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🌱Plants for joints 🌱
👉16wk
👉whole food plant based diet + Phys activity + stress Mx
👉 metabolic syndrome assoc OA hip/knee
💥 substantial ⬇️ pain + stiffness
💥⬆️ physical function
#ACR22 @RheumNow Abst 1644 https://t.co/u6UufpbrcC
Patricia Harkins DrTrishHarkins ( View Tweet)
Thanks for the love #Philly #ACR22 @RheumNow check out our coverage by logging on to https://t.co/xF1bNhZB1C! https://t.co/ncBM0icZ3c
Links:
Dr. Rachel Tate uptoTate ( View Tweet)
Retrospective cohort study 132 immune checkpoint inhibitor arthritis pts Rx with either TNFi ± MTX or IL6Ri ± MTX have a shorter time to cancer progression but faster arthritis control than patients Rx with MTX alone. Bass A Abs#1669 https://t.co/h0Nq6yd2wf #ACR22 @RheumNow https://t.co/XfXMtdbCPB
Dr. Antoni Chan synovialjoints ( View Tweet)
Wallace @BethIWallace et al. Time dependent evaluation GCs and MACE in RA. Effect of steroids in previous 6 months on MACE risk in next 6 months. Odds MACE (vs no steroid) 1.54 (1-7 days) 1.78 (8-90 days) 2.17 (>90 days) @RheumNow #ACR22 Abstr#2219 https://t.co/w4gCgjeSNa https://t.co/TQ9pufGtBD
Richard Conway RichardPAConway ( View Tweet)
Sphygmomanometer for fibromyalgia detection in rheum OPD
🔥⬆️local pain during BP testing strongly indicates presence of FMS
✅useful, easily applicable and practical screening tool
Abst#1225 #ACR22 @RheumNow
Patricia Harkins DrTrishHarkins ( View Tweet)
#FMF 2350 pts = 40% with arthritis
- Colchicine resistance in 20%
- M694V mutation carrier rate high (mutant MEFV gene)
- FMF pts with arthritis have a more severe disease course
- incidence of spondyloarthropathy was increased in FMF
#ACR22 @RheumNow abst#1830 https://t.co/uiLhjK0UjY
Bella Mehta bella_mehta ( View Tweet)
Rohmer @TerrierBen et al. 196 cases of PAN from France. 28% assoc another condition - MDS and cancer mainly. Relapse in 39% - assoc age>65, GI, skin necrosis. Death assoc age>65, AKI, secondary PAN, necrotic purpura. @RheumNow #ACR22 Abstr#2232 https://t.co/fyJY9O3Gm7
Richard Conway RichardPAConway ( View Tweet)
Tonight! Join our RA Topic Panel with panelists: Drs. Richard Conway, Aurelie Najm, David Liew, Janet Pope, Julian Segan
@RichardPAConway @AurelieRheumo @drdavidliew @Janetbirdope @JulianSegan #ACR22
https://t.co/j13W4GM56w https://t.co/fgDwPVdskC
Links:
Dr. John Cush RheumNow ( View Tweet)
RheumNow’s expanded coverage of the #ACR22 Annual meeting is sponsored in part by Novartis. All content chosen by RheumNow & its Faculty.
Dr. John Cush RheumNow ( View Tweet)
Curtis et al. Primary non-adherence to csDMARDs and b/tsDMARDs in RA/PsA/SpA. Medicare and commerically-insured patients. 20-44%! of new prescriptions not filled by 6 months. Higher for csDMARDs than b/tsDMARDs @RheumNow #ACR22 Abstr#2199 https://t.co/Pwg6GKu7Gg https://t.co/wPF0pu1UDa
Richard Conway RichardPAConway ( View Tweet)
Abstr #2192 risk of serious infxn in newborns of mothers on TNFi by placental transfer
- % serious infection in TNFi in high vs low placental transfer (2.1% vs 1.6%)
- HR (high vs low) 0.98 (95% CI 0.36-2.61)
- No significant difference in risk of serious infxn
@RheumNow #ACR22 https://t.co/7Lfpf7PERu
Akhil Sood MD AkhilSoodMD ( View Tweet)
Which patients with IIM are high risk for #cancer?
