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Sleep asleep

Sleep Quality & Psoriatic Arthritis

d Olga Petryna, MD

For people living with psoriatic arthritis (PsA), the comfort of a good night's sleep may feel out of reach for many.

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Methotrexate + pegloticase increases response rates in gout

d Bella Mehta, MBBS, MS

In abstract 0001 presented at ACR22 Convergence, researchers presented 12-month data from a randomized double-blind placebo-controlled trial of pegloticase with or without MTX.

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lupus SLE

Dual target blockade may be better than one in SLE

d Md Yuzaiful Md Yusof, MRCP(UK), PhD

Inhibition of B-cell Activating Factor (BAFF) has revolutionised the treatment of patients with systemic lupus erythematosus. However, outcomes of therapies within the same class (i.e. BAFF-inhibitor) when evaluated in randomised controlled trials have been inconsistent.

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Best of

ACR Best Abstracts - Day 3

d Jack Cush, MD

The last day was jammed with important reports and research including the late breaking abstracts. 



 

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tumeric

The spicy topic of turmeric in rheumatoid arthritis

d David Liew, FRACP

Curcumin, the active constituent of turmeric extract, has increasingly been promoted as a potential rheumatoid arthritis therapy, but data presented at ACR22 suggests that even in ideal situations, it is unable to do any better than placebo in replacing conventional RA therapies.

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The complexity of opioid use in spondyloarthritis

d Robert Chao, MD

A few things we know about opioids: use is common; it’s not efficacious in the treatment of spondyloarthritis; and, there is an opioid epidemic and its users are stigmatized. Abstract 0402 is a retrospective study that looked at patients with psoriatic arthritis or ankylosing spondylitis in the FORWARD databank. It sheds new light and leaves us with some food for thought

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Does BASDAI work for women? In Abstract 0406 S. Maguire et al sought to understand if BASDAI and BASFI captured disease activity and quality of life in female axSpA patients. Read more from Dr. Rachel Tate ( @uptoTate ) #ACR22 https://t.co/yWzdRMPgpp https://t.co/YrMsAYbAWN

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Dr. John Cush RheumNow ( View Tweet)
ACR Best Abstracts - Day 3 The last day was jammed with important reports and research including the late breaking abstracts. These were some of our favorites. #ACR22 https://t.co/vUrxBTF3Wj https://t.co/QKpTjyFfxt

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Dr. John Cush RheumNow ( View Tweet)
#ACR22 final plenary session 10 week study outcomes of Philly vs Placebo to be reported #rheumpix @RheumNow https://t.co/BradH2Ty70
Eric Dein ericdeinmd ( View Tweet)
Can you put a bit of morphine intraarticularly inside an osteoarthritic knee and make it better? Cute idea, no bingo. I get that we're chasing better symptomatic solutions, but... Don't do this. ABST1833 #ACR22 @RheumNow https://t.co/pvsGx93eoU
David Liew drdavidliew ( View Tweet)
Erosive OA: have we got anything disease-modifying? Not much right now (read: nothing) Denosumab 60mg q3mo for bone remodelling? radiographic change, erosive jt development: real improvement pain, function: zip at 48w, some at 96w? Def worth more study! ABSTL05 #ACR22 @RheumNow https://t.co/Yo9u5BlYYJ
David Liew drdavidliew ( View Tweet)
PAN relapse risk ⬆️ in: 👉severe GI involvement 🧓>65y/o 👉skin necrotic lesions PAN ⬆️ mortality wt: 👉AKI 🧓>65y/o 👉necrotic purpura 👉secondary PAN Abst#2232 @RheumNow #ACR22

Patricia Harkins DrTrishHarkins ( View Tweet)

Abstr #2196- COVID-19 outcomes in IMID dx in large US Hospital vs Pre-Omicron - ↑ COVID + rate (21.9% vs 7.9%) - ↓ hospitalized (0.8% vs 3%) & death (1.8% vs 4.5%) - Hospitalization & death > gen pop both pd. -Age & comorbidities assoc w worse outcomes @RheumNow #ACR22

Akhil Sood MD AkhilSoodMD ( View Tweet)

Biosimilar multi-switching in RA: is it an issue? Switching back & forth between originator & biosimilar should create ideal conditions for immunogenicity or anti-drug Ab This study: multi-switching vs no switching No issues at all Switch away in RA! ABST1589 #ACR22 @RheumNow https://t.co/pGBF2BHp7y
David Liew drdavidliew ( View Tweet)
We want to see how you are taking in #ACR22! Share your favorite pictures from ACR on Twitter and tag #RheumPix and #ACR22 and we'll re-tweet our favorite ones! https://t.co/ygfYol5Z3f
Dr. John Cush RheumNow ( View Tweet)
ACR2022 Topic Panels https://t.co/5gMfFS8maR

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Dr. John Cush RheumNow ( View Tweet)

@rheumecraig @RheumNow Absolutely. In this #ACR22 study, they did exclude anyone with deranged LFTs from this study and yet still two people in the turmeric arm got LFT derangement (vs zero in placebo). Sadly I don't think the turmeric salespeople are watching the LFTs.

David Liew drdavidliew ( View Tweet)

Abstr #2191 studies impact of maternal SLE on outcomes of children Maternal SLE assoc w/ ↑ odds of - SLE of children (HR 98.48, 95%CI:63.39-152.98) - other AutoImm dx (HR 1.26, 1.02-1.57) (Hashimoto, JRA, IBD) - Neurodev dx (1.35, 95%CI:1.15-1.57) (ADHD) @RheumNow #ACR22

Akhil Sood MD AkhilSoodMD ( View Tweet)

UPA tx in prior TNFi tx PsA pts demonstrated consistent efficacy compared to the overall population in SELECT-PsA 2, regardless of number of prior anti-TNF therapies. Abs 2146 #ACR22 @RheumNow https://t.co/xnN4nvZ934 https://t.co/3S6ZzPvqVe

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Dr. Rachel Tate uptoTate ( View Tweet)
How to adjust for GC correction when dose >/= 7.5mg/d using FRAX? Calculate FRAX then 🦴For MOF risk multiply by 1.15 🦴HF risk multiply by 1.2 = adjusted risk (%) (Adjustment of FRAX accdg to GC dose from Kanis et al., OI 2011) #ACR22 @RheumNow @Rheumarhyme @PhRheumaJr https://t.co/qap1fFhF0h
sheila RHEUMarampa ( View Tweet)

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