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Methotrexate to Prevent RA, Clear as Mud

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Intervention in individuals predisposed to develop rheumatoid arthritis (RA), with a holy grail of prevention of RA, has long been a hot topic.

Ozempic will change rheumatology

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Ozempic is everywhere. Even all the way in Australia, where we have highly constrained supply that makes headlines and substantial limits on direct-to-consumer advertising, somehow I know the jingle from the American ad for Ozempic.

Shifting Trends in Initial RA Treatment Approaches

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A recent study by Sparks et al (Abstract #0509) reveals evolving trends in disease-modifying antirheumat

Long Covid Defined

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The National Academy of Medicine and New England Journal of Medicine have published a comprehensive definition of "long COVID".

RIP to Glucocorticoids in GPA

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For many years glucocorticoids were the mainstay of our treatment of granulomatosis with polyangiitis (GPA). The paradigm shifted with cyclophosphamide and then again with rituximab, and we used less steroids, but we still used lots.

Say Goodbye to Methotrexate in PMR?

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For decades, glucocorticoids (GCs) have formed the backbone of polymyalgia rheumatica (PMR) management.

Genes Linking Rheumatoid Arthritis and Osteoporosis

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Rheumatoid arthritis is a common disease affecting an estimated 17 million people worldwide. The disease is caused by immune cells attacking the joints and can result in pain, swelling, and damage to the cartilage and bone.

Is Your Practice Up to Date? New Guidelines for SLE Nephritis

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Randomized controlled trials (RCTs) drive guidelines; guidelines drive clinical practice.

RA-ILD in the Spotlight at ACR 2024

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Over the past 5 years, there has been growing interest in RA-ILD due to its relative prevalence and severity. This seems to be one of the few RA outcomes not improving much, even with the advent of expanded treatment options. There is also a shocking lack of trial data.

A Keto Diet for Autoimmune Disorders?

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Scientists have long suspected the keto diet might be able to calm an overactive immune system and help some people with diseases like multiple sclerosis.

Now, they have reason to believe it could be true.

Novel and Emerging Therapies in Psoriatic Arthritis

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Recent advancements in targeted therapies, including selective inhibitors of key inflammatory pathways, offer promising outcomes for patients with active psoriatic arthritis (PsA). At ACR 2024, there have been further developments in novel therapies in PsA.

ACR 2024 - Day 3 Report

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Highlights from Day 3 at ACR24 included the plenary session presentation on Nipocalimab (previously reviewed), but the big highlight was the Lupus Nephritis guideline recommendations.

2024 Updated ACR Guideline for the Diagnosis and Treatment of Lupus Nephritis

#ACR Best 2024 - Day 4

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Although the last day of ACR Convergence 2024 was but a half day - it was chock full of gems, many coming from the late breaking abstracts presented today.  As chosen by the RheumNow faculty, here are some highlight presentations you need to know about.

Beyond the Needle: Redefining the Assessment of Lupus Nephritis

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Lupus nephritis is one of the most silent and severe manifestations of systemic lupus erythematosus (SLE). When not captured early, patients are at high risk of progressing to end-stage renal disease, which would require dialysis or transplantation.

Maximizing DMARDs to Strive for Steroid-Free Remission in RA

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In 1950, three scientists were awarded the Nobel Prize for their groundbreaking discovery of steroids, heralded at the time as a "miracle cure" for rheumatoid arthritis (RA).

ORAL Surveillance - Is Statin Use the Problem/Solution?

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The findings from ORAL Surveillance Study have been a dominant conversation at recent ACR Convergence, with the seminal findings and subsequent analyses a target of debate.

COVID-19 and Long-Term Risk of Autoimmune and Autoinflammatory Disorders

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A Korean population based study found that people infected with COVID-19, especially severe COVID-19, had an increased risk of autoimmune and autoinflammatory connective tissue disorders.

What Lies Beneath: Understanding Nailfold Capillaroscopy

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Capillaroscopy is a non-invasive imaging technique used for the in vivo assessment of the microcirculation.

ACR24 Preview Podcast (11.15.2024)

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ACR 2024 starts tomorrow. Here are a few previews of abstracts to be presented, along with my recommendations of sessions you don’t want to miss.

Previews:

#ACR 2024 BEST Abstracts from Day 1

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The RheumNow faculty have parked at the plenaries, trafficked the posters and have been finding the best the meeting offers on the first day at ACR 2024 in Washington, DC.  Here are some of the best abstracts from Saturday Nov. 16th.