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Abstr #2192 risk of serious infxn in newborns of mothers on TNFi by placental transfer
- % serious infection in TNFi in high vs low placental transfer (2.1% vs 1.6%)
- HR (high vs low) 0.98 (95% CI 0.36-2.61)
- No significant difference in risk of serious infxn
@RheumNow #ACR22 https://t.co/7Lfpf7PERu
Akhil Sood MD AkhilSoodMD ( View Tweet)
Which patients with IIM are high risk for #cancer?
Abstract #0002 #ACR22 @RheumNow #ACRBest
📍Dermatomyositis
📍Anti-TIF-gamma, anti-NXP2
📍Age > 40y at dz onset
📍Dysphagia
📍Cutaneous necrosis
📍Persistent high dz despite immunosuppressive tx
Catherine Sims, MD DrCassySims ( View Tweet)
Which is better for CV risk in RA:
triple therapy DMARDs or TNFi?
TARGET study
n=159 using PET/CT surrogate (endpoint responsiveness👀)
- either led to benefit
- both equally good
- benefit *not* linked to change in DAS28
A direct CV effect of RA Rx?
ABST2215 #ACR22 @RheumNow https://t.co/4FPvSbfGsD
David Liew drdavidliew ( View Tweet)
Vaccination +/- prior Covid-19, and with either mRNA or vectored DNA vaccines were not associated with AIRD flares. Negative association 21-days after 1st Covid-19 vaccination and no association after 2nd or 3rd doses. Nakafero G Abs#2194 https://t.co/vA8cMNQGkr #ACR22 @RheumNow https://t.co/SZnXejnmYt
Dr. Antoni Chan synovialjoints ( View Tweet)
Singh @NamrataRheum et al. Frailty in patients treated bDMARD/tsDMARD assoc serious infections aHR 1.34, any infection aHR 1.18, hospitalisation aHR 1.34 (all relative non-frail). @RheumNow #ACR22 Abstr#2218 https://t.co/ONsTBq8ehB https://t.co/iTVANh5flk
Richard Conway RichardPAConway ( View Tweet)
Thieves Market #ACR22
Ulcerative palatal lesions, non-spec bx
+ANA 1:320 w other neg Abs
Empiric steroids for presumed vasculitis
New cavitary lung lesion. Pathology showed vasculitis
Dacrocystitis w lobulated paranasal mass
Dx: Extra nodal NK/T-cell lymphoma
Fatal case
@RheumNow https://t.co/TlDy9GfW7N
Eric Dein ericdeinmd ( View Tweet)
Flatman et al. Risk of infections in children with third trimester TNFi use, high vs low (CTZ, ETN) placental transfer. No difference but wide CIs, aHR 0.98 (0.36, 2.61) @RheumNow #ACR22 Abstr#2192 https://t.co/350UxX9bkL https://t.co/29uOtek8w7
Richard Conway RichardPAConway ( View Tweet)
💤cognitive behavioural therapy 2 hours/wk for 6 wks for insomnia improves RA PROs at 26 wks
Insomnia Severity Index -9.8
RAID -1.4
PGA -13
Small sample size
wk6 trend improvement sleep efficiency 89% vs84% p=0.07 but not wk26
https://t.co/rpKdtbREYs Abs#2188 #ACR22 @RheumNow https://t.co/kEBcPAdIKW
Aurelie Najm AurelieRheumo ( View Tweet)
Interesting Abs 1997 finds butyrate supplementation in RA assoc'd w/changes in human gut microbiota composition and in peripheral Treg abundance and markers of Treg activation. More data needed to determine clinical/dz activity relevence. #ACR22 @RheumNow https://t.co/tQocYUU0Er
Dr. Rachel Tate uptoTate ( View Tweet)
#PregnantWoman with #sle - n = 873
Highest overall adverse events in Preexisting HTN
complicated by race
We have a Modifiable risk factor - HTN to work closely
abst#2107 @rheumnow #ACR22 #ACRBest
https://t.co/EC8c7Dzrvs https://t.co/Jydz0uo1bv
Bella Mehta bella_mehta ( View Tweet)
Interosseous tendon inflammation (ITI) the new predictor of clinical RA in pts w/ clinically suspect arthralgia.
