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English for the Biologically-Challenged (8.4.2023)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.  This week highlights Veterans, Vegetarians and Antenatal Corticosteroids.

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Vegetarians have a significantly higher hip fracture risk (HR 1.50) than regular meat-eaters, partly (28%)explained by BMI. UK Biobank compared meat-eaters (n=regular 258,765, occasional 137,954), pescatarians (9557), & vegetarians (7638) https://t.co/EyL1PPpfYE https://t.co/n0wNDVWMuP

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Dr. John Cush RheumNow ( View Tweet)
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Link Between Vitamin D and Psoriasis Severity

d EurekAlert!

More than eight million people in the U.S. experience psoriasis, a condition in which skin cells build up and form itchy dry patches. A person’s vitamin D levels could play an important role in psoriasis severity, according to one of the largest studies to date.

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SGLT2 Inhibitors Reduce Gout Flares and CV Events

d Jack Cush, MD

A cohort analysis shows that gout patients initiating sodium–glucose cotransporter-2 inhibitors (SGLT2is) had lower serum urate levels and fewer gouty flares requiring emergency department (ED) visits or hospitalizations.

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MMWR: Arthritis Among Children and Adolescents

d Jack Cush, MD

The CDC estimates that nearly 220,000 children and adolescents had arthritis during 2017–2021.

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Scleroderma – Thick and Thin (6.30.2023)

d Jack Cush, MD

Dr. Jack Cush reviews the news, journal articles and regulatory decisions from the past week from RheumNow.com. This week focuses on parodoxical psoriasis, scleroderma outcomes and subsets, and alopecia areata therapy.

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High BMI Increases Arthritis Risk

d Jack Cush, MD

Obesity carries many risks, now a new study in Arthritis & Rheumatology shows that higher body mass index (BMI) increases the risk for several rheumatic diseases, especially in women for both gout and psoriatic arthropathy. 

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Supervised 12 weeks High-intensity interval training program Improves Vo2 peak in IA patients But does not improve pain or fatigue It is disappointing but it is also a small study w/ n=30 pts in each group. It is unclear if the type of exercise has an impact on outcome https://t.co/Plk7sflrh5
Aurelie Najm AurelieRheumo ( View Tweet)
Late Breaker - Cardiorespiratory fitness increased in patients with IJD after 12 weeks of supervised HIIT and effect maintained at 6 months. No significant differences in pain and fatigue vs control. HIIT is a viable intervention Norden K Abst#LB0007 #EULAR2023 @RheumNow

Dr. Antoni Chan synovialjoints ( View Tweet)

In ERA high BMI is associated with high BMI is assoc with failure to get to Low disease activity. From NORD-STAR RCT. Cdn CATCH cohort in #early #Rheumatoid #arthritis also shows I is associated w less remission and less sustained remission #EULAR2023 @RheumNow POS0324 https://t.co/9EXY8Dyz74
Janet Pope Janetbirdope ( View Tweet)
Very interesting. Overweight fibromyalgia pts had some sustained benefit of their fibro on a very low calorie ketogenic diet (8 weeks ketogenic, 12 weeks carb reintroduce) Pain improvements matched weight loss. Many questions, I want to see more! POS1339 #EULAR2023 @RheumNow https://t.co/3rIPmSVUwj
David Liew drdavidliew ( View Tweet)
I swear it is muscle, Doctor! GLORIA trial substudy Pred 5 mg/day 2 years in RA pts >65yo: Weight gain 1kg vs. PBO, no increase or redistribution of fat mass but augmentation in lean mass 💪 Probably explained by better disease control (although NS in study, small sample size)

Aurelie Najm AurelieRheumo ( View Tweet)

Comorbidities and metabolic burden in PsA: -Occur EARLY -Early PsA pts > multiple comorbidities & > CV morbidity vs. age-matched early RA pts Independent of BMI & obesity Time to address these as part of dis pathogenesis in PsA https://t.co/qOiGHn2eZT OP0066 #EULAR23 @Rheumnow https://t.co/lK7MbeMybO

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Aurelie Najm AurelieRheumo ( View Tweet)
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Allergic Drug-Induced Arthritis (5.19.2023)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.  This week we delve into some odd associations, repeat drug warnings and the consequences of antirheumatic therapies.

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RCT of 122 active plaque Psoriasis pts (38F, 55M) with low vitamin D (~15). Rx w/ either PBO or Vit D (100K IU, followed by 20K IU/wk x 4 mos). Vitamin D supplementation had no effect on psoriasis severity (but pts had mild PSO). https://t.co/JXtEBaop3c https://t.co/ScGtBUIrm0

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Dr. John Cush RheumNow ( View Tweet)
Study of 481 incident RA: - no risk of RA w/ tea, alcohol & sugar-soft drinks - Incr RA risk seen w/ coffee [≥4 vs ≤1cup, HR=1.24;p=0.04] & diet drinks [HR=1.66;never-smokers] - Reduced RA risk w/ mod EtOH (ever-smokers;HR=0.63) & wine (seropos RA) https://t.co/RQFpxXUT11 https://t.co/ew2imYMLnJ

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Dr. John Cush RheumNow ( View Tweet)
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One in Ten is Bad! (5.12.2023)

d Jack Cush, MD

This week on the Podcast Dr. Jack Cush reviews the news and journal articles, including the risks of dying, developing RA or autoimmune disease!

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Study of 481 incident RA: - no risk of RA w/ tea, alcohol & sugar-soft drinks - Incr RA risk seen w/ coffee [≥4 vs ≤1cup, HR=1.24;p=0.04] & diet drinks [HR=1.66;never-smokers] - Reduced RA risk w/ mod EtOH (ever-smokers;HR=0.63) & wine (seropos RA) https://t.co/gPZkTl9rid https://t.co/khYEZYFotl

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Dr. John Cush RheumNow ( View Tweet)
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National Population Insights (4.28.2023)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports and addresses 3 viewer case questions.

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Denosumab Reduces Type II Diabetes Risk

d Jack Cush, MD

The British Medical Journal has publish a matched cohort analysis demonstrating that adults receiving denosumab had a lower risk of incident type 2 diabetes (NIDDM) compared with those taking oral bisphosphonates for osteoporosis.

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