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Understanding Comorbidities in RMD

2026 EULAR Press Release

People with rheumatic and musculoskeletal diseases (RMD) are at risk of a number of comorbidities, from cardiovascular diseases to cognitive impairment and fractures. The 2026 EULAR Congress showcased new data and ideas around various comorbidities and drug safety issues in people with an RMD – highlighting the need for integrated care. Here are five abstracts to consider.

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EULAR conference

Day 1 Report from EULAR 2026

Jack Cush, MD

The first day of EULAR 2026 in London featured the opening ceremonies, a plenary session, posters nd the first round of major oral presentations to an audience of nearly 15,000 attendees. Here are a few of my favorites from the first day.

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The pain that inflammation does not explain in SpA and PsA

Antoni Chan, MD, PhD

Clinicians often come across the scenario of a patient with well-controlled spondyloarthritis where the ASDAS in the low disease activity range, CRP normalised, joints clinically quiet. However, the patient returns to the clinic still reporting significant pain. Their rheumatologist adjusts the biological, waits, returns. The pain persists.

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Beyond the Scale: Do GLP-1RAs Offer More Than Weight Loss in PsA?

Nelly Ziade

Over 70% of patients with PsA struggle with excess weight, amplifying synovio-entheseal inflammation and blunting biologic response. The rapid uptake of GLP-1RAs in rheumatology has raised an urgent mechanistic question: are clinical gains in PsA driven purely by weight reduction, or do these agents carry intrinsic anti-inflammatory properties? EULAR 2026 offered six abstracts that together illuminate, without fully resolving, this question.

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🤰What happens to RA disease activity during pregnancy? 🔴 Most remain stable 🔴 70% with high disease activity at baseline improve 🔴 20% flare again post-partum ✨ACPA+ improve more ✨ Better outcomes after 2016 (after modern treatments) OP0242 #EULAR2025 @rheumnow https://t.co/i3X566DcN6

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Nelly ZIADE 🍀 Nellziade ( View Tweet)
RheumNow’s expanded coverage of the #EULAR2026 Annual Meeting is sponsored by Bristol Myers Squibb and UCB. RheumNow and its faculty independently select all coverage content.

Dr. John Cush RheumNow ( View Tweet)

Roc-SpA study Active axSpA dse + inad response to TNFi ➡️switch or cycled No significant diff in ASDAS40 at wk24 bet IL-17i & 2nd TNFi Switching to IL-17i not superior to cycling to 2nd TNFi after inad. response to 1st TNFi Shared decision is key AbsOP0235 @RheumNow #EULAR2026 https://t.co/3UP37IEgXv

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sheila RHEUMarampa ( View Tweet)
#EULAR2026 OP002 In 20 active #lupus nephritis patients with paired kidney biopsy at baseline & 1 yr, urine proteomics showed histology response correlated with restoration of immune, coagulation and ECM-remodelling pathways. Need to advance this liquid biopsy in clinic @RheumNow https://t.co/KaZSYlA9V1

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Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
What if we let RA patients choose ttmt? BACH RCT choice between Filgo / scTNFi vs. standard randomisation 55% JAKi vs 45% TNFi Higher ttmt satisfaction 46 vs 33 p=0.012 Less ttmt switches 6 vs 15 p=0.026 Less AE reported Better drug survival Shared decision making is key! https://t.co/1YS0y6YUEH

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Aurelie Najm AurelieRheumo ( View Tweet)
#OP0236: a look at the revised 2025 ASAS-SPARTAN classification criteria for axSpA from the global CLASSIC cohort. The updated criteria achieved 79.5% sensitivity & 90.4% specificity, with MRI & radiographic sacroiliitis remaining central to classification. #EULAR2026 @RheumNow https://t.co/rVIqyCmB8K

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Mrinalini Dey DrMiniDey ( View Tweet)
Is there a ‘window Of opportunity’ for Rx #GCA w #IL6i 🤞 Obtain a better response Rx GCA #GC #TCZ #Upadacitinib #MTX Study tries to answer if effects of #tocilizumab early vs >8wks is diff N=471, 19% new GCA Early vs late TCZ no dif ❎No Not RCT POS0624 #EULAR2026 @RheumNow

Janet Pope Janetbirdope ( View Tweet)

#EULAR2026 OP002 More encouraging news in #Sjogren. A Phase II RCT in N=30 patients with ESSDAI=>5 and/or ESSPRI=>5: Anifrolumab (IFN-IR mAb) improved CRESS response vs PBO (80% vs 30%). Impressive effect size for other endpoints too. Need definitive Phase III RCT @RheumNow https://t.co/W3GbA3gKIs

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Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Does ASA protect against JAKi-associated VTE in #RA? Swedish data (n=26,116): No. JAKi VTE risk remained elevated vs TNFi regardless of concomitant ASA or DOAC use. NSAIDs showed a non-significant trend toward protection. @RheumNow #EULAR2026 POS0068

Jiha Lee JihaRheum ( View Tweet)

COMPARE Trial: CAR-T Cell Rx in 6 refractory active CCP+ RA pts (failed 4-7 prior b/tsDMARDs). After lymphodepletion w/ CTX + fludarabine, B cells depleted w/ neutropenia. Significant drops in CCP, RF, and DAS28, but at wk 12 only 50% ACR 20 response. Encouraging data but not https://t.co/txm32NkOKW
Dr. John Cush RheumNow ( View Tweet)
And we are on! A full house for #EULAR2026 Opening ceremony highlighting @eular_org initiatives in the field of research, education and patient empowerment and a call “better care leading to better lives” by president Xenofon Baraliakos @RheumNow https://t.co/zTQUFcjXBI

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Aurelie Najm AurelieRheumo ( View Tweet)
It’s that time of year again! 🎉 Delighted to once again be joining the @RheumNow faculty to bring you the highlights from #EULAR2026 in London! @bella_mehta @JihaRheum @AurelieRheumo @Janetbirdope @Nellziade @RHEUMarampa @synovialjoints @Yuz6Yusof https://t.co/WvhpYJJNUk

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Mrinalini Dey DrMiniDey ( View Tweet)
ACPA and the Transition from Arthralgia to Rheumatoid Arthritis Patients with clinically suspect arthralgia (CSA), a common prequel to rheumatoid arthritis (RA), showed different patterns of symptoms and progression depending on whether they tested positive for https://t.co/pCaYdEg1gZ
Dr. John Cush RheumNow ( View Tweet)
"the further I look back, the further I can see the future" Dennis McGonagle quoting Winston Churchill to describe his approach to understanding What is New in PsA at #EULAR2026 @eular_org @RheumNow https://t.co/ayInzzb9lO

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Aurelie Najm AurelieRheumo ( View Tweet)
#EULAR2026 OP0125 It’s a case of “teamwork makes the dream work!” Instead of an index to capture heterogeneity in #Sjogren activity, the NECESSITY validated using data from 16 RCTs that a new composite tool, STAR has high sensitivity & specificity. Vital for use in RCTs @RheumNow https://t.co/ftx1uBP11A

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Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
📈 Do SIJ lesions progress in #axSpA? DESIR cohort (n=649, 10yrs): Yes, slowly, but bDMARDs reduce erosion progression #OP0102 #EULAR2026 @RheumNow https://t.co/Ap35q9D6B4

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Nelly ZIADE 🍀 Nellziade ( View Tweet)
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