Abstract #0002 #ACR22 @RheumNow #ACRBest
📍Dermatomyositis
📍Anti-TIF-gamma, anti-NXP2
📍Age > 40y at dz onset
📍Dysphagia
📍Cutaneous necrosis
📍Persistent high dz despite immunosuppressive tx
Catherine Sims, MD DrCassySims ( View Tweet)
Which is better for CV risk in RA:
triple therapy DMARDs or TNFi?
TARGET study
n=159 using PET/CT surrogate (endpoint responsiveness👀)
- either led to benefit
- both equally good
- benefit *not* linked to change in DAS28
A direct CV effect of RA Rx?
ABST2215 #ACR22 @RheumNow https://t.co/4FPvSbfGsD
David Liew drdavidliew ( View Tweet)
Vaccination +/- prior Covid-19, and with either mRNA or vectored DNA vaccines were not associated with AIRD flares. Negative association 21-days after 1st Covid-19 vaccination and no association after 2nd or 3rd doses. Nakafero G Abs#2194 https://t.co/vA8cMNQGkr #ACR22 @RheumNow https://t.co/SZnXejnmYt
Dr. Antoni Chan synovialjoints ( View Tweet)
Singh @NamrataRheum et al. Frailty in patients treated bDMARD/tsDMARD assoc serious infections aHR 1.34, any infection aHR 1.18, hospitalisation aHR 1.34 (all relative non-frail). @RheumNow #ACR22 Abstr#2218 https://t.co/ONsTBq8ehB https://t.co/iTVANh5flk
Richard Conway RichardPAConway ( View Tweet)
Thieves Market #ACR22
Ulcerative palatal lesions, non-spec bx
+ANA 1:320 w other neg Abs
Empiric steroids for presumed vasculitis
New cavitary lung lesion. Pathology showed vasculitis
Dacrocystitis w lobulated paranasal mass
Dx: Extra nodal NK/T-cell lymphoma
Fatal case
@RheumNow https://t.co/TlDy9GfW7N
Eric Dein ericdeinmd ( View Tweet)
Flatman et al. Risk of infections in children with third trimester TNFi use, high vs low (CTZ, ETN) placental transfer. No difference but wide CIs, aHR 0.98 (0.36, 2.61) @RheumNow #ACR22 Abstr#2192 https://t.co/350UxX9bkL https://t.co/29uOtek8w7
Richard Conway RichardPAConway ( View Tweet)
💤cognitive behavioural therapy 2 hours/wk for 6 wks for insomnia improves RA PROs at 26 wks
Insomnia Severity Index -9.8
RAID -1.4
PGA -13
Small sample size
wk6 trend improvement sleep efficiency 89% vs84% p=0.07 but not wk26
https://t.co/rpKdtbREYs Abs#2188 #ACR22 @RheumNow https://t.co/kEBcPAdIKW
Aurelie Najm AurelieRheumo ( View Tweet)
Interesting Abs 1997 finds butyrate supplementation in RA assoc'd w/changes in human gut microbiota composition and in peripheral Treg abundance and markers of Treg activation. More data needed to determine clinical/dz activity relevence. #ACR22 @RheumNow https://t.co/tQocYUU0Er
Dr. Rachel Tate uptoTate ( View Tweet)
#PregnantWoman with #sle - n = 873
Highest overall adverse events in Preexisting HTN
complicated by race
We have a Modifiable risk factor - HTN to work closely
abst#2107 @rheumnow #ACR22 #ACRBest
https://t.co/EC8c7Dzrvs https://t.co/Jydz0uo1bv
Bella Mehta bella_mehta ( View Tweet)