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FDA Approves BA.4 and BA.5 Omicron COVID Booster Vaccines
Today the FDA authorized the updated Omicron subvariant (BA.4 and BA.5) COVID-19 booster shots manufactured by Pfizer and Moderna; with an anticipated ship/start date of early September 2022. The BA.5 subvariant accounts for more than 88% of U.S. infections.
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NICE Guidelines on Gout Diagnosis and Management
NICE (UK) has systematically reviewed current medical evidence and delivered a set of recommendations with consideration of cost effectiveness.
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Risk of TNFi-related psoriasis in 5088 TNFi Rx children w/ IBD, JIA, or CNO. Compared to non-TNFi exposed, kids on TNFi had an increased PSO risk w/ ADA (IRR 2.70; 1.53-4.75), infliximab (2.34) or etanercept (2.21) & not incr w/ DMARD use https://t.co/MyjLfeoChq https://t.co/A3JJUA1AaM
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Dr. John Cush RheumNow ( View Tweet)
Cranial nerves exam (unknown source) #BJHM #Neurotwitter #Medtwitter #MedEd #medstudents https://t.co/NnUx6tGERn
Brown Journal of Hospital Medicine BrownJHM ( View Tweet)
New data at today's CDC/ACIP meeting on vaccine effectiveness vs BA.5 wave hospitalizations, all adults
https://t.co/64b9g7HW1h
Less protection for both 3rd and 4th dose vaccines compared with the prior wave (BA.2, BA.2.12) https://t.co/JTichjw2I3
Eric Topol EricTopol ( View Tweet)
Calling All Rheumatology Fellows! Join the ACR Fellows-in-Training Subcommittee https://t.co/FSyMjVieAD
Dr. John Cush RheumNow ( View Tweet)
Gout: diagnosis and management—summary of NICE guidance https://t.co/zOdPzGtqg7 https://t.co/N7CJ23vLND
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Dr. John Cush RheumNow ( View Tweet)
OPTION-DM study of 140 diabetic neuropathy pts Rx for 16 weeks w/ one agent (& if no response) an add-on agent. At wk 16, all 3 regimens lowered nerve pain score from 6.6 to 3.3 w/ no difference between Elavil+Lyrica, Lyrica+Elavil, o Cymbalta+Lyrica) https://t.co/rijJyq1DYL https://t.co/NwHF6xuF0j
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Dr. John Cush RheumNow ( View Tweet)
Have you registered for RheumNow yet? With registration you'll be able to sign up for our daily email, as well as our topic specific emails.
RheumNow is where rheumatologists come to learn.
https://t.co/NuN8JL37tk https://t.co/urJGorSzxo
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Dr. John Cush RheumNow ( View Tweet)
Prevalent Sleep Problems in Rheumatoid Arthritis
Data from Data FORWARD (The National Databank for Rheumatic Diseases) reveals that nearly two-thirds of rheumatoid arthritis (RA) patients have self-reported sleep problems.
https://t.co/WHv3BBeI8T https://t.co/awSy2VqBIn
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Dr. John Cush RheumNow ( View Tweet)
Disease Activity Scoring in AOSD
AOSD or sJIA can have dramatic symptom severity, making it easy to gauge disease activity and response to therapy, especially at the outset. However, a validated measure of disease activity has not been agreed upon.
https://t.co/oD6uDD6W8m https://t.co/KxNJeJ31h8
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Dr. John Cush RheumNow ( View Tweet)
ANA Increasing? Part of the NHANES survey, ANA (IIF on HEp-2 cells) was performed on 13,519 in 3 periods: 1988-1991, 1999-2004, and 2011-2012. ANA+ was
11% 1988-1991
11.4% 1999-2004
16.1% 2011-2012 (P <0.0001)
Meaning ~22.3, ~26.6, &~41.5 mil had +ANAs https://t.co/vWYJci3uDV https://t.co/SEIbrYRoRJ
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Dr. John Cush RheumNow ( View Tweet)
SURPRISED? Psoriasis pts have a known increased risk of CV disease. But did you know several papers & metanalyses show increased risk of abdominal aortic aneurysm in PSO (HR 1.30), worse w/ dz activity; lost w/ age, female, DM? https://t.co/UssLZsBJle https://t.co/ESGK8fjjJk https://t.co/CBBYZRCjCA
Dr. John Cush RheumNow ( View Tweet)
Anti-PM-Scl connective tissue diseases - By Paul Breillat (Fellow in Internal Medicine, Paris, France) #connective #scleroderma #myositis #PMScl #InternistAcademy https://t.co/P727E4ddzz
Benjamin Terrier TerrierBen ( View Tweet)
✅ Probably one of my most important slides ⬇️
WHY IS MY #TREATMENT NOT WORKING (or not working enough) 😭 This is really a question we're dealing with everyday in #rheumatology when taking care of patients with #autoimmune and other rheumatic diseases 👍 https://t.co/osUPYSvuWf
Laurent ARNAUD Lupusreference ( View Tweet)
This precipitous drop and current level is substantially worse than 21 peer countries
https://t.co/NAEMjhs4j3 https://t.co/QhrZ1Xnwcr
Eric Topol EricTopol ( View Tweet)
In a nutshell, reducing glucocorticoids in #SLE patients is associated with a number of important clinical benefits and may impact risk of other comorbidities such as BP and infection risk. https://t.co/YBoIU6aK8p
Ian N Bruce Lupusdoc ( View Tweet)
Life expectancy for Americans is the lowest it's been since 1996. Read about the decline from @sheridan_kate https://t.co/QwkOmOt2Tp https://t.co/wavGjOv6q5
STAT statnews ( View Tweet)
Statin Myalgias? Lancet metanalysis of 19 PCTs, >80K pts, @ 1yr, Statin caused a 7% increase in muscle pain or weakness (1·07; 1·04–1·10); thus 1 in 15 had myalgia due to statin (1/10 w/ high dose). After year 1, no signif excess in statin related myalgia https://t.co/6cRJQMymzM https://t.co/RTH56J4FD1
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Dr. John Cush RheumNow ( View Tweet)
After historic drop in 2020 (COVID), life expectancy in USA dropped again, this time a full year to 76.1 years. The lowest since 1996 and the biggest 2-year decline in a century (dropping >2.5 yrs). To date, there have been 1,044,937 COVID deaths in USA https://t.co/aSgtw6MvGs https://t.co/0UKeyGujKe
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Dr. John Cush RheumNow ( View Tweet)