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Does diet & exercise work for knee pain in #osteoarthritis? Pragmatic trial in 3 community sites. 823 RCT, 80% completed -control was education &meetings vs diet&exercise;more intense. 101kg, 77% F, age 65. Diff modest-favoured diet & exercise-works a bit #ACR22 @RheumNow #1675 https://t.co/akjEjVprJl
Janet Pope Janetbirdope ( View Tweet)
Pain in #psoriaticarthritis might not be all inflammatory..
In this study presented by Dr F Sunzini:
👉PsA pts w/⬆️FM scores had⬆️functional brain connectivity bet mid-post IC & thalamus, phgyrus & PFC
..so consider nociplastic pain too & adjust mgt
#ACR22 @RheumNow ABST#2256 https://t.co/suCAvx0pD5
sheila RHEUMarampa ( View Tweet)
Plenary session III:
Intensive diet and exercise program in overweight/obese pts with knee OA showed significant reduction in weight, pain and function, greater walk distance and quality of life.
Abs#1675 @RheumNow #ACR22 https://t.co/vstfJahLQV
Robert B Chao, MD doctorRBC ( View Tweet)
Bruce et al. Rheumatic disease onset/flare with ICI assoc good tumour response in melanoma. OR = 14.151 @RheumNow #ACR22 Abstr#1668 https://t.co/870ODwva5n https://t.co/bcneKZbeC4
Richard Conway RichardPAConway ( View Tweet)
Bass et al. Treatment ICI-arthritis. Tricky one. MTX alone assoc longer time to cancer progression and to arthritis control compared to combination with bDMARD. Thoughts @drdavidliew ? @RheumNow #ACR22 Abstr#1669 https://t.co/8KH8RZzcaZ https://t.co/DtpA8s4PLy
Richard Conway RichardPAConway ( View Tweet)
Are your SpA pts planning on conceiving? Be careful with NSAID use
French study found age and NSAID use associated with longer time-to-conception.
Factors not associated: smoking, BASDAI score, DMARD use
#ACRBest Abs#1673 @RheumNow #ACR22 https://t.co/D63XTY7IB8
Robert B Chao, MD doctorRBC ( View Tweet)
Ab1673 #ACR22: Time-to-Conception (T2C) in SpA
Prosp, observ
88F, 56 pregnancy
Subfertility in 45% F, T2C 16 mos
Risks: age, NSAID
Rx: NSAIDs (26%), steroids (9%), csDMARD (14%), biol (69%)
No control grp - Is it cause or correlate?
2020 Repro G/L rec d/c NSAID
@RheumNow #ACRBest https://t.co/e51XjhyH9u
Eric Dein ericdeinmd ( View Tweet)
☝️Treatment is the 3rd reason why we need to order a BL HRCT in pts with ILD; "We can't treat SSc-ILD if we are not able to detect SSc-ILD" - Dr. Elana Bernstein
#ACR @RheumNow #rheumatology https://t.co/ooZVSbt3Xf
sheila RHEUMarampa ( View Tweet)
Peresolimab humanized IgG1 mab
➢ stimulates PD-1 & physiological immune inhibitory pathways
➢ In RA phase 2 study, superior to placebo at Week 12 DAS28/CDAI
➢ safety events were similar between treatment groups
Emery P #L03 https://t.co/4Jd79CW5RA #ACR22 #ACRBest @RheumNow https://t.co/PSuLQgjYuz
Dr. Antoni Chan synovialjoints ( View Tweet)
BE OPTIMAL Study - Bimekizumab (IL-17A and IL-17F inhibitor) for treatment of PsA.
Similar ACR 50 (~50%) response rates of Bimekizumab, adalimumab, and placebo (switched to BKZ at wk 16).
~60% PASI100 in BKZ
#ACRBest Abs#L02 @RheumNow #ACR22 https://t.co/W2B2kyju9F
Robert B Chao, MD doctorRBC ( View Tweet)
Hamroun et al. Preconceptual NSAID use assoc impaired fertility in SpA, HR 3.01 for time-to-conception @RheumNow #ACR22 Abstr#1673 https://t.co/jresR9MfXF https://t.co/flyfJob9un
Richard Conway RichardPAConway ( View Tweet)
Congratulations @RheumNow @rheum_cat @CreakyJoints 🎉 #ACR22 https://t.co/P7iLUPnt0p
Catherine Sims, MD DrCassySims ( View Tweet)
Ab1674 #ACR22 HCQ in pregnancy is SAFE and Standard of Care!
In Utero Exposure to HCQ does NOT ass w/ ocular toxicity: OCTs 5 yrs after birth 👀
PATCH study of HCQ to reduce CHB in pregnancy
18% CHB (historical) -> 7% treated risk
OCT: retinal thickness nml at 5 yrs
@RheumNow
Eric Dein ericdeinmd ( View Tweet)
#CurbsideConsult. What would you do? 45 yo female with dSSc and ILD, had been on stable MMF 1500 mg bid. she had increased SOB, new dry cough, hand pain, stiffness.Exam noted synovitis, Labs: ESR 76, Echo RSVP 25 mmHg, HRCT increased ILD compared to a year ago. #ACR22 @rheumnow
TheDaoIndex KDAO2011 ( View Tweet)
Are TNFi or IL-6Ri safe in rheumatic irAEs from ICI Rx?
Multiple big US centers retrospective:
TNFi, IL-6Ri vs MTX
p>0.05, but may be approx 2x risk of cancer progression
Has made me more cautious about TNFi, IL-6Ri - use MTX when you can
Lovely work! ABST1669 #ACR22 @RheumNow https://t.co/cfAT1pQZ7I
David Liew drdavidliew ( View Tweet)
This is how Dr. Berstein manages SSc-ILD #ACR22 @rheumnow #CurbsideConsult https://t.co/vP7m0WpdK6
TheDaoIndex KDAO2011 ( View Tweet)
Abdel-Wahab et al. TCZ in combo with ipilimumab/nivolumab. Very preliminary results of what will be important trial. Appears safe and well-tolerated with no increased risk cancer progression. @RheumNow #ACR22 Abstr#1670 https://t.co/uPBnHJ9BRH
Richard Conway RichardPAConway ( View Tweet)
Messier et al. WE-CAN pragmatic trial of diet and exercise (vs attention control) in knee OA with high BMI. Significant improvement in pain, walk distance, SF-36 with corresponding reduction in body weight @RheumNow #ACR22 Abstr#1675 https://t.co/uSSzx4u2sp https://t.co/upnIVecRjv
Richard Conway RichardPAConway ( View Tweet)
SAPHYR results: SAR + 14 wk GC taper showed efficacy vs comparator arm in steroid refractory PMR, including clinically meaningful improvement in QoL. No new safety signals. Plenary Abs 1676 #ACR22 @RheumNow https://t.co/mHu3e9JbCp https://t.co/93kbczSTfS
Dr. Rachel Tate uptoTate ( View Tweet)
Tonight at 7pm ET! Join our RA Topic Panel with panelists: Drs. Richard Conway, Aurelie Najm, David Liew, Janet Pope, Julian Segan
@RichardPAConway @AurelieRheumo @drdavidliew @Janetbirdope @JulianSegan #ACR22
https://t.co/hIH4WghLwN https://t.co/oKQbBnMiqQ
Links:
Dr. John Cush RheumNow ( View Tweet)