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Study shows no progressive increase of MRI structural lesions in SI joints of health individuals with increasing age, including:
Bone marrow edema, erosions, fat lesions
Abs#2258 @RheumNow #ACR22 https://t.co/W2dkRCAPc4
Robert B Chao, MD doctorRBC ( View Tweet)
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SSc and DM/PM can cause disease related sexual dysfunction ➡️ consider pelvic floor PT
Abstract #0940 #ACR22 @RheumNow
🧘♀️8 week PT program targeting pelvic floor exercises and MSK issues impacting sexual function
🧘Women experienced sig. improved sexual function and QOL
Catherine Sims, MD DrCassySims ( View Tweet)
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Ab1677 #ACR22 by @MaxKonigMD
Chimeric autoAg T cell recepter (CATCR) reprogram T cells to selectively kill autoreactive B cells
Model CATCR for APLS via B2GPI-CATCR T-cells eliminating anti-B2GP DI B cells, dose-dependent
Model for SELECTIVE Rx in APLS/rheum disease
@RheumNow https://t.co/jMpMu10phL
Eric Dein ericdeinmd ( View Tweet)
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Very cool preclinical plenary @MaxKonigMD
Instead of CAR-T to just CD19, created CATCRs that selectively kill specific B cells (beta2 glycoprotein expressing cells)
Early days but super interesting possibilities - APS, SLE, AAV, & more?
#ACR22 @rheumnow #ACRBest Abstr#1677 https://t.co/nS3YtR6wN9
Mike Putman EBRheum ( View Tweet)
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#ACR22 highlights. #PMR May have Steroid sparing options. #tocilizumab abst#1106, #tofacitinib abst1107, #sarilumab #1676. Also previous #secukinumab ALL positive RCTs #ACRBest @RheumNow
Janet Pope Janetbirdope ( View Tweet)
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Izmirly et al. HCQ crosses placenta but no evidence ocular toxicity in children at 5 years old by OCT @RheumNow #ACR22 Abstr#1674 https://t.co/yMQzt6sU7i
Richard Conway RichardPAConway ( View Tweet)
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Chimeric autoantigen-T cell receptor (CATCR)-T cell therapies:
precision cellular therapy
selectively deplete autoreactive B cells
@MaxKonigMD in the plenary:
CATCR can take out anti-b2GPI autoAbs crucial to antiphospholipid syndrome, but preserve normal B cells
#ACR22 @RheumNow https://t.co/5ZLocrwqKY
David Liew drdavidliew ( View Tweet)
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GWAS analysis of 2.5m people (120k with gout) showing identifies 1486 candidate causal genes for gout. Looking at urate handling as well as disease propagation (eg. IL1/6). Widespread GWAS allowing us to investigate these diseases differently.
@RheumNow #ACR22 #Plenary
Julian Segan JulianSegan ( View Tweet)
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#ACR22 Highlights. ILD in CTDs #rituximab = #cyclophoshamide at 6 mo for CTD ILD & ritux better on skin score in #scleroderma RECITAL RCT abst0003 but #pirfenidone added to #MMF not better than MMF alone in SLSIII RCT—ILD w #SSc abst#520 vs in SENCIS #nintedanib is + @RheumNow
Janet Pope Janetbirdope ( View Tweet)
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Great moderating PMR talk w/@SattuiSEMD this AM; phenomenal slides @drceowen re:imaging in PMR
Big ?s:
-Who needs this? All/some/many
-Which modality? Nice summary slide
-How to treat "subclinical" GCA (risk of overtreatment imo)
Ideas for next year?
#ACR22 @rheumnow #ACRBest https://t.co/akvsud3YVO
Mike Putman EBRheum ( View Tweet)
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Preterm delivery and HTN disorders in #vasculitis
Abstract #0953 #ACR22 @RheumNow @StanfordRheum
🤰87 deliveries from 1991-2012
🤰Higher risk for preterm delivery (PTD) (RR 4), PPROM (RR 4), HTN dx of preg. (RR 3)
🤰Of spon. PTD, 17% born between 20-31 weeks
Catherine Sims, MD DrCassySims ( View Tweet)
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Can Neural Networks Answer Important Diagnostic Dilemmas in Rheumatology? #ACR22
https://t.co/TThsEQ7RDH https://t.co/ZHNlH3J0de
Links:
Dr. John Cush RheumNow ( View Tweet)
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Ab1676 #ACR22 SAPHYR: Sarilumab in Refractory PMR
52wk SAR 200 mg q2w + 14w taper GC v PBO+GC taper
Primary endpt: sustain response at 52w
Early term 2/2 COVID, 117 pt
SAR remission 28% vs PBO 10%, p=0.02
Data consistent when removes CRP data
PBO: more GCs 2/2 PMR flare
@Rheumnow https://t.co/kHq3juULX1
Eric Dein ericdeinmd ( View Tweet)
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How much does diet and exercise help in knee osteoarthritis?
Pragmatic RCT (WE-CAN), n=823
a diet & exercise intervention program led to:
- 10kg weight loss
- some significant pain improvements
We need to fund diet & exercise programs for OA patients!
ABST1675 #ACR22 @RheumNow https://t.co/Ctm8ZoRF3o
David Liew drdavidliew ( View Tweet)
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Update on ACR Guideline on Prevention and Treatment of GIOP.
Sequential Rx when initial OP Rx and GC discontinued
https://t.co/TWdI728pCp
Mary Beth Humphrey #ACR22 @RheumNow https://t.co/i320si4RJp
Links:
Dr. Antoni Chan synovialjoints ( View Tweet)
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Sarilumab (IL-6R inhibitor) in phase 3 trial for relapsing PMR (SAPHYR trial).
Key inclusion: Disease flare while taking >7.5mg prednisolone
Sustained remission: resolution of symptoms, normalisation of CRP, adherence to prednisolone taper
@RheumNow #ACR22 #Plenary
Julian Segan JulianSegan ( View Tweet)
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Spiera et al. Sarilumab in refractory PMR (SAPHYR) - Phase 3 RCT. Significant effect of IL-6i. @RheumNow #ACR22 Abstr#1676 https://t.co/2MS441B8gU https://t.co/jBd7YJKrTs
Richard Conway RichardPAConway ( View Tweet)
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#ACR highlights - #pegloticase in #gout - less reactions and more benefit w #MTX MIRROR RCT. Better than no MTX. Will change my practice - if I can access to a #peguricase, I will Rx w concomitant MTX Abst#0001 #ACR22 @RheumNow
Janet Pope Janetbirdope ( View Tweet)
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Updated ACR Guidelines on Prevention and Rx of GIOP
Rx recommendations when new fractures occur after 12 months of initial OP Rx
https://t.co/TWdI728pCp
Mary Beth Humphrey #ACR22 @RheumNow https://t.co/wHANvymd5R
Links:
Dr. Antoni Chan synovialjoints ( View Tweet)
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Updated ACR Guidelines on Prevention and Rx of GIOP
OP Rx in special populations
https://t.co/TWdI728XrX
Mary Beth Humphrey #ACR22 @RheumNow https://t.co/0h72a4jXmG
Links:
Dr. Antoni Chan synovialjoints ( View Tweet)