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JAK Inhibitor Potential in Systemic Sclerosis-Associated ILD

d Jack Cush, MD

The occurrence of interstitial lung disease (ILD) in Systemic sclerosis portends serious morbid and mortal outcomes for those affected. This review examines the available clinical literature on the potential benefits and outcomes of JAK inhibitor use in SSc=ILD.

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Vegetarian diet food nutrition

ACR New Guidelines on Integrative Approach to RA

d ACR

The American College of Rheumatology (ACR) released a summary of its new guideline for Exercise, Rehabilitation, Diet and Additional Integrative Interventions for Rheumatoid Arthritis.

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lupus SLE

CXCL5 Therapy in Lupus?

d EurekAlert!

 A new study has shown that restoring the balance of a protein in blood may be a promising treatment option for systemic lupus erythematosus.

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Marginal Benefit with Diet and Exercise in Obese Knee Osteoarthritis Patients

d Jack Cush, MD

The easiest intervention for knee osteoarthritis (diet and exercise) is also the most difficult for many patients; but do these work? A new study of a weight loss and exercise program in community settings shows only marginal benefits. 

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Get the Skinny on Bimekizumab in PsA Dr. Janet Pope discusses abstract presented at #ACR22. https://t.co/FKFARxQ2fa https://t.co/wSyXeSHII3

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During 2021–22 FLU season, 6% of hosp pedi-influenza pts had SARS-CoV-2 coinfection; these required more respiratory support. Risk of influenza death augmented by not recv vaccination (flu or covid), no antiviral Rx, comorbidities & coinfx w/COVID https://t.co/bfjeClHflW https://t.co/YTOEnNSQQN

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Lupus Research Alliance announced 2022 Distinguished Innovator Award recipients: - Hongbo Chi, PhD, Exploring Metabolism of Follicular Helper T Cells & Lupus Progression - Joseph Craft, MD: Processes Enabling T Cells to Be Destructive in Lupus Nephritis https://t.co/yI2NlCHaBi https://t.co/fevBTkaxCY

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#OA phenotypes by SF cell status - Activated: hi T-cell, low mono–macrop-PMN activated; 70% improved - Lymphoid: hi PMN, low lymph & mono, low activ, lower pain - Myeloid: hi NK & mono, low T-cell & activat - Aggressive: hi lymph/macr/NK/PMN;39%improve -https://t.co/3DXPoDE5Pm https://t.co/VRJkscAm5a

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Comorbidities in Axial Spondyloarthritis Dr. Antoni Chan discusses Abstract 1609 at ACR22 Convergence. https://t.co/dCLlgiGV9K https://t.co/a4iI1q3zZC

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Will a vegetarian diet and exercise actually help RA disease activity? https://t.co/NI6xmhN0sO https://t.co/7IlQWkXkE1

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Dr. John Cush RheumNow ( View Tweet)
A&R: Climate Emergency and the Health of Our Patients - A public health crisis that will affect Rheum pts - climate factors can worsen Dz - Pollution causes autoimmunity - Climates worse effects on the vulnerable - Advocacy solutions research are needed https://t.co/JJufiImhND

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Efgartigimod Treatment in Chronic Primary ITP https://t.co/iJMeG2CJJv https://t.co/OXE7CuScBC

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Substandard Therapy in RA Clinicians could improve outcomes in their patients w/ RA by paying attention to certain markers of care quality, like early referral to certified rheumatologists and prescribing standard drugs for RA, new research suggested. https://t.co/Ln6XQHLVJE https://t.co/454Ff8dEr8

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Practical Guidance for the Clinical Rheumatologist in Unplanned Pregnancies Women of reproductive age comprise an overwhelming majority of patients with rheumatic and musculoskeletal disease. https://t.co/45ABQ0e2Qy https://t.co/dhLqzjf9uL

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Dr. John Cush RheumNow ( View Tweet)
NIH has granted $4.7 million to fund OHSU/UAB/UNC scientists to develop Novel 2-Pyrimidone (SRI-42718) Chikungunya antiviral drug. 2022: >360,000 Chikungunya cases w/ 77 deaths (mostly Brazil, India Guatemala) w/ 13 acquired in U.S. https://t.co/5ospHoFBBQ https://t.co/E1WKvdhaUO

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Swedish study of 4033 incident RA vs 6485 controls - Exposure to occupational inhalable increased risk ACPA+ RA (OR 1.25). Occupational inhalable agents plus smoking and shared epitope markedly elevated risk (OR 18.22) esp in ACPA+RA https://t.co/4lKLEhkURm https://t.co/HFhz8lMR10

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Study of 172 febrile pts w skin rash + arthralgia; 112 Dx w/ #AOSD. Use of a "streamlined diagnostic process (looking @ neutrophilia, hyperferritinemia, high IL-18), shortened Dx time (2 vs 4 wks), earlier Dx and more remissions (85% vs 68%, p < 0.05) https://t.co/MSMq2XLeYA https://t.co/ECKkeVqTIW

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Biosimilar Bonanza in 2023 Dr. Jack Cush reviews more than a dozen news and journal articles from this past week on RheumNow https://t.co/FILyCcSThn https://t.co/kBxzZgs6rM

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2022 ACR/EULAR Giant Cell Arteritis Classification Criteria Giant cell arteritis (GCA) has historically been a clinical diagnosis (visual loss, headache, jaw pain, scalp tenderness, etc) supported by labs and histopathology. https://t.co/inHKcdXLmD https://t.co/g9v1zWkmRp

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Small, open label study of 43 RA pts Rx w/ csDMARDs randomized to denosumab or PBO x 24 weeks. Erosions of MCP 2,3 assessed by HR-pQCT shows no significant differences in erosions or safety signals at 6 mos between groups. https://t.co/AuysVPFD4S https://t.co/yQ4R41hSMi

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