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Rheum Believe it Or Not (1.13.2023)
Dr. Jack Cush reviews the notable standouts in the news since the 1st of January. Surprising reports on ferritin, alcohol benefits, cannabis for pain and a lower dementia risk with hydroxychloroquine. Here are the links below.
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173 PsA pts enrolled to start ustekinumab: half on MTX and half on PBO. At week 24 there was no difference in DAS28 between groups (2.9 vs 3.1); then Ustekinumab plus placebo was non-inferior to ustekinumab plus methotrexate https://t.co/AygtawIZsZ https://t.co/YLGp5lMWT9
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ACP Guidelines on Fracture Prevention in at-risk Adults
The American College of Physicians (ACP) has updated its 2017 recommendations on pharmacologic treatment of primary osteoporosis or low bone mass to prevent fractures in adults.
https://t.co/e7qaNCXUnx https://t.co/yys4MXMyOd
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Free great handout on DRESS - Drug Reaction With Eosinophilia and Systemic Symptoms. May affect adults or children; usually 2 to 8 weeks after beginning a medication. ~1 in 1000 taking specific drugs get DRESS. Allopurinol is a common cause https://t.co/gTW8D3raHV https://t.co/aQbnFS3rNR
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anti-mitochondrial antibodies (AMA) in were assayed in 404 #RA patients & found to positive in 14-26%. Importantly AMA Abs were associated with erosive disease (p<0.05) and interstitial lung disease (p<0.01), independent of CCP or RF https://t.co/TW2xsa1igt https://t.co/jr1ltgGmdF
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AutoAb analysis of 140 systemic sclerosis shows low sensitivity (<33%), high specificity (>88%). Scl-70+ signif assoc w sine scleroderma, digital ulcers, Raynauds as 1st onset sign. SSc-ILD more common Scl-70 and PAH with CENP A/B Abs https://t.co/ZQksWVauMZ https://t.co/RKSWOItdxu
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Evidence based Latin American Guidelines of clinical practice on prevention, diagnosis, management and treatment of glucocorticoid induced osteoporosis. A 2022 update https://t.co/CmYnENB60W https://t.co/Qm5hR1fCx6
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Neutrophil-to-lymphocyte ratio (NLR) was studied in 205 Idiopathic pulmonary fibrosis (IPF) pts - NLR correlated with lung function, & outcomes - NLR >= 2.9 was associated with a significant 2 fold increased risk of mortality https://t.co/FwnfrVW29M https://t.co/BIX8e3svJB
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Hosp study of 2809 admissions, found 1+adverse events (AE) in 24%. Among 978 AE, 23% (222) were preventable; 32% (316) serious. Preventable AE occurred in 1/15 admissions (serious 1/100). Drug AE were most common (39%) https://t.co/YKaYgmRbLN
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Dr. John Cush RheumNow ( View Tweet)
Join us on 3/18 and 3/19 in Dallas, Texas or virtually for RheumNow Live!
RheumNow Live is unlike any meeting you've ever attended. Here's why:
-Inspired Education
-The Audience Matters
-Never Seen Before
https://t.co/qKoBckRNK1 https://t.co/2tyLsxV0L7
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Bimekizumab in Active Psoriatic Arthritis - BE COMPLETE study
https://t.co/S4V3rf4cDc https://t.co/XyZMp1CrsX
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473 RA pts from the BeSt study were analyzed. for correlation betw joint
cumulative inflammation and radiographic damage. Cumulative jt swelling was signif correlated w/ future xray damage/erosions, less so for tender only jts https://t.co/DQ06VYBDxm https://t.co/PfRWCcti8T
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Case crossover study of 508 #RA pts starting biologics (75% on steroids) showed significantly higher rates of RA flares if steroid doses taken down ≤2.5 mg/d (vs >2.5 mg/d) - adj OR of 1.37 to 1.45 https://t.co/sjkw6LJI0W https://t.co/k0jgnui5CH
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Degeneration seen in #OA may be related to cartilage tissue stiffening with the repression of a key longevity protein α-Klotho brought about by epigenetic changes. Downregulated Klotho gene expression accelerated chondrocyte senescence https://t.co/HBLeLIlmJG https://t.co/T7d6EodDYN
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ACR GCA classification criteria tested in 676 patients suspected GCA (+US) - 276 dx w/ GCA; 400 not. Sensitivity was 87%, specificity 70%; 35 (13%) GCA pts did not meet criteria. & 119 non-GCA (30%) had ≥6 points (most PMR) https://t.co/bTrj83yM7l https://t.co/9iA8LbX6vB
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Rheumatologists: What do you devote your weekends to?
Dr. John Cush RheumNow ( View Tweet)
2022 ACR Classification Criteria for GCA: (must be >50yrs) 6+ points needed for #GCA
AM stiff should/neck +2
Visual loss +3
Jaw Claud +2
Temp HA +2
Scalp tender +2
Hi ESR/CRP +3
+Bx or US +5
axillary +2
+PEG Aorta +2
https://t.co/ZtVlYhpwru https://t.co/L1sv3L9p37
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Register for RheumNow Live today and qualify for early bird pricing.
Among our 24 speakers, Drs. Coates, Ruderman, and Champers will lead a session on the Modern Management of Psoriatic Arthritis.
https://t.co/tiJssRdzAw https://t.co/Rar27hRahf
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Population data on incidence of #RA from Northern Savo, Finland, 46 new RA cases in 2020; incidence seropos RA was 22.3 per 100K. Incidence did not differ by gender but decreased w/ age < 55 years, p = 0.003 (change in risk factors?) https://t.co/QxMwKh7wIU
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Ferritin may be more than biomarker in Stills, etc - may contribute directly to pathogenesis. Ferritin causes PMN activation & neutrophil extracellular traps (NETs). Could this be targeted therapeutically? https://t.co/42KeTbVsQb https://t.co/imLipzmf4R
Dr. John Cush RheumNow ( View Tweet)