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New Drug Formulations – For Patients or Profits?
Wang et al., in a JAMA Network Research Letter, recently reviewed Medicaid expenditures on adalimumab (ADA), sold under the brand name HUMIRA®. They noted that the introduction of the citrate-free formulation cost an extra $4.4B to Medicaid between 2014 and 2021.
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Heavy Metals and the Risk of Arthritis
The etiology of arthritis was studied using US National Health and Nutrition Examination Survey (NHANES) data and suggested that elevated concentrations of trace elements (TE: Pb, Cd, and Cu) were associated with increased risk of arthritis.
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Specific ACPAs and Autoantibodies Lead to RA-Associated ILD
A BRASS registry study shows that specific isotypes of anti-citrullinated protein antibodies (ACPAs) can be associated with incident rheumatoid arthritis-associated ILD (RA-ILD).
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Metanalysis of 25 studies, betw 1985 - 2021, showed US average annual visits for RA=5.25 for US rheums (vs 3.3 ex-US) & 4.8 US non-rheums. SLE=3.24 & 12.3 for US non-Rheums. FM=1.8 for US rheums & 0.4 vs ex-US Rheums. Rheum Visits Decreased 1982 to 2019 https://t.co/5ugk34MJ3b https://t.co/NDMYZT7pil
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Toxic Epiderman Necrolysis vs Acute Cutaneous Lupus Erythematosus
https://t.co/wKX3v01RUb https://t.co/SWwnH7ph04
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Specific ACPAs and Autoantibodies Lead to RA-Associated ILD
https://t.co/KLq3CYc20P https://t.co/G7u36CWOTn
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EHR study of UK Clinical Practice Research Datalink studied 318 hospitalized gout pts showing there is a 30d increased risk of VTE after gout flare aIRR 2.31 (1.39-3.82), that disappeared 31-90d after. https://t.co/h2v8KbiSwX https://t.co/gsfnR50gTD
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Vision Loss with ANCA-Associated Vasculitis
Shelley K. Dhillon, MD, presents her poster at RWCS 2023.
https://t.co/e25SFDXk7O https://t.co/J1AsdE3b0Y
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Danish Pop. study of frequency of TMJ and oro-facial Dz in 613 pts w/ #JIA followed 4 yrs. Cumulative incidence of TMJ dz was 30%; 21% had arthritis-induced dentofacial deformity & dentofacial dysfunction (52%). TMJ predicted by younger onset, F, ANA+ https://t.co/M39q3snO3n https://t.co/ajPz27lmvt
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Tigulixostat is a non-purine xanthine oxidase inhibitor studied in 143 gout pts vs PBO with goal of SUA < 5. TIG was effective at 50mg (47%), 100 mg (45% ), 200 mg (62%) vs PBO 2.6% at week 12; w/ more gout flares in PBO Rx pts (13% vs 9%) https://t.co/d9lAjCBUmZ https://t.co/BERW51HW2B
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PR3 autoreactive CD4+T cells found in affected kidneys of 72 pts with PR3+ ANCA assoc vasculitis. These cytotoxic GPR56+CD4+T cells were significantly greater in those with inactive (vs active GPA), suggesting they may be affected by immunosuppression
https://t.co/dHFhgnB8yE https://t.co/ZxV6INeCrU
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Gingival Inflammation Parallels Saliva “Cytokine Score”
Researchers at NYU College of Dentistry have developed a single score to describe the level of cytokines in the saliva, and this score is linked with the severity of clinical gum inflammation.
https://t.co/yIk4ddETeh https://t.co/6KNPe77LIV
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New Laboratory Insights for the ANA+ Consult
A new study suggests that use of ELISA assays for CXCL-10 and IFN-α can predict which ANA+ individuals may progress to developing a systemic autoimmune rheumatic disease (SARD).
https://t.co/vw4CMf6F0R https://t.co/moJcOr1LYf
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Differential Dx of Granulomatous Myopathy: Sarcoidosis, inclusion-body myositis, myasthenia gravis, Crohns, GPA, TB, brucellosis, syphilis, PBC, RA, systemic sclerosis , lymphoma, checkpoint inhibitors, GVHD, natural killer/T-cell lymphoma https://t.co/5IUaC1ln7G https://t.co/guYtvyaaHU
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S.Korean population based study shows the frequency of pregnancy induced de Quervain's tenosynovitis (DQT) between 2013-17 was 2.1% of all preg women. Risk factors: ≥ 30 yrs, multiple gestation, C-Section, HTN in preg, RA (DM not a risk) https://t.co/JaOQhaX5rL https://t.co/cl6RZLfXds
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IgG4 levels are often elevated and helpful, but not always. @anisha_dua @RWCSmtg @RheumNow #RWCS23 https://t.co/GLPWyXVLgq https://t.co/8rdXpGYWRZ
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Steroids assisting options - CTX, LEF or RTX @anisha_dua @RWCSmtg @RheumNow #RWCS23 https://t.co/gVw2tGKYNG https://t.co/ItIKB8MFTI
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Future therapies for IgG4 re dz. @anisha_dua @RWCSmtg @RheumNow #RWCS23 https://t.co/oDgCUD0Crr https://t.co/0QSrrxmeqM
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Case reports of anifrolumab use in 2 pts w/ chronic, scarring discoid lupus unresponsive to steriods, HCQ, immunosuppressants & CTX. Case 1 SLEDAI from 13 to 2 in 24 weeks & CLASI-A from 26 to 3 in 20wks. Cs 2 CLASI-A decr 24 to 5 after 1 infusion https://t.co/Qe2rF4Avxe
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Implantable Vagal nerve stimulation studied in 17 active #RA pts DAS ~6. Dr Eric Ruderman #RWCS23 https://t.co/GgjdcfuVud https://t.co/EpuGgApOq5
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