600+ pts Hands MRI
Present 10% pts w/ CSA, 1% symptom free 27% ACPA+ 7% ACPA-
HR 4.5 dvlpmt of clinical RA
https://t.co/BmRF1tLFx9
Abs#2204 #ACR22 @RheumNow https://t.co/F8DUxiI2dh
Aurelie Najm AurelieRheumo ( View Tweet)
Thieves Market #ACR22
Amoebic arthritis - is it rare?
Case from Indonesia
After the case, found it in 3 other synovial fluids!
Rx with surgery, metronidazole - later rx for post-ifn arthritis and gout
@RheumNow https://t.co/oi8PqtTTyc
Eric Dein ericdeinmd ( View Tweet)
Severe subtype of #sJIA HLADRB1*15:01 known to be associated with adverse drug reactions to biologics.
prospective cohort - 65pts.
- Anakinra effective irrespective of HLADRB1*15:01
- No difference in eosinophilia
- Recommend not to wait to start tx
@rheumnow #ACR22 abst#L12 https://t.co/LX5lMJOKRf
Bella Mehta bella_mehta ( View Tweet)
Alert 🚨
New imaging technology
MSOT = combination of US and photo acoustic imaging
Detects metabolites in enthesis and synovitis
🫱🏼>Hb and O2 saturation correlate w/ Doppler+
🫱🏼>Hb & collagen correlate w/ calcifications
https://t.co/X18fGFVh5L
Abs#2205 #ACR22 @RheumNow https://t.co/84BU5YUrCz
Aurelie Najm AurelieRheumo ( View Tweet)
RA really does still impact employment outcomes for many, despite T2T.
@earlyarthritis🇨🇦 data in working age people show many back in the game in the first year, but not many more after that.
Plenty more to do to get all our pts back to their best!
ABST1967 #ACR22 @RheumNow https://t.co/isD1rgkFoH
David Liew drdavidliew ( View Tweet)
SURPASS was a head-to-head study comparing SEC vs ADA biosimilar (SDZ-ADL) in r-axSpA on spinal radio progression:
Results showed no significant diff in spinal radio progression bet. the 2 grps.
Biosimilars remain tx options for r-axSpA.
#ACR22 @RheumNow ABST#L15
sheila RHEUMarampa ( View Tweet)
Foot involvement in RA not included in disease activity scores. This abstract showed that patients w/ active foot involvement have higher scores anyway (driven by physician & patient global) but examining feet would have only changed management in 3.1%.
@RheumNow ABST0265 #ACR22 https://t.co/ckuB8R4ZTF
Julian Segan JulianSegan ( View Tweet)
Response to ULT
in
Hyperuricaemia +non episodic foot pain not meeting criteria for gout classification predicted by
🔥US findings of
👉double contour sign
👉tophus
Abst 1828 #ACR22 @FloodRachael @RheumNow https://t.co/ATzEgFOWU0
Patricia Harkins DrTrishHarkins ( View Tweet)
PNEUMOVAS study results suggest AAV pts on RTX showed improved S. Pneumoniae ab response with double dose of PCV13 at day 0 and day 7 followed by a single dose of PPV23 at M5. More data needed on this updated, clinical strategy. Abs L16 #ACR22 @RheumNow https://t.co/m71VQMGZ68
Dr. Rachel Tate uptoTate ( View Tweet)
Polymyalgia rheumatica: more than just steroids at #ACR22
After decades of having little else proven apart from glucocorticosteroids with which to treat PMR, evidence for steroid-sparing options has grown in recent years.
https://t.co/CjMzEqRan8 https://t.co/5UixhVemqY
Links:
Dr. John Cush RheumNow ( View Tweet)