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Repetitive Testing of Anti-dsDNA Antibodies May Predict Flares in SLE
In abstract #0327 presented during the poster session on Saturday, Dr. Ai Li Yeo and colleagues investigated the usefulness of serial anti-dsDNA testing in predicting flares among SLE patients who have persistently positive anti-dsDNA titers.
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What do you do if a person with #rheumatoidarthritis was great on 1st JAKi. It was 1st line advanced Rx @RheumNow #ACR22
Janet Pope Janetbirdope ( View Tweet)
They're #dopplegangers! #IgG4RD and #GPA both can have similar clinical manifestations, storiform fibrosis and elevated IgG4 levels. Distinguishing factors can be: necrosis, granulomatous inflammation, neutrophilic inflammation, and presence of ANCA #ACR22 @rheumnow https://t.co/6bHibsvcV8
TheDaoIndex KDAO2011 ( View Tweet)
DISCOVER-2:
Guselkumab in bionaïve PsA
Work productivity data at 2 yrs
64% employed at BL; 50% work impairment at BL
84% employed at BL continued to work
Amongst unemployed at BL proportion of pts working rose by >=20%
https://t.co/zqmfFvPPMi
Abst #0509 #ACR22 @Rheumnow https://t.co/J9Fhj1qHfV
Aurelie Najm AurelieRheumo ( View Tweet)
Migratory oligoarticular arthritis of AAV favors the lower extremities and may herald a flare. – Dr. J Stone #ACR22 @rheumnow https://t.co/VdBaeNyCR3
TheDaoIndex KDAO2011 ( View Tweet)
Yamaguchi et al. Effect of concurrent RO62 abs in Jo1+ antisynthetase syndrome. Present in 16%. Associated more muscle involvement 85% vs 59% (p=0.011). Maybe more Raynauds 56% vs 38% (p=0.09)
@rheumnow
#ACR22 Abstr#0162 https://t.co/6XH6qNKkn7 https://t.co/1JQCtCWrw0
Richard Conway RichardPAConway ( View Tweet)
"Serum complement levels are the Rosetta Stone for understanding lupus activity in pregnancy." Dr. Stone @RheumNow #ACR22 https://t.co/4FbThAZyvq
Dr. Rachel Tate uptoTate ( View Tweet)
Raynaud's may not be first presenting symptom in SSc with RNA Pol3 antibodies. May be a mimic of early inflammatory arthritis. Implications for steroid use.
@RheumNow #ACR22 #Pearls https://t.co/FO8dtOTn9V
Julian Segan JulianSegan ( View Tweet)
How is BASDAI reflecting dis activity in pregnant women w/ AS?
Back pain and fatigue from 2nd sem onwards & BASDAI in 3rd sem = poor sens & spe.
Morning stiffness = highest classification value. https://t.co/pafKqpmZFq
Abstr #0374 #ACR22 @Rheumnow https://t.co/IJY0hm01GW
Aurelie Najm AurelieRheumo ( View Tweet)
“Not always bilateral symmetrical arthropathy”
Early RA also px
💥Asymmetric Oligoarthritis
OR
💥Migratory oligoarthritis
🔥not to miss in mig. oligoarthritis
👉ANCA - GPA /MPA
🦵LL>UL
✅GC response
#ACR22 @RheumNow #rheumpearls
Patricia Harkins DrTrishHarkins ( View Tweet)
Narain et al. SSA/SSB and RO52 abs in IIM with ILD. No difference with SSA/SSB+ . RO52+ lung function more likely to decline over time. FVC, p = 0.0117; FEV1, p = 0.0045; DLCO p = 0.0027 @rheumnow #ACR22 Abstr#0164 https://t.co/ixHOwPJAT2 https://t.co/sIkolMoVqk
Richard Conway RichardPAConway ( View Tweet)
Eshagh @TerrierBen et al. AAV in SSC patients. It does happen! 30 cases. More common in lcSSc, Scl70+, fibrosing ILD. Mostly MPA with +MPO and renal disease. @rheumnow #ACR22 Abstr#0435 https://t.co/Qa4LpbQxZX https://t.co/22L9zt8DOG
Richard Conway RichardPAConway ( View Tweet)
Fascinating. Folle et al. Using neural networks to distinguish seropositive RA, seronegative RA, and PsA based on MRI. Especially mind-blowing that can separate sero+ and sero- RA @rheumnow #ACR22 Abstr#242 https://t.co/GvVpzcGxxo https://t.co/jowHXIOF2v
Richard Conway RichardPAConway ( View Tweet)
#RheumPearl: "A creatinine 1.0 mg/dL is likely abnormal in a pregnant patient; pregnancy normally increase eGFR, normal Cr should be 0.4-0.7 mg/dL" - Dr. J Stone @rheumnow #ACR22 https://t.co/PcQGnRdMYZ
TheDaoIndex KDAO2011 ( View Tweet)
Review meds in someone with a flare of cutaneous lupus. These common meds can be culprits.
@RheumNow #ACR22 #Pearls https://t.co/IUer9OqA5W
Julian Segan JulianSegan ( View Tweet)
Abs 0381 at #ACR22 Suggests that ASDAS superior to BASDAI in clinical practice based on gender outcomes. Female gender assoc'd w/ less favorable outcomes across the SpA spectrum, except for CRP. What do you use in clinical practice? @RheumNow https://t.co/HzjPq9KbAH https://t.co/9MU93MkxFN
Dr. Rachel Tate uptoTate ( View Tweet)
Song et al. : cit-specific CD4+ T cells activated & expanded in CCP+ at-risk RA, CCP+ RA converters and early RA pts.
Circulating Ag specific CD4+ T cells < RA converters vs. at-risk pts. Could this be due to migration in the joints?
https://t.co/Vp0Rbwv6RB
#0498 #ACR22 @Rheumnow https://t.co/NoN1ocjC70
Aurelie Najm AurelieRheumo ( View Tweet)
45% of unselected idiopathic uveitis found to have underlying SpA. Don't stop thinking at the diagnosis of AAU.
@RheumNow #ACR22 #Pearls https://t.co/w9zXz6gzUX
Julian Segan JulianSegan ( View Tweet)
#RheumPearl: Pattern of uveitis differs in different SpA Dr. J Kolfenbach #ACR22 @rheumnow https://t.co/Au5zfX2Q5Z
TheDaoIndex KDAO2011 ( View Tweet)
In early hip OA, look for underlying FAI (amongst other secondary causes. Surgical intervention however is very controversial.
@RheumNow #ACR22 #Pearls https://t.co/Gg4EtbnGiT
Julian Segan JulianSegan ( View Tweet)