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Hope for Biologic Treatment of Hidradenitis Suppurativa
A meta-analysis of trials using biologics [adalimumab (ADA), ustekinumab (UST) and secukinumab (SEC)] in the the management of hidradenitis suppurativa (HS) suggests promising results, but more controlled, rigorous studies are needed.
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Herpes Zoster with JAK Inhibitors
JAK inhibitors are approved for several immune-mediated inflammatory diseases and carry a higher than usual risk of herpes zoster in certain conditions like rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and ulcerative colitis.
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Women at high risk of fracture remain untreated for osteoporosis
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EurekAlert!
An estimated 100,000 to 120,000 fragility fractures occur annually in the Netherlands, the equivalent of at least 11 broken bones per hour.
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Studies in 76 systemic sclerosis (SSc) pts (& animal models of SSc) show fibroblast A20 (enzyme) is downregulated and promotes fibrosis in SSc; but is repressed by DREAM, an A20 negative transcriptional regulator. https://t.co/30PuO4XRuq https://t.co/VJuAJHGbut
Dr. John Cush RheumNow ( View Tweet)
Join us at RheumNow Live this March!
Dr. Janet Pope ( @janetbirdnope) will be back to discuss decisive therapeutics in RA.
https://t.co/0IkJsGpH6s https://t.co/TwM6AAW97X
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US population mortality rates compared dermatomyositis (DM) vs polymyositis (PM) in 1981 (12,249) & 2020 (23,608). Downward trend in DM/PM mortality (<7%); plus PM/DM was 2X more likely to be one of mult causes, instead of, sole cause of death. https://t.co/9KZKr8JxUE https://t.co/7acK0eHVku
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Systematic review of MRI confirm degenerative meniscus tears compared arthroscopic meniscectomy (APM) vs non-surgical or sham Rx. Results: 10 trials, 605 patients showed at 24 mos F/U, no advantage in Function or QOL favoring APM - rec conservative Rx
https://t.co/4CwicQ9Jac https://t.co/3IrSRkNgqp
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How do you treat latent TB? This and more on last week's RheumNow podcast.
https://t.co/4gUXFUDTFM https://t.co/TgT6ZyewZJ
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Can something as simple as a cup of coffee with milk have an anti-inflammatory effect in humans?
Apparently so, according to a new study. A combination of proteins and antioxidants doubles the anti-inflammatory properties.
https://t.co/As8lhxnifp https://t.co/eZKD8Y6oTx
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Amgen launched its adalimumab biosimilar - Amjevita ( FDA approved in 2016), has 2 different discounts— 55% or 5% below Humira's (list $6,922/mo). Another report says Amjevita 40mg given q 2wk will cost $40,497 - $85,494 annually https://t.co/iGtJUa991N https://t.co/PTPTUskUaa
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1st there was combined Rheum-Derm or Rheum-Pulm clinics. Medscape reports new Rheum-Cardiology clinics at Cleveland Clinic, NYU, Brigham, Stanford. Useful in research, managing Rheum pts a) at hi CV risk, B) having procedures/surgery, c) risk reduction https://t.co/9AqujArSMT https://t.co/3ZVORt9gK9
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FDA has approved the 1st BTK (Bruton’s tyrosine kinase) inhibitor (Jaypirca™ or pirtobrutinib) for adults with refractory mantle cell lymphoma. BTK inhibitors are also being developed for use in MS, RA, SLE, pemphigus & more https://t.co/gDHbcDpNnT https://t.co/oL0nldQ1fN
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Last day for early bird pricing!
https://t.co/KwQnDC4Pdz
RheumNow Live is a 1.5-day long meeting that offers pre-learning modules, shorter, concise lectures with clinical context and audience input, more discussion time, and sessions that are relaxed and comprehensive. https://t.co/W4mqIyhgRS
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Have you listened to last week's RheumNow podcast?
Dr. Cush answers the question--is there such a thing as dry synovitis?
https://t.co/Um0JhCfRDv https://t.co/rXOGWOEnlr
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Pathogenic Impact of microRNA Cotargeting in Lupus
A group of researchers from the Graduate School of Medicine at Nagoya University in Japan have discovered the impact of microRNA (miRNA) on inflammation in lupus in mice.
https://t.co/j0TRgIaam6 https://t.co/HNJbsTfT7c
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Study of 58 pediatric patients with Kikuchi-Fujimoto disease saw 15 (26%) with Macrophage Activation Syndr. KFD-MAS+ pts had signif. more skin rash (27%), Steroid Rx(80%), Dz recurrence (33%), lower cell counts (WBC, plt, lymphs) & higher LDH. https://t.co/GINlAJlEHi https://t.co/idhuaAo9T6
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197 ANCA assoc Vasculitis pts in RAVE - treated w/ RTX or CTX, thenAZA. 18/22 severe infections occurred within 6 months. Predictors of severe infx included higher baseline CD19+B cells & PJP prophylaxis w/ TMP/SMX (both groups Rx RTX or CYC/AZA) https://t.co/YhNDCdJuof https://t.co/Fg8AOLtYbI
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Advancing Telehealth in Rheumatology
https://t.co/XZTkGQMImc https://t.co/QJjXzjAx5Q
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Rheumatic Disease - IBD Overlap
Nearly one in 10 patients with IBD also have rheumatologic disorders, meaning that specialists have to talk to each other to develop a treatment plan that works for both conditions, a researcher suggested.
https://t.co/s3u9q8Sw9Y https://t.co/RjFyEcm6FA
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AI Passes U.S. Medical Licensing Exam
Two artificial intelligence (AI) programs -- including ChatGPT -- have passed the U.S. Medical Licensing Examination (USMLE), according to two recent papers.
https://t.co/E5GEWrJR00 https://t.co/nd9PrLVn4U
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