All News
Potential new treatment for Sjogren's
Is there finally something new on the horizon in Sjogren’s syndrome?
Read Article
#ACR22 Plenary II Abstr#1114 Access to therapy/Cost need to be improved since high copays (=> 10USD per month) affects adherence to treatment (HCQ, AZA, MMF but not MTX) in #lupus @RheumNow https://t.co/WnwIhpqDxL
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Ab1117 #ACR22 Deucravacitinib: TYK2 inhibitor in active SLE?
363 pt P2, double-blind PBO-controlled 48 wk study
DEUC 3 mg BID, 6 BID, 12 QB vs PBO:
At 32wk: DEUC 3BID & 6BID > PBO, sustained across all groups at 48wk.
AEs: similar bw PBO and DEUC. No VTE
@RheumNow #ACRBest https://t.co/uamJe05odq
Eric Dein ericdeinmd ( View Tweet)
Scleredema has an indolent course
Affected skin is doughy
Has 3 clinical subgrps:
💠classic adultorum - self-limited, +visceral involvement
💠blood dyscrasia
💠diabetes - visceral involvement is rare
#ACR22 @Rheumnow @rheumarhyme https://t.co/ZlQmCc1WYa
sheila RHEUMarampa ( View Tweet)
Interstitial inflammation in the entire cortical parenchyma in areas w/ and w/o fibrosis identifies at risk SLE pts for CKD progression. Abs 0634 #ACR22 @RheumNow https://t.co/3iBYHPyYXL https://t.co/iSwblT2Amm
Dr. Rachel Tate uptoTate ( View Tweet)
Analysis from Abs 0954 shows that mainly fatigue and back pain have an impact on the mean BASDAI during pregnancy. #ACR22 @RheumNow https://t.co/l5VGKqF2ar https://t.co/fpkl8VRRJP
Dr. Rachel Tate uptoTate ( View Tweet)
QD205 - RA Activity During Pregnancy (abstract #0955) #ACR22
28 yoF with active RA during Pregnancy - What are your treatment options?
https://t.co/jj99qjugFG https://t.co/vioX8xZw0D
Links:
Dr. John Cush RheumNow ( View Tweet)
Dr PMease et al looked into impact of TNFi cycling in their #axSpA cohort:
💠After 6mos on 2nd TNFi, only 15% had ASDAS-LDA, 7% MCID in ASDAS, 8% >50% improvement
💠Cycling to 2nd TNFi limited benefits
⬇️sample size, worth further investigation
#ACR22 @RheumNow ABST#1499 https://t.co/OVJxezdipW
sheila RHEUMarampa ( View Tweet)
Sjogren’s is tough to study, isn’t it?
LOUiSSe (remibrutinib proof-of-concept SjS) - benefit with:
- ESSDAI (primary, obj dx activity) ✅
- auto-Ab ✅
- all patient outcomes ❎
Has already exceeded many attempts
Even then, still some limitations
ABST1113 #ACR22 @RheumNow https://t.co/NlBaFVuuPa
David Liew drdavidliew ( View Tweet)
VEXAS Abs 0823 #ACR22: Pulmonary disease is common VEXAS, frequently pulmonary infiltrates. It remains unclear if respiratory manifestations are part of the primary disease or a co-existing condition. What are you seeing in clinical practice? @RheumNow https://t.co/VBVKLIrsqq https://t.co/QhxtCdNi5v
Dr. Rachel Tate uptoTate ( View Tweet)
Ab1113 #ACR22 Remibrutinib (LOU064, BTK inhib) in Sjogren's
Will there be new Rx for Sjo?
T Dorner: 73 pts Ph2 BTK 100mg BID/100 QD/PBO
Better ESSDAI at wk 24 (p=0.003)
Unstim saliv flow: improved vs PBO, not stat signif
Decreased CXCL13 chemokine
PROs not improved
@RheumNow https://t.co/hJp33JPpHt
Eric Dein ericdeinmd ( View Tweet)
FOREMOST results: Early oligoarticular PsA pts experienced high disease burden/decreased QoL. Small joint involvement, although less commonly seen in oligoarticular PsA, was the most frequently observed pattern. Abs 1018 #ACR22 @RheumNow https://t.co/wBldKM9MTq https://t.co/qOVZd8aTyR
Dr. Rachel Tate uptoTate ( View Tweet)
"If I had one test in a difficult case of suspected PMR, it would be PET/CT" - @LCalabreseDO
#ACR22 @RheumNow
(credit: as heard by @drceowen) https://t.co/w88peUd4j1
David Liew drdavidliew ( View Tweet)
Mx aging rheumatic dx pt
🌟5M approach🌟
🧠Mind (mood/cog)
💊 Medication (polypharm)
🏃 Mobility
👉Multicomplexity (biopsychsoc)
💪🏻 Matters (aligning 2 specific goals)
💥Interdisciplinary💥
#GeriRheum #ACR22 @RheumNow @B_Buehring_MD @UnaMakris
Patricia Harkins DrTrishHarkins ( View Tweet)
Read my new article on @RheumNow #ACR22 https://t.co/ByJ1yrrdj6
Links:
TheDaoIndex KDAO2011 ( View Tweet)
DANBIO registry plenary Abs 1112 finds 1 yr retention following a mandatory nationwide infliximab biosimilar-to-biosimilar switch was high. Retention higher in originator-experienced and in pts w/ low disease activity. #ACR22 @RheumNow https://t.co/ZAV2dcVzXl https://t.co/Kti2bZ1pkZ
Dr. Rachel Tate uptoTate ( View Tweet)
#ACR22 Plenary II. Abstr#1113 Promising news in #Sjogren. Phase 2 RCT showed oral BTK-i Remibrutinib improved ESSDAI score vs Placebo (delta -2.8) & salivary flow at Wks 24. ESSPRI unchanged. No major safety concern. Look forward to Phase 3 results soon @RheumNow #ACRBest https://t.co/z0oy9FvheY
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Sjogren's in a Plenary! Remibrutinib (BTKi) in SjS
Improved ESSDAI at wk 24, but NONE on ESSPRI (more patient-centric ie fatigue, dryness, joint pain)
Definitely helps w/lab abnormalities, but worried benefit for outcomes that matter may be limited
#ACR22 @RheumNow abstr#1113 https://t.co/GutY8KndbR
Mike Putman EBRheum ( View Tweet)
Post hoc analysis of 3 PsA/SPA trials: no effect of tobacco 🚬 on TOFA efficacy But numerically higher TEAEs
Contrasting w/ data from real world TNF
Interesting data but small sample size & events N
https://t.co/gv8uvcThMD
Abs#1036 #ACR22 @Rheumnow https://t.co/HCJT0XF1tg
Aurelie Najm AurelieRheumo ( View Tweet)
Interesting Abs 0825: MAS was most often caused 2nd to a benign disease. Most common presentation: fever w/ cytopenias. Ferritin levels more than 7511 and ferritin/ CRP levels more than 204.5 ass'd w/ higher mortality. #ACR22 @RheumNow https://t.co/HEuMedE9Rh https://t.co/6f4bf7x9Hh
Dr. Rachel Tate uptoTate ( View Tweet)