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Periprosthetic Joint Infections

d Jack Cush, MD

Recent NEJM has reviewed arthroplasty-associated infection and periprosthetic joint infections (PJI), noting this is a rare event; notably these infections are caused by skin microorganisms introduced during arthroplasty surgery or may be seeded post-surgically, via hematogenously spread or compromised local tissues (skin or bone).

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JAK Janus

JAK-pot Study: To Cycle or Switch after JAK inhibitor Failure?

d Jack Cush, MD

Data from 17 international registries (JAK-pot collaboration) suggest that for Rheumatoid arthritis (RA) patients failing their first janus kinase inhibitor (JAKi), it did not matter if they were cycled to another JAKi or switched to a biologic disease-modifying antirheumatic drug (bDMARD).

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Scale,weight

Burden of BMI on Costs of Musculoskeletal Diseases

d Jack Cush, MD

A cross-sectional global study shows a substantial impact of obesity and BMI on the health and economic impact of patients with musculoskeletal (MSK) disorders.

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Korean study of 439 RA pts starting JAKi, TNFi or non-TNFi. Physician choice of JAKi was more likely with age (OR 1.03), no pulmonary Dz (OR 0.07), Higher Dz activity (OR 1.80) & prior tacrolimus (OR 2.05) https://t.co/9Vv5XfzfrH https://t.co/59Whi7tCIE

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JAMA: 13 million In US have latent TB (5-10% risk of getting active TB). Review of LTBI regimens: - Preferred: 4 mos Rifampin: better/safer of INH - Preferred: 3 mos of INH + rifapentine - more completers less SAE - ALternative: 6-9 mos of INH https://t.co/vZTmSKTFWu https://t.co/W7BraJs6yC

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PsA Til Death Do Us Part Dr. Jack Cush reviews the highlights from the past week on RheumNow https://t.co/nSogWCSbi9 https://t.co/nZ9jWu20Xy

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AS, but not PsA, has Increased Mortality Risk A recent meta-analysis showed a significantly increased risk of overall mortality in ankylosing spondylitis (AS) but not psoriatic arthritis (PsA), largely associated with cardiovascular-specific mortality. https://t.co/gnd0bMQIui https://t.co/sWFhJAIaGH

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Phase III Trials Back Bimekizumab for Spondyloarthritis Bimekizumab, an investigational biologic drug targeting interleukin (IL)-17A/F, appeared highly effective in patients with axial spondyloarthritis (axSpA), researchers said. https://t.co/pdfxa3u29k https://t.co/0wLl48Fvj6

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PRedSS was a small trial of 35 pts with early diffuss systemic sclerosis Rx w/ prednisolone(17) vs placebo(18). At 3 mos outcomes favored Pred, but nonsignificant (HAQ-DI -0.10; p= 0.25 & mRSS -3.90; p= 0.07), but less pain & anxiety https://t.co/iZw2L9SLhF https://t.co/2G2MuVMUSJ

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Danish registries stud of > 6 million persons finds 52898 new #IBD pts (over 18 yrs). Antibiotic exposure was assoc w/ increased risk of IBD, esp > 40 yrs. (40–60 yrs IRR 1.48; ≥60 yrs IRR 1.47) https://t.co/qU1OxXr7Gj https://t.co/YMh6L514By

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New Hope for Hand Osteoarthritis The drug talarozole – which increases retinoic acid – could be a promising new treatment for hand osteoarthritis. https://t.co/AHoEZM75mh https://t.co/dZ1LWWoNl5

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Elevated Uric Acid Is Associated With New‐Onset Atrial Fibrillation A Longitudinal Swedish study has shown that elevated serum uric acid (SUA) levels has cardiovascular implications and may predict the development of atrial fibrillation (AFib). https://t.co/5PIOC4ymhB https://t.co/HRAe2tIerJ

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UK BADBIR cohort study of 9057 PsA & PsO pts. A greater comorbidity burden and work inability seen PsA vs PsO cohort. PsA (HR 1.98), female sex & depression (HR 1.21) were associated with shorter persistence on ustekinumab. https://t.co/aBILQqXDKl https://t.co/tLNIhnxdXO

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Join us! Take advantage of our early bird pricing. https://t.co/9Up0ZgaRP2 What attendees say about our meeting: 100% found the program free of commercial bias. 99% would recommend RheumNow Live to colleagues. 95% describe the content as extremely relevant to their practice. https://t.co/HOmh0CMyyJ

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Causes of Enthesitis: SpA (AS, reactive arthritis, PsA, enteropathic arthritis, ERA), JIA, but also in RA, leprosy, trauma, OA, DISH, acromegaly, fluorosis, retinoid therapy, hypo- or hyper-PTH, POEMS syndrome, X-linked hypophosphatemia https://t.co/pff2OWBT5C https://t.co/7zm2la4GtD

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Tofacitinib and RA-ILD Dr. Richard Conway discusses Abstract 2251 at ACR22 Convergence. Abstract 2251: Reduction in Rheumatoid Arthritis-Associated Interstitial Lung Disease Risk in Patients Treated with Tofacitinib https://t.co/inndpqqbi8 https://t.co/8tRiKqT1x5

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Ferritin may be more than biomarker in Stills, etc - may contribute directly to pathogenesis. Ferritin causes PMN activation & neutrophil extracellular traps (NETs). Could this be targeted therapeutically? https://t.co/yuvMaKqOa7 https://t.co/bjkEJvKH8d

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Join RheumNow Live in person or virtually on 3/18 and 3/19. This meeting is unlike any other meeting you attended. But don't take our word for it, last year's attendees say: "Great conference. Best in the last year. I did Hopkins, CCR, and ACR too" https://t.co/jvhKcVXNtz https://t.co/Hc6SzsPKNa

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PsA Til Death Do Us Part Dr. Jack Cush reviews the highlights from the past week on RheumNow https://t.co/8km1IGdmkZ https://t.co/Drxqq1QYsC

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Hydroxychloroquine Dose and Risk for Incident Retinopathy A cohort study in Annals of Internal Medicine shows that higher hydroxychloroquine doses was associated with progressively greater risk for incident retinopathy. https://t.co/DZ2UxDKgUD https://t.co/tFtNZc1Eza

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