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Pain in the Neck (7.28.2023)
Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. This week COVID persists, mortality from misdiagnosis, and cervical pain is more than a pain in the neck.
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Pain in the Neck
https://t.co/JxNBJvlekM https://t.co/vaPSDK2vHQ
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IL-23 Inhibitor Performance in Psoriatic Disease
A single center real-world observational study shows three commercially available IL-23 inhibitors have high and similar drug survival and effectiveness in difficult-to-treat psoriasis and PsA.
https://t.co/J3HIDBguj1 https://t.co/uqYf0Bdh0n
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2023 ACR/EULAR Criteria for Calcium Pyrophosphate Deposition Disease
The prevalence of radiographic chondrocalcinosis is estimated to be 4% to ≥10% in older adults, but the prevalence of symptomatic CPPD disease is unknown.
https://t.co/yNQkEwRT3W https://t.co/YG7uBpDrPP
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SGLT2 inhibitor (empagliflozin) given in a lupus mouse (MRL/lpr) model showed a renoprotective effect suggesting the value of non-immunosuppressive therapies to improve renal function. Showed less -dsDNA Abs, proteinuria, renal nephritis damage https://t.co/iPhecsJeJX https://t.co/0TIy2hsPC1
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Link Between Vitamin D and Psoriasis Severity
More than 8M people in the US experience psoriasis-a person’s vitamin D levels could play an important role in psoriasis severity, according to one of the largest studies to date.
https://t.co/bHnYn87wQS https://t.co/JsloVaxHd4
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Rheumatoid vasculitis (RV) metanalysis: RV decreased sincefrom 9.1 (1988-2000) to 3.9 (2001-2010) per million. RV risk increased w/ smoking, disease duration, seropositivity, males, HLA-DRB104, HLA-C3. Common: skin (65–88%), CNS(35–63%), cardiac (33%) https://t.co/O3G4CS1pdx https://t.co/I2RVKR20lX
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Dr. John Cush RheumNow ( View Tweet)
Voclosporin in SLE - Long-Term Safety and Efficacy
The AURORA 2 study evaluated the long-term safety and efficacy of VOC upus nephritis (LN) patients and, after 3 years, demonstrated long term safety and efficacy following the one-year AURORA 1 study.
https://t.co/YmKLuhyCVG https://t.co/X2u9iCckt7
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EULAR/ACR Guidance on HLH/MAS
A EULAR/ACR task force has established evidence based, up-to-date guidance, and expert opinion on the evaluation, management and monitoring of patients with HLH and MAS.
https://t.co/ZQQ75pyvAX https://t.co/t6lj5XaAwB
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Dr. John Cush RheumNow ( View Tweet)
SGLT2 Inhibitors Reduce Gout Flares and CV Events
A cohort analysis shows that gout patients initiating sodium–glucose cotransporter-2 inhibitors (SGLT2is) had lower serum urate levels and fewer gouty flares requiring ED visits or hospitalizations.
https://t.co/XCh7ulamwU https://t.co/dbOAtaflmb
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JAMA: cutaneous hallmarks of dermatomyositis. Printable Patient education overview. https://t.co/8U6DHbJybE https://t.co/e45KCd5gBL
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MMWR: Arthritis Among Children and Adolescents
The CDC estimates that nearly 220,000 children and adolescents had arthritis during 2017–2021.
https://t.co/S1dG60jJ1J https://t.co/rKQ64sopl2
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RNase Treatment of Autoimmune Disorders
U1RNP complex, Ro/SSA and La/SSB are major RNA-containing autoantigens associated with autoimmune disorders.
https://t.co/RuXV3uAVz7 https://t.co/rWaKlmPnEe
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Tofactitinib in PsA & RA: Nine Year Safety Data
A real-world, post-marketing surveillance (PMS) of tofacitinib in PsA and RA shows a consistent pattern of safety with no new safety concerns identified.
https://t.co/erBi7JJtCY https://t.co/9tU361FkfU
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Time to live your life. Do the right thing, make a difference, leave an imprint.. https://t.co/LEY7bFcV2S
Dr. John Cush RheumNow ( View Tweet)
Horizon announced its phase II RCT of Daxdilimab (anti-ILT7 mAB targeting dendritic cells) failed to meet its primary endpoint - BICLA response w/ pred ≤7.5 mg/day @wk48 (DAX=PBO). DAX also under study in alopecia areata, DLE, lupus nephritis https://t.co/8zDCWI5vB1 https://t.co/pVIg4ctvC5
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Unrecognized Mental Health Problems in Autoimmune Diseases
More than half of patients with auto-immune conditions experience mental health conditions such as depression or anxiety, yet most are rarely asked in clinic about mental health symptoms.
https://t.co/wxuGmuPh7D https://t.co/jMZkH1SIcS
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Dr. John Cush RheumNow ( View Tweet)
EULAR/ACR Guidance on HLH/MAS
A EULAR/ACR task force has established evidence based, up-to-date guidance, and expert opinion on the evaluation, management and monitoring of patients with HLH and MAS.
https://t.co/rZkxuaCsSf https://t.co/c0kHKmZbyt
Links:
Dr. John Cush RheumNow ( View Tweet)
Rheumatoid vasculitis (RV) metanalysis: RV decreased sincefrom 9.1 (1988-2000) to 3.9 (2001-2010) per million. RV risk increased w/ smoking, disease duration, seropositivity, males, HLA-DRB104, HLA-C3. Common: skin (65–88%), CNS(35–63%), cardiac (33%) https://t.co/VADI7DbKSc https://t.co/UwJQmzpmkZ
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Dr. John Cush RheumNow ( View Tweet)
While COVID rates are near historic lows & far less dangerous, hospitalizations are up 10.3%, ER visits up 7%, pos. tests rose to 6.3% from 5.8% in the last week https://t.co/TFAt4p24au
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Dr. John Cush RheumNow ( View Tweet)
