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RA Disease Activity and Alcohol Use

d Jack Cush, MD

Despite its well known toxicities, alcohol is known to be antiinflammatory. The effects of alcohol use in rheumatoid arthritis (RA) is less known, but a recent study suggests that alcohol consumption was dose-dependently associated with lower disease activity and higher health-related quality of life in RA patients.

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Worse Birth Outcomes in RA and SLE

d Jack Cush, MD

A population-based retrospective cohort study patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) and their infants demonstrated significant adverse pregnancy outcome, particularly the infants of women with SLE.

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Bimekizumab in Active Psoriatic Arthritis - BE COMPLETE study

d Jack Cush, MD

BE COMPLETE is published, showing that bimekizumab (BMK), a selective dual inhibitor of interleukin (IL)-17F and IL-17A, results in superior improvement in both skin and joint outcomes in psoriatic arthritis (PsA) patients who have previously failed treatment with a tumour necrosis factor-α (TNFα) inhibitor.

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Holes in TH17 cells release IL-1α on NLRP3 activation

d EurekAlert!

Certain T cells can secrete cytokines that are normally part of the innate immune system, as researchers from the Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI) and an international research team discovered.

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Ferritin may be more than biomarker in Stills, etc - may contribute directly to pathogenesis. Ferritin causes PMN activation & neutrophil extracellular traps (NETs). Could this be targeted therapeutically? https://t.co/42KeTbVsQb https://t.co/imLipzmf4R

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ACP Guidelines on Fracture Prevention in at-risk Adults The American College of Physicians (ACP) has updated its 2017 recommendations on pharmacologic treatment of primary osteoporosis or low bone mass to prevent fractures in adults. https://t.co/FE6WEs1Oug https://t.co/Mvgx8sVLPh

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Hosp study of 2809 admissions, found 1+adverse events (AE) in 24%. Among 978 AE, 23% (222) were preventable; 32% (316) serious. Preventable AE occurred in 1/15 admissions (serious 1/100). Drug AE were most common (39%) https://t.co/gqty53ccyH https://t.co/GxDBoEhxeM

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JAK Inhibitor Promising for Polymyalgia Rheumatica Tofacitinib appeared highly effective against PMR in a small single-arm trial, researchers said, suggesting another potential alternative to long-term corticosteroids. https://t.co/XNhICcDU7t https://t.co/WWHNRP3aeP

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"It takes alot of courage to reach out and say 'I need some help on this one'" (Carla Harris) Put on your big-boy pants, woman-up and ask for advice, not from anyone - go to the right person/people - you know who they are! https://t.co/GUs1nCvXeU
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Holes in TH17 cells release IL-1α on NLRP3 activation Certain T cells can secrete cytokines that are normally part of the innate immune system, as researchers from the Leibniz-HKI and an international research team discovered. https://t.co/lLHD66D3RP https://t.co/cym7SGD2WX

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Free great handout on DRESS - Drug Reaction With Eosinophilia and Systemic Symptoms. May affect adults or children; usually 2 to 8 weeks after beginning a medication. ~1 in 1000 taking specific drugs get DRESS. Allopurinol is a common cause https://t.co/X8lHtGVunC https://t.co/OjCzUXWJcz

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anti-mitochondrial antibodies (AMA) in were assayed in 404 #RA patients & found to positive in 14-26%. Importantly AMA Abs were associated with erosive disease (p<0.05) and interstitial lung disease (p<0.01), independent of CCP or RF https://t.co/ZcrOYr0cWX https://t.co/KvZ3N5IiCB

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10 best US jobs in2023, half are medical 1 Software developer 2 Nurse practioner 3 Medical/health serv manager 4 Physician asst 5 Information security analyst 6 Physical therapist 7 Financial manager 8 IT Manager 9 Web developer 10 Dentist https://t.co/nL5yuorzTH https://t.co/4mYspRCZX0

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Cannabis Use for Pain is Common In states with legalized medical cannabis use, 3 in 10 persons are using cannabis to manage their pain. https://t.co/XUt1E7GcQN https://t.co/4l6vYKUOQs

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Treatment Considerations in Axial Spondyloarthritis https://t.co/GRQfk4B4QN https://t.co/xX5AYAD90c

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2022 Memorium Sadly, too many of our rheumatology colleagues passed on in 2022. Here is an (incomplete) list of notable brethren, mentors, do-gooders and great rheumatologists. https://t.co/wtr4ablgUm https://t.co/xPpgnrEQWz

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2022 Rheumatology Year in Review Dr. Jack Cush reviews the best of 2022 in Rheumatology - highlights on new drug indications, breakthrough lupus therapies, new biosimilars and the multivitamin letdown. https://t.co/6r6W95moyr https://t.co/PNlMDId7qX

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AutoAb analysis of 140 systemic sclerosis shows low sensitivity (<33%), high specificity (>88%). Scl-70+ signif assoc w sine scleroderma, digital ulcers, Raynauds as 1st onset sign. SSc-ILD more common Scl-70 and PAH with CENP A/B Abs https://t.co/1zvkte4drJ https://t.co/FaSmshUvhY

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PsABiostudy followed PsA pts starting TNFi vs ustekinumab x12 mos showing equivalent durability at 1 yr (72% vs 71%). cDAPSA LDA was seen in 56% UST vs 67% TNFi (similar for MDA (34% vs 43%) https://t.co/briK7itZtL https://t.co/Rq1SXA7s1s

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UK Database 1,955 breakthrough COVID-19 infxs in 54,576 #gout pts compared to 52,468 w/o gout saw more in gout (adj HR 1.24), also w/ more #COVID hospitalizations (adj HR 1.30) & death (1.36), more so in women. Same for unvaccinated https://t.co/596KvupZxi https://t.co/BJJguQBdin

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