d Kathryn H. Dao, M.D.

Impressive data on novel treatment for SLE were presented at the EULAR22 Congress. A disease that is difficult to study due to its pleomorphic presentation, unpredictable disease course, and high mortality rates, SLE is considered the dragon of all autoimmune diseases. Here are highlights of four exciting abstracts presented at the meeting with emerging therapeutics designed to slay the beast. 

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computer screen safety

Best of 2022: Methotrexate Side Effects

d Jack Cush, MD

Data came from the UK Rheumatoid Arthritis Medication Study (RAMS), a prospective cohort of early RA patients starting methotrexate (MTX) shows that in the first year, adverse events (AE) were common, but not serious.

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Full read review of advances in bone biology leading to drug development (denosumab, romosuzumab, Burosumab), advances in Pagets and rickets and key regulatory molecules for bone remodeling, RANK, RANKL, OPG, & sclerostin https://t.co/1d6A6MsdbJ https://t.co/IuKEp1PQtr

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Dr. John Cush RheumNow ( View Tweet)
Best of 2022: The Enthesitis Challenge in Psoriatic Arthritis https://t.co/S7OR6zXTiw https://t.co/Mgy4IcoIZj

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Dr. John Cush RheumNow ( View Tweet)
JAMA - Update/Review of Hemochromatosis Dx and Rx. - 5 gene defects in hepcidin. 95% HFE & the C282Y variant - 90% are asymptomatic - Suspicion w/ arthralgias, LFTs, hepatomegaly, cardiomyopathy, 1st degr relative - Untreated, 9% risk of cirrhosis https://t.co/LWbIbLITK9 https://t.co/xDpA16K0tm

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Dr. John Cush RheumNow ( View Tweet)
Hyaluronic Acid Knee Injections Equivalent to Placebo In the United States, where over $300 million is spent annually on intraarticular hyaluronic acid injections, yet another study shows such therapy to be no better than placebo. https://t.co/bBEwpId84L https://t.co/5msGqViTpz

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Dr. John Cush RheumNow ( View Tweet)
Drug-Induced Lupus from Proton Pump Inhibitors A wide range of therapies have been implicated in causing drug-induced lupus erythematosus (DIL); now it appears that proton pump inhibitors (PPIs) can be added to the list of causative drugs. https://t.co/Jp3oNUhP6c https://t.co/AcC4mM0nLM

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Dr. John Cush RheumNow ( View Tweet)
Effect of Intraarticular Steroid Shots on Knee OA Outcomes In patients with osteoarthritis of the knee, intra-articular injections of steroids did not increase rates of either disease progression or subsequent knee replacement surgery, researchers said. https://t.co/yqVHPmqzzi https://t.co/k8dMADHg7P

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Dr. John Cush RheumNow ( View Tweet)
JAMA - Update/Review of Hemochromatosis Dx and Rx. - 5 gene defects in hepcidin. 95% HFE & the C282Y variant - 90%are asymptomatic - Suspicion w/ arthralgias, LFTs, hepatomegaly, cardiomyopathy, 1st degr relative - Untreated, 9% risk of cirrhosis https://t.co/xFTMqkOMSE https://t.co/CmiokvIGvD

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Dr. John Cush RheumNow ( View Tweet)
Best of 2022: Methotrexate Side Effects https://t.co/ySFyjwYQPX https://t.co/HjlvUzrG9n

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Dr. John Cush RheumNow ( View Tweet)
#POTS Postural orthostatic tachycardia syndrome - how it might link to other conditions https://t.co/Ekn6KtOrC4 #Fibromyalgia #chronicillness #migraine #hypermobility #EDS https://t.co/JX1WDm2KKn

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Dr Gurdeep Dulay gurdeep_dulay ( View Tweet)
$520 billion is the estimated cost of physical inactivity from 2020 to 2030 @LancetGH: https://t.co/JynmtU9oCF Of the expected 500 million preventable cases of disease, 43% due to #depression and #anxiety. #MentalHealthMatters @fiona_bull https://t.co/sVjkceNGiq

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Scott Lear, PhD DrScottLear ( View Tweet)
No Special Heart Risk With JAK Inhibitors, Study Finds Patients taking JAK inhibitors for RA experienced similar cardiovascular outcomes as those using the TNF blocker adalimumab (Humira), analysis of French national registry data indicated. https://t.co/i0oUoTSmqF https://t.co/qrJMQbpqus

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Dr. John Cush RheumNow ( View Tweet)
Poncet’s disease: a reactive arthritis secondary to pulmonary M. tuberculosis https://t.co/qMorRZBbi8

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Dr. John Cush RheumNow ( View Tweet)

Best of 2022: EULAR 2022 Top 10 Abstracts https://t.co/1PhxJcY9mD https://t.co/tHby7HmSzw

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Dr. John Cush RheumNow ( View Tweet)

Anakinra in Pericarditis: A Systematic Review (comprehensive, full read) -Options include steroids, colchicine, NSAIDs, pleuropericardial window, IL-1 inhibitors. ANAKINRA - 11 studies, 259 pts, all showing significant rapid resolution. https://t.co/i0LRp4E1tH https://t.co/lGLjJRB1G9

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Dr. John Cush RheumNow ( View Tweet)
Three (3) Worst Drugs to use in #Lupus patients who want to be pregnant (MTX, MMF, CTX) #UTSWSLE2022 https://t.co/nBBUlWXmhw
Dr. John Cush RheumNow ( View Tweet)
Cool NEJM Case of Spinal Gout in 82-yr-old woman with 3-wk hx of severe LBP, rigors, anorexia, incomplete urination. Hx of PsA, CKD, CHF treated w/ Humira, HCQ, diuretics. Imaging tophi in spine, responded to steroids and allopurinol. https://t.co/Ny50BLk7H3 https://t.co/OOqjpmc1DA

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Dr. John Cush RheumNow ( View Tweet)
New download available. DMARD and Biologic Safety Prescribing https://t.co/Bfety3ob3i https://t.co/S57mVT5MgR

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Dr. John Cush RheumNow ( View Tweet)

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