All News

voices.jpg

USPSTF Recommends Screening for Anxiety and Depression

d Jack Cush, MD

The U.S. Preventive Services Task Force has recommended that general practitioners actively screen and identify anxiety and depression in all adult patients under 65 yrs.

Read Article
PMR2.jpg

Is PMR the Next Indication for Tocilizumab?

d MedPage Today

About half of patients with steroid-dependent polymyalgia rheumatica (PMR) were able to get off steroids altogether when they were started on tocilizumab (Actemra) infusions, which also improved disease control in most cases, a randomized phase III trial showed.

Read Article
antibody (Keep)

Clinical Profiles Seen with NXP-2 Antibodies

d Jack Cush, MD

A recent review of the myositis associated autoantibody NXP-2 profiles its clinical associations with dermatomyositis (DM), calcinosis, severe myositis and, in some reports, with cancer.

Read Article
yoga-1240391.jpg

Yoga Fails to Benefit Knee Osteoarthritis

d Jack Cush, MD

The Annals of Internal Medicine has published a study showing online yoga education and an unsupervised yoga program may improve physical function did not improve knee pain after 12 weeks and 24 weeks.

Read Article

NIH: 27 pts w/ ROSAH (retinal dystrophy, optic N. edema, splenomegaly, anhidrosis, headache) syndrome, due to dominant mutation ALPK1 - an autoinflammatory Dz w fevers, HA, Abnl CNS MRI, deforming arthritis, AA amyloidosis . https://t.co/Pyb3QNrPnB https://t.co/wxtwOGpKFr

Links:

Dr. John Cush RheumNow ( View Tweet)
Is there link between PsA & autoinflammatory Dz? Study of 120 #PsA pts found 31% w/ AID gene variants (AP1S3, PLCG2, NOD2, NLRP12, all monoallelic variants adn 1/2 genes assoc w/ autosomal dominant disorders. https://t.co/KaL7jheDZ6 https://t.co/09CSW2W3tn

Links:

Dr. John Cush RheumNow ( View Tweet)
Cohort Hip & Cohort Knee (CHECK) study of biomarkers (serum hs-CRP, sCOMP, sPINP sOC and urine uCTX-2) in1002 pts w/ hip or knee OA. Shows CRP, uCTX-2 & sPINP (OR 1.11-1.40) were assoc w/ nocturnal & walking pain, but not fatigue https://t.co/EOU6i24KLO https://t.co/VQWfeLR01x

Links:

Dr. John Cush RheumNow ( View Tweet)
Hydroxychloroquine Dosing and SLE Flares JAMA cohort study examining HCQ dosing in patients with SLE suggests that HCQ doses of 5 mg/kg per day or less, was associated with a higher risk of lupus flares, including moderate or severe lupus flares. https://t.co/B5HqxWDqD3 https://t.co/4crIFBV9XP

Links:

Dr. John Cush RheumNow ( View Tweet)
ACR's State-by-State Report Cards for Rheumatic Disease New report examines access, affordability, and activity and lifestyle factors in all 50 states and DC evaluating how easy it is to live with a rheumatic disease in your state. https://t.co/MmzG9oTfnq https://t.co/UhSM22PMf5

Links:

Dr. John Cush RheumNow ( View Tweet)
RHEUMATOLOGISTS - How do you deal with skin Psoriasis (PSO) activity in your Psoriatic Arthritis Pts?

Dr. John Cush RheumNow ( View Tweet)

#ACR22 abstracts: 0220 Do you think social media can enhance your rheuma medical education, research or professional development? @anzypanzywanzy @anjmsantiago @PhRheumaJr @rheum4you @RHEUMarampa @RheumaRambolMD @doktora_ging #ACRambassador 📌https://t.co/SZB4p0WNu8

Links:

Lisa 🐳🐬 rheumarhyme ( View Tweet)

New CDC data on vaccination/boosters during BA.5 wave for deaths, age 50+ https://t.co/HGyjNwUveD Compared w/unvaccinated: —92% reduction of death for 4 shots —No difference in reduction between 3 and 2 shots (~82%) [that's a 12-fold ⬇️risk of death for 4 shots in July 2022] https://t.co/3JDjCLbEyh

Links:

Eric Topol EricTopol ( View Tweet)
IBD Ups Risk of Psoriatic Disease Findings of a new study suggest a causal effect between inflammatory bowel disease (IBD) and psoriasis (PSO) as well as psoriatic arthritis (PsA), but not vice versa. https://t.co/twam1BcG8I https://t.co/8PFObkNn4J

Links:

Dr. John Cush RheumNow ( View Tweet)
STAR-RA study - real world claims data shows tofacitinib doesnt increase malignancy risk. Study of 83,295 pts (10,504 TOFA). Risk of malignancy w/ TOFA not increased (HR 1.01) w/ RWE or RCT-duplicate cohort (HR 1.1; 95% CI 0.85, 1.62) https://t.co/GIIvs2cK3s

Links:

Dr. John Cush RheumNow ( View Tweet)

EMA has approved 86 biosimilar medicines since 2006 and has issued a harmonizing statement for EU countries that biosimilars are interchangeable with their reference medicine or with an equivalent biosimilar. https://t.co/ajsP1ulZTQ

Links:

Dr. John Cush RheumNow ( View Tweet)

RINOMAX Trial studied single dose of 500 mg rituximab IV in myasthenia gravis - 47 MG pts randomized to RTX or PBO, after 4 mos RTX response (71% vs 29%) superior to PBO. Further studies are needed https://t.co/XvAWRH8fUz

Links:

Dr. John Cush RheumNow ( View Tweet)

Deep Vein Thrombosis reviewed in current Annals of Internal Medicine - VTE is the 3rd most common CVD, seen in 5% of population. Half of VTE assoc w/ transient preventable risk factors. Direct oral anticoagulants are effective and safer https://t.co/6utxivuwf6

Links:

Dr. John Cush RheumNow ( View Tweet)

Propensity matched pairs (n=237 872) of perioperative pts - gabapentin users and nonusers shows perioperative gabapentin use had significantly more delirium (RR 1.28), antipsychotic Rx (1.17 ) & pneumonia (1.11) vs nonusers post surgery https://t.co/UAZs7Vqy6O

Links:

Dr. John Cush RheumNow ( View Tweet)

Colchicine vs cimetidine in PFAPA (Periodic fever, aphthous stomatitis, pharyngitis, adenitis) syndrome. 72 pts given COL vs CIM x 3 mos: # of febrile attacks was significantly decreased by both Rx (noninferior to each other) https://t.co/MO7IQ0e8gf

Links:

Dr. John Cush RheumNow ( View Tweet)

Metals & Hyperuricemia (HU) (20 studies, 63,283 participants): Increased HUA risk arsenic (OR 1.7), calcium (OR 1.76), cadmium (OR 1.19), & lead (OR 1.56), BUT lower w/ molybdenum (OR  0.8). No effect w/ Cu, Fe, Mg, Zn, Cd, Co, Al, Hg, Tl https://t.co/xmdBCCBuEk

Links:

Dr. John Cush RheumNow ( View Tweet)